From Fundamental Biology to Societal Impact

1st Edition - September 22, 2022

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  • Editors: Paulo Oliveira, Joao Malva
  • Paperback ISBN: 9780128237618
  • eBook ISBN: 9780128241318

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Aging: From Fundamental Biology to Societal Impact examines the interconnection of the cellular and molecular basis of aging and societal-based challenges and innovative interventions. Sections take a societal-based angle on aging, describing several flagship initiatives for healthy living and active aging in different regions, cover the biology of aging which includes the hallmarks of aging, explain the pathophysiology of aging, describing different comorbidities associated with aging and possible interventions to decrease the impact of aging, and envision future and innovative measures to tackle aging-related morbidities.Contributions from an interdisciplinary panel of experts cover such topics as the biology of aging to physical activity, nutrition, psychology, pharmacology, health care, social care and urban planning.

Key Features

  • Provides a cross-disciplinary approach to aging at both the biological and societal level
  • Highlights frontline scientific knowledge in the biology of aging and its translation into societal interventions
  • Offers insights on the value of aging research and its future impact from a fundamental and translation point-of-view


Public health and aging researchers, cellular and molecular biologists, gerontologists, health and social care providers. Innovation and health technology developers, researchers involved in health economics

Table of Contents

  • Section 1. The Societal Burden of Aging
    1. Aging at a global level
    2. The financial and economical burden of aging worldwide
    3. Flagship initiatives for healthy living and active aging in Europe
    4. Flagship initiatives for healthy living and active aging in Africa
    5. Flagship initiatives for healthy living and active aging in North America
    6. Flagship initiatives for healthy living and active aging in Asia and Oceania
    7. Flagship initiatives for healthy living and active aging in Central and South America

    Section 2. The Biology of Aging
    8. A metabolic and mitochondrial angle on aging
    9. Intracellular communication and aging
    10. Genomic instability and telomere attrition
    11. Cellular senescence during aging
    12. The epigenetics of aging
    13. Disrupted cellular quality control mechanisms in aging
    14. Deregulated nutrient sensing in aging
    15. Stem cells fitness and aging
    16. Programming of early aging

    Section 3. Aging-related physiology, disease and prevention of aging-related diseases
    17. Adherence to therapy and polymedication
    18. Frailty and cognitive decline
    19. Cardiovascular aging
    20. Aging-related neoplasia
    21. Inflammation
    22. Geroscience: An unifying view on aging as a risk factor
    23. Building healthy aging

    Section 4: The Future and Innovation in Aging
    24. The future of innovation in aging
    25. Machine learning in the context of better healthcare in aging
    26. The knowledge and research in aging for the future
    27. The future of integrated care in aged individuals
    28. Moving from reactive to preventive medicine
    29. Personalized medicine: will this work for decreasing aging-related morbidities
    30. Anti-aging interventions: myths and realities

Product details

  • No. of pages: 820
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 22, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128237618
  • eBook ISBN: 9780128241318

About the Editors

Paulo Oliveira

Paulo J. Oliveira, PhD received his Bachelor of Science in Biochemistry and his PhD in Cellular Biology from the Universidade de Coimbra, Portugal. Dr. Oliveira spent more than three years working at the Medical School of the University of Minnesota, Duluth, USA, where he collaborated with several researchers and contributed to the publication of several peer-reviewed manuscripts. Besides research, Dr. Oliveira is often involved in teaching at the Department of Life Sciences, University of Coimbra, as well as in other Universities in Portugal and elsewhere. He has maintained a consistent primary role in the organization of national and international scientific meetings and is currently the President of the European Society for Clinical Investigation. He has over 200 peer-reviewed publications and is currently one of the most well-known researchers in this area, with collaboration with researchers in Europe, Africa and in the USA. He has also been a reviewer for more than 40 different scientific journals and over 10 different funding agencies, including the European Commission (Research Executive Agency) and the Portuguese Foundation for Science and Technology.

Affiliations and Expertise

Principal Investigator, CNC - Center for Neuroscience and Cell Biology, Portugal; Invited Assistant Professor, University of Coimbra, Portugal; President, European Society for Clinical Investigation

Joao Malva

João O. Malva, PhD received his PhD in Cell Biology at the University of Coimbra 1997. He is a Principal Investigator at the Faculty of Medicine of the University of Coimbra (FMUC). He is the Director of the Project Management Unit and Science Coordinator as well as the Secretary of the Assembly at FMUC. Dr. Malva is also the Vice-Director of the Interdisciplinary Research Institute and the Science Coordinator for the consortium “Ageing@Coimbra” – European Reference Site for Active and Healthy Ageing. He is a past President of the Portuguese Society for Neuroscience (2007-2011). His research activity has been focused on Neuroscience with relevant contributions in areas such as neuroprotection, neuroinflammation and neurogenesis in brain repair. He has significant international visibility, including a nomination as full member to EDAB (European DANA Alliance for the Brain).

Affiliations and Expertise

Research Coordinator, Faculty of Medicine, University of Coimbra, Portugal; Coordinator of Ageing@Coimbra, European Innovation Partnership on Active and Healthy Aging Reference Site

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