Adverse Effects of Engineered Nanomaterials

Adverse Effects of Engineered Nanomaterials

Exposure, Toxicology, and Impact on Human Health

1st Edition - January 25, 2012

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  • Editors: Bengt Fadeel, Antonio Pietroiusti, Anna Shvedova
  • Paperback ISBN: 9780128103333
  • eBook ISBN: 9780123869760

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Adverse Effects of Engineered Nanoparticles: A Disease-Oriented Approach provides a systematic evaluation of representative engineered nanomaterial (ENM) of high volume production and of high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies and the general public need to know about nanosafety.  This book, written by leading international experts in nanotoxicology and nanmoedicine, gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers and patients.  The beneficial applications, both diagnostic and therapeutic, of ENM are also highlighted.  This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, and the clinical and pathological consequences of such exposure in the human population.

Key Features

  • Multi-authored book written by leading US and European experts on nanotoxicology and nanomedicine
  • Discusses the health implications and a clinical translation of experimental data in this area
  • Takes a schematic, non-exhaustive approach to summarize the most important research data in this field
  • Includes a glossary, with a brief explanation of the term and with a reference to where the term or phrase has been used will be included within the book


Those directly involved in the field of nanosafety, namely professionals in toxicology, pharmacology, occupational medicine, clinical medicine and nanomedicine. Workers concerned with safety in the pharmaceutics, cosmetics and public health industries, as well as policy makers developing regulatory frameworks and nanotechnology industries/enterprises

Table of Contents

    1. Interactions with the Human Body - Renato Colognato, Margriet V.D.Z. Park, Peter Wick, Wim H. De Jong
    2. Exposure Assessment - Antonio Bergamaschi, Ivo Iavicoli, Kai Savolainen
    3. Biomonitoring - Enrico Bergamaschi, Andrea Magrini
    4. Critical Evaluation of Toxicity Tests - Maria Dusinska, Elise Rundén-Pran, Sara Correia Carreira, Margaret Saunders
    5. Computational Approaches - Vidana Epa, Dave Winkler, Lang Tran
    6. Regulation and Legislation - Maureen R. Gwinn, Birgit Sokull-Klüttgen

    7. Respiratory System - Ken Donaldson, Craig Poland
    8. Cardiovascular System - Jennifer B. Raftis , Nicholas L. Mills, Rodger Duffin
    9. Neurological System - Sandra Ceccatelli, Giuseppe Bardi
    10. Immune System - Diana Boraschi, Albert Duschl
    11. Skin - Nancy A. Monteiro-Riviere, Francesca Larese Filon
    12. Gastrointestinal Tract - Mark A. Jepson
    13. Reproductive Toxicity - Karin Sørig Hougaard, Luisa Campagnolo
    14. Genotoxicity and Cancer - Shareen H. Doak, Ying Liu, Chunying Chen

    15. Diagnostic Applications - Kai Cheng, Zhen Cheng
    16. Therapeutic Applications of Engineered Nanomaterials- Cyrill Bussy, Christoph Alexiou, Robby A. Petros, Andreas Nyström, Laura Methven, Kostas Kostarelos

Product details

  • No. of pages: 360
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: January 25, 2012
  • Imprint: Academic Press
  • Paperback ISBN: 9780128103333
  • eBook ISBN: 9780123869760

About the Editors

Bengt Fadeel

Bengt Fadeel
BENGT FADEEL is Professor of Medical Inflammation Research at the Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, and Adjunct Professor of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA. He served as Vice Chairman of the Institute of Environmental Medicine from 2009-2013. He received his M.D. and Ph.D. degrees from Karolinska Institutet and was elected as a Fellow of the Academy of Toxicological Sciences in 2012. He is a current or past member or coordinator of several EU-funded projects on nanosafety, including NANOMMUNE, MARINA, NANOREG, SUN, and NANOSOLUTIONS, and member of the EU-funded GRAPHENE Flagship Project, and of the national MISTRA Environmental Nanosafety consortium. Dr. Fadeel is also Chair of the Working Group on Systems Biology in the EU Nanosafety Cluster and a member of the WHO-IPCS Working Group on principles and methods to assess the immunotoxicity of nanomaterials. He is Chair of the Scientific Panel of the National Platform for Nanosafety in Sweden. He is author or co-author of more than 200 original papers and review articles to date. Dr. Fadeel was awarded the national Environmental Medicine Prize by the Cancer and Allergy Foundation in 2011 for his research on the opportunities and risks of the emerging nanotechnologies.

Affiliations and Expertise

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Antonio Pietroiusti

Antonio Pietroiusti
ANTONIO PIETROIUSTI received his habilitation as Associate Professor in Occupational Medicine from the Italian Ministry of Education, University and Research in 2013 and he teaches Occupational Medicine at the Faculty of Medicine and Surgery of the University of Rome Tor Vergata (English course). He is also professor of Occupational Medicine at the University “Nostra Signora del Buon Consiglio” of Tirana, Albania. He is/has been member or coordinator of several national projects funded by the Italian Ministry of Health and by the Italian Ministry of Education, University and Research. He is/has been member of two Seventh Framework Program projects on nanosafety including FP7-MARINA and member of one Seventh Framework Program project on the EU/LAC cooperation. He is Editor of the newsletter of the Toxicology Group of the Royal Chemical Society (UK), and served as co-editor of the special issue on Nanotoxicology published by the journal Toxicology and Applied Pharmacology in 2016. He was awarded by the Italian Society of Occupational Medicine in 2012 for his scientific activity in Occupational Medicine. He is author or co-author of 120 scientific articles.

Affiliations and Expertise

Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy

Anna Shvedova

Anna Shvedova
ANNA A. SHVEDOVA is Lead Research Physiologist at National Institute for Occupational Safety and Health (NIOSH) at the Center for Disease Control and Prevention (CDC) and Adjunct Professor of the Department of Physiology and Pharmacology, School of Medicine and Adjunct Professor of the Department of Pharmaceutical Sciences, School of Pharmacy of West Virginia University, WV. Dr. Shvedova received her Ph.D. and D.Sc. degrees from Moscow University, Russia and is currently Principal Investigator of a number of NORA/National Occupational Research Agenda and NTRC/Nanotechnology Research Center projects at the Exposure Assessment Branch/NIOSH/CDC. Dr. Shvedova was founder and first President of the Dermal Toxicology Specialty Section of the Society of Toxicology (SOT). She is member of advisory board committees for US Army, Air Force and NASA projects and served as workpackage leader in the FP7-NANOMMUNE project (2008-2011), and she is a partner of the FP7-NANOSOLUTIONS project (2011-2017) and member of the ethical board review of the Graphene Flagship Project of the European Commission (2016-2020). Dr. Shvedova has been honored with the SOT Public Communication Award in 2001; Alice Hamilton NIOSH Award for paper of the year in Occupational Safety and Health in 2006, 2009; Bullard-Sherwood Award: Research for Practice in 2011, and Women in Toxicology SOT Award in 2007. Dr. Shvedova is board member of the working group on Skin Notation at NIOSH/CDC, Associate Editor of Toxicology & Applied Pharmacology, and Editorial Board Member of Regulatory Toxicology & Pharmacology. Dr. Shvedova is author or co-author of more than 160 scientific articles and book chapters.

Affiliations and Expertise

Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA

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