Adverse Events and Oncotargeted Kinase Inhibitors - 1st Edition - ISBN: 9780128094006, 9780128094457

Adverse Events and Oncotargeted Kinase Inhibitors

1st Edition

Authors: Giuseppe Tridente
eBook ISBN: 9780128094457
Hardcover ISBN: 9780128094006
Imprint: Academic Press
Published Date: 8th May 2017
Page Count: 736
Tax/VAT will be calculated at check-out Price includes VAT (GST)
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
200.00
140.00
140.00
140.00
140.00
140.00
160.00
160.00
185.00
129.50
129.50
129.50
129.50
129.50
148.00
148.00
160.00
112.00
112.00
112.00
112.00
112.00
128.00
128.00
160.86
112.60
112.60
112.60
112.60
112.60
128.69
128.69
Unavailable
Price includes VAT (GST)
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Description

Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases.

A brief history of each drug’s development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement.

This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events.

Key Features

  • Offers a unique and comprehensive publication on the adverse events associated with a new and fast-growing class of medicines
  • Provides a systematic analysis of adverse events aimed at better prevention through understanding and offering insights for the development of safer drugs
  • Uses practical guidelines to establish a leading reference on this class of drugs for educators, researchers, drug developers, clinicians, safety professionals, and more

Readership

Intended for pharmacologists, clinicians and specialists including oncologists, drug safety control officials and drug developers and producers who are working to find effective molecules with the lowest adverse effects profiles; academics involved in drug safety issues and public health professionals

Table of Contents

Part I: General Aspects

1. Introduction
2. Protein and Lipid Kinases
3. Kinase Inhibitors
4. Adverse Events

Part II: Oncotargeted Kinase Inhibitors

5. Imatinib
6. Gefitinib
7. Erlotinib
8. Sorafenib
9. Sunitinib
10. Dasatinib
11. Lapatinib
12. Nilotinib
13. Pazopanib
14. Vandetanib
15. Vemurafenib
16. Crizotinib
17. Ruxolitinib
18. Axitinib
19. Bosutinib
20. Regorafenib
21. Cabozantinib
22. Ponatinib
23. Dabrafenib
24. Trametinib
25. Adatinib
26. Idelalisib
27. Ibrutinib

Part III: Overview

28. Kinase Inhibitors as Adverse Event Inducers
29. Kinase Inhibitors as Drug Class Events
30. Conclusion and Perspectives

Details

No. of pages:
736
Language:
English
Copyright:
© Academic Press 2017
Published:
Imprint:
Academic Press
eBook ISBN:
9780128094457
Hardcover ISBN:
9780128094006

About the Author

Giuseppe Tridente

Professor Emeritus of Immunology and Pathology

School of Medicine and Surgery

Coordinator of the Teachers’ Committee for the Master in Translational Biomedicine

Universita degli Studi di Verona, Italy

Affiliations and Expertise

MD, Professor Emeritus of Immunology and Pathology, School of Medicine and Surgery, Universita degli Studi di Verona, Italy