Adverse Effects of Engineered Nanoparticles: A Disease-Oriented Approach provides a systematic evaluation of representative engineered nanomaterial (ENM) of high volume production and of high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies and the general public need to know about nanosafety.  This book, written by leading international experts in nanotoxicology and nanmoedicine, gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers and patients.  The beneficial applications, both diagnostic and therapeutic, of ENM are also highlighted.  This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, and the clinical and pathological consequences of such exposure in the human population.

Key Features

  • Multi-authored book written by leading US and European experts on nanotoxicology and nanomedicine
  • Discusses the health implications and a clinical translation of experimental data in this area
  • Takes a schematic, non-exhaustive approach to summarize the most important research data in this field
  • Includes a glossary, with a brief explanation of the term and with a reference to where the term or phrase has been used will be included within the book


This book is intended for those directly involved in the field of nanosafety, namely professionals in toxicology, pharmacology, occupational medicine, clinical medicine and nanomedicine.

Secondary markets may include workers concerned with safety in the pharmaceutics, cosmetics and public health industries, as well as policy makers developing regulatory frameworks and nanotechnology industries/enterprises.

Table of Contents

Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health
Edited by Bengt Fadeel, Antonio Pietroiusti & Anna A. Shvedova

About the Editors
List of Contributors
Preface - Bengt Fadeel, Antonio Pietroiusti, Anna A. Shvedova


  1. Interactions with the Human Body - Renato Colognato, Margriet V.D.Z. Park, Peter Wick, Wim H. De Jong
  2. Exposure Assessment - Antonio Bergamaschi, Ivo Iavicoli, Kai Savolainen
  3. Biomonitoring - Enrico Bergamaschi, Andrea Magrini
  4. Critical Evaluation of Toxicity Tests - Maria Dusinska, Elise Rundén-Pran, Sara Correia Carreira, Margaret Saunders
  5. Computational Approaches - Vidana Epa, Dave Winkler, Lang Tran
  6. Regulation and Legislation - Maureen R. Gwinn, Birgit Sokull-Klüttgen,

  8. Respiratory System - Ken Donaldson, Craig Poland
  9. Cardiovascular System - Jennifer B. Raftis , Nicholas L. Mills, Rodger Duffin
  10. Neurological System - Sandra Ceccatelli, Giuseppe Bardi
  11. Immune System - Diana Boraschi, Albert Duschl
  12. Skin - Nancy A. Monteiro-Riviere, Francesca Larese Filon
  13. Gastrointestinal Tract - Mark A. Jepson
  14. Reproductive Toxicity - Karin Sørig Hougaard, Luisa Campagnolo
  15. Genotoxicity and Cancer - Shareen H. Doak, Ying Liu, Chunying Chen


No. of pages:
© 2012
Academic Press
Print ISBN:
Electronic ISBN:

About the authors

Bengt Fadeel

Affiliations and Expertise

Karolinska Institutet, Stockholm, Sweden

Antonio Pietroiusti

Affiliations and Expertise

Tor Vergata University, Rome, Italy

Anna Shvedova

Affiliations and Expertise

NIOSH, Morgantown, WV, USA


"This book is clearly presented with chapters by well-renowned contribution authors.  There are clear images throughout which have been used in particular effect to simplify and summarise models being discussed…Overall this is a useful book which will be of particular interest to students or researchers new to the field of nanotoxicology."--BTS Winter 2012, Issue 41 page 33