Advances in Virus Research - 1st Edition - ISBN: 9780123859877, 9780123859884

Advances in Virus Research, Volume 80

1st Edition

Editors: Karl Maramorosch Aaron Shatkin Frederick Murphy
eBook ISBN: 9780123859884
Hardcover ISBN: 9780123859877
Imprint: Academic Press
Published Date: 22nd July 2011
Page Count: 144
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Table of Contents

  • Mechanistic Intersections Between Picornavirus Translation and RNA Replication
    • I. Background
    • II. IRES-Dependent Translation and IRES-Transacting Factors
    • III. Viral Modification of Canonical and Noncanonical Translation Factors
    • IV. Important Aspects of RNA Replication
    • V. Important RNA Elements in RNA Replication
    • VI. Viral and Cellular Proteins Involved in RNA Replication
    • VII. Alteration of Host Cell Environment and Implications for Replication
    • VIII. The Switch from Viral Translation to Viral RNA Replication
    • Acknowledgments
  • Mycoviruses, RNA Silencing, and Viral RNA Recombination
    • I. Introduction
    • II. Overcoming Technical Challenges to Mycovirus Research
    • III. Antiviral Defense Mechanisms in Fungi
    • IV. Regulation of the Fungal Antiviral RNA Silencing Response
    • V. RNA Silencing Contributes to Mycovirus RNA Recombination
    • VI. Concluding Remarks
  • Viruses and Metabolism
    • I. The Warburg Effect and Cancer Cells
    • II. Human Cytomegalovirus
    • III. Glucose, Pyruvate, and Glutamine Metabolism in HCMV-Infected Cells
    • IV. How does HCMV Accomplish These Alterations in Glucose and Glutamine Metabolism so that Glucose can be Used for Fatty Acid Synthesis?
    • V. Conclusions and Discussion
  • Regulatory Roles of Protein Kinases in Cytomegalovirus Replication
    • I. Introduction
    • II. The Nature of Herpesviral Protein Kinases
    • III. CrossTalk Between Herpesviral and Cellular Protein Kinases
    • IV. Conclusions
    • V. Outlook for antiviral research
    • Acknowledgments
  • HIV Immune Evasion
    • I. Introduction to HIV-1 Pathogenesis
    • II. HIV-1 Nef
    • III. Candidate Host Factors that Partner with Nef
    • IV. Downmodulation of MHC-I: Endocytic Mechanism
    • V. Downmodulation of MHC-I: Evidence for Targeting of Newly Synthesized Protein in the Secretory Pathway
    • VI. Summary
    • Acknowledgments


Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.

The impact factor for 2009 is 5.522 placing it 2nd in the highly competitive category of virology.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Virologists, microbiologists and infectious diseases specialists


No. of pages:
© Academic Press 2011
Academic Press
eBook ISBN:
Hardcover ISBN:


"A mandatory purchase for all types of comprehensive libraries, both public and university, as well as for those interested in or doing research in the field of virology." --MILITARY MEDICINE

"This well known to virologists. It is a valuable aid in maintaining an overview of various facets of the rapidly expanding fields of virology...Timely, informative, and useful to the student, teacher, and research scientist." --AMERICAN SCIENTIST

Ratings and Reviews

About the Editors

Karl Maramorosch Editor

Professor Karl Maramorosch works at Rutgers University, New Brunswick, NJ, USA.

Affiliations and Expertise

Rutgers University, New Brunswick, NJ, USA

Aaron Shatkin Editor

Affiliations and Expertise

Center for Advanced Biotechnology and Medicine, Piscataway, NJ, USA

Frederick Murphy

Frederick Murphy Editor

Frederick A. Murphy, DVM, PhD, is professor, Department of Pathology, University of Texas Medical Branch (UTMB), Galveston. He holds a BS and DVM from Cornell University and a PhD from the University of California, Davis (UC Davis). Formerly he was dean and distinguished professor, School of Veterinary Medicine, and distinguished professor, School of Medicine, UC Davis. Before that he served as director of the National Center for Infectious Diseases, and director of the Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta. He is a member of the Institute of Medicine of the U.S. National Academy of Sciences and is a member of the German National Academy of Sciences and the Belgian Royal Academy of Medicine. He holds an honorary Doctor of Medicine and Surgery from the University of Turku, Finland; an honorary Doctor of Science from the University of Guelph, Canada; an honorary Doctor of Veterinary Medicine from the University of London, United Kingdom; an honorary Doctor of Science from University College Dublin, Ireland; the Presidential Rank Award of the U.S. Government; the PennVet World Leadership Award from the University of Pennsylvania, and the Distinguished Microbiologist Award from the American College of Veterinary Microbiologists. At UTMB, he is a member of the Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, Galveston National Laboratory, and McLaughlin Endowment for Infection and Immunity. His professional interests include the pathology and epidemiology of highly pathogenic viruses/viral diseases: rabies and the rabies-like viruses, arboviruses, hemorrhagic fever viruses, and other neurotropic viruses. He has been a leader in advancing the concepts of “new and emerging infectious diseases” and “new and emerging zoonoses” and “the threat posed by bioterrorism.” Most recently, he has been working on Internet resources on the history of virology: “The Foundations of Virology” at

Affiliations and Expertise

University of Texas Medical Branch, Galveston, TX, USA