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Advances in Virus Research - 1st Edition - ISBN: 9780128048214, 9780128052372

Advances in Virus Research, Volume 94

1st Edition

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Serial Editors: Margaret Kielian Karl Maramorosch Thomas Mettenleiter
Hardcover ISBN: 9780128048214
eBook ISBN: 9780128052372
Imprint: Academic Press
Published Date: 1st March 2016
Page Count: 198
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Table of Contents

Chapter One: Functional Genomic Strategies for Elucidating Human–Virus Interactions: Will CRISPR Knockout RNAi and Haploid Cells?

  • Abstract
  • 1 Introduction
  • 2 Host–Virus Genetic Screens
  • 3 RNAi Genetic Screening Technologies and Approaches
  • 4 Haploid Cell Genetic Screening Technology and Approach
  • 5 CRISPR/Cas9 Genetic Screening Technologies and Approaches
  • 6 Comparison of HRV-HF Screens: Arrayed MORR RNAi Versus Pooled CRISPR/Cas9
  • 7 Future Directions
  • Acknowledgments

Chapter Two: Alphaherpesvirus Latency: A Dynamic State of Transcription and Reactivation

  • Abstract
  • 1 Introduction
  • 2 A Working Definition of Latency
  • 3 Model Systems to Study Alphaherpesvirus Latency
  • 4 Establishment of Latency
  • 5 The Dynamic State of Alphaherpesvirus Latency
  • 6 Conclusions and Unanswered Questions

Chapter Three: Nuclear Egress of Herpesviruses: The Prototypic Vesicular Nucleocytoplasmic Transport

  • Abstract
  • 1 Introduction
  • 2 The Nucleus
  • 3 Herpesvirus Nuclear Egress
  • 4 Nuclear Egress as a Cellular Nuclear Export Mechanism
  • 5 Alternative Herpesvirus Nuclear Escape Pathways
  • 6 Nuclear Egress in Other Virus Families
  • 7 Summary
  • Acknowledgments

Chapter Four: Structure and Associated Biological Functions of Viroids

  • Abstract
  • 1 Introduction
  • 2 Biophysical Properties as Basis for Functional Activity
  • 3 Structure of Pospiviroidae
  • 4 Structure of Avsunviroidae
  • 5 Structural Motifs and Their Biological Function
  • 6 Perspective
  • Acknowledgments



Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology.

Key Features

  • Contain contributions from leading authorities
  • Informs and updates on all the latest developments in the field of virology


Virologists, microbiologists and infectious disease specialists.


No. of pages:
© Academic Press 2016
1st March 2016
Academic Press
Hardcover ISBN:
eBook ISBN:

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About the Serial Editors

Margaret Kielian

Professor Margaret Kielian works at the Department of Cell Biology, Albert Einstein College of Medicine, New York, USA.

Affiliations and Expertise

Department of Cell Biology, Albert Einstein College of Medicine, NY, USA

Karl Maramorosch

Professor Karl Maramorosch works at Rutgers University, New Brunswick, NJ, USA.

Affiliations and Expertise

Rutgers University, New Brunswick, NJ, USA

Thomas Mettenleiter

Thomas Mettenleiter

Born: March 18, 1957 in Goeppingen, Germany

Nationality: German

1963-1967: Elementary School

1967-1976: High School (Gymnasium)

1976: Diploma (Abitur)

1976-1977: Compulsory Military Service

1977-1982: Study of biology at Tuebingen University, Germany

1982-1985: Ph.D. work at Federal Research Centre for Virus Diseases of Animals,

Tuebingen, Germany

1985: Ph.D. in Genetics

1986-1987: Postdoctoral Fellow at Vanderbilt University, Nashville, TN

Department of Microbiology

1988-today: Federal Research Centre for Virus Diseases of Animals

1990: Habilitation (prerequisite for professorship)

since 1994: Director of the Institute of Molecular Biology at the Federal Research Centre for Virus Diseases of Animals, Insel Riems, Germany

since 1996: President of the Federal Research Centre for Virus Diseases of Animals (renamed in 2004 'Friedrich-Loeffler-Institut')

since 1997: Professor of Virology at University of Greifswald

Scientific Work:

More than 300 peer-reviewed publications in international journals (listed in PubMed) on different aspects of infectious animal diseases.

Affiliations and Expertise

Institute of Molecular Biology, Friedrich-Loeffler-Institut, Greifswald, Germany