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Advances in Virus Research - 1st Edition - ISBN: 9780128118016, 9780128118023

Advances in Virus Research, Volume 97

1st Edition

Serial Editors: Margaret Kielian Thomas Mettenleiter Marilyn Roossinck
Hardcover ISBN: 9780128118016
eBook ISBN: 9780128118023
Imprint: Academic Press
Published Date: 2nd January 2017
Page Count: 258
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Table of Contents

  • Chapter One: Biomedical and Catalytic Opportunities of Virus-Like Particles in Nanotechnology
    • Abstract
    • 1 What Is a Virus-Like Particle?
    • 2 The Essentials of Protein VLP Structure
    • 3 VLPs as Materials
    • 4 VLPs as Templates for Constrained Material Synthesis
    • 5 VLPs for Biomedical Delivery and Imaging
    • 6 VLPs as Metabolic Compartments
    • 7 VLPs as Stimulants of Immunity
    • 8 Outlook
    • Acknowledgments
  • Chapter Two: A Renaissance in Nepovirus Research Provides New Insights Into Their Molecular Interface With Hosts and Vectors
    • Abstract
    • 1 Introduction
    • 2 Taxonomy and Genome Structure
    • 3 Population Structure, Genetic Diversity, and Evolution
    • 4 Genome Expression by Cap-Independent Translation and Polyprotein Processing
    • 5 Replication Proteins and Assembly of Replication Complexes
    • 6 Virion Structure and Encapsidation
    • 7 Viral and Plant Factors Implicated in Cell-to-Cell Movement
    • 8 Host Defense and Virus Counter-Defense Responses
    • 9 Viral Symptom Determinants
    • 10 Transmission
    • 11 Disease Management
    • 12 Conclusions and Future Prospects
    • Acknowledgments
  • Chapter Three: Have NEC Coat, Will Travel: Structural Basis of Membrane Budding During Nuclear Egress in Herpesviruses
    • Abstract
    • 1 Introduction
    • 2 The Role of NEC in Membrane Budding
    • 3 NEC Structures
    • 4 The Hexagonal Lattice of the NEC: Structure and Function
    • 5 NEC Lattice Curvature
    • 6 Regulation of NEC Lattice Assembly
    • 7 NEC and Capsid Deenvelopment at the ONM
    • 8 Summary
    • Acknowledgments
  • Chapter Four: Nonsegmented Negative-Sense RNA Viruses—Structural Data Bring New Insights Into Nucleocapsid Assembly
    • Abstract
    • 1 The Nonsegmented Negative-Sense RNA Viruses
    • 2 The RNA Replication Complex
    • 3 The N0–P Complex
    • 4 A Proposed Scenario for NC Handling and Assembly by the RNA Polymerase Complex
    • 5 Conclusions and Future Directions
    • Acknowledgments
  • Chapter Five: Modified Vaccinia Virus Ankara: History, Value in Basic Research, and Current Perspectives for Vaccine Development
    • Abstract
    • 1 Introduction
    • 2 History and Development of MVA
    • 3 MVA as Tool for Research in Poxvirus Biology
    • 4 Recombinant MVA Vaccines Against Infectious Diseases
    • 5 MVA as Third-Generation Vaccine Against Smallpox
    • 6 Conclusions
  • Index


Advances in Virus Research volume 97, the latest in the series first published in 1953, covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology.

Key Features

  • Contains contributions from leading authorities
  • Informs and updates on all the latest developments in the field of virology


Virologists, microbiologists and infectious disease specialists


No. of pages:
© Academic Press 2017
2nd January 2017
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Editors

Margaret Kielian

Professor Margaret Kielian works at the Department of Cell Biology, Albert Einstein College of Medicine, New York, USA.

Affiliations and Expertise

Department of Cell Biology, Albert Einstein College of Medicine, NY, USA

Thomas Mettenleiter

Thomas Mettenleiter

Born: March 18, 1957 in Goeppingen, Germany

Nationality: German

1963-1967: Elementary School

1967-1976: High School (Gymnasium)

1976: Diploma (Abitur)

1976-1977: Compulsory Military Service

1977-1982: Study of biology at Tuebingen University, Germany

1982-1985: Ph.D. work at Federal Research Centre for Virus Diseases of Animals,

Tuebingen, Germany

1985: Ph.D. in Genetics

1986-1987: Postdoctoral Fellow at Vanderbilt University, Nashville, TN

Department of Microbiology

1988-today: Federal Research Centre for Virus Diseases of Animals

1990: Habilitation (prerequisite for professorship)

since 1994: Director of the Institute of Molecular Biology at the Federal Research Centre for Virus Diseases of Animals, Insel Riems, Germany

since 1996: President of the Federal Research Centre for Virus Diseases of Animals (renamed in 2004 'Friedrich-Loeffler-Institut')

since 1997: Professor of Virology at University of Greifswald

Scientific Work:

More than 300 peer-reviewed publications in international journals (listed in PubMed) on different aspects of infectious animal diseases.

Affiliations and Expertise

Institute of Molecular Biology, Friedrich-Loeffler-Institut, Greifswald, Germany

Marilyn Roossinck

Prof. Marilyn J. Roossinck works at the Center for Infectious Disease Dynamics, Pennsylvania State University, Pennsylvania, USA.

Affiliations and Expertise

Center for Infectious Disease Dynamics, Pennsylvania State University, Pennsylvania, USA