Advances in the Neurochemistry and Neuropharmacology of Tourette Syndrome - 1st Edition - ISBN: 9780124115460, 9780124115613

Advances in the Neurochemistry and Neuropharmacology of Tourette Syndrome, Volume 112

1st Edition

Serial Volume Editors: Davide Martino Andrea Cavanna
Hardcover ISBN: 9780124115460
eBook ISBN: 9780124115613
Imprint: Academic Press
Published Date: 1st December 2013
Page Count: 572
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Table of Contents

Series Page

Contributors

Preface: The Metamorphoses of Gilles de la Tourette Syndrome

References

Chapter One. An Introduction to the Clinical Phenomenology of Tourette Syndrome

Abstract

1 Basic Nosography of Primary Tic Disorders

2 Phenomenology

References

Chapter Two. Functional Neuroanatomy of Tics

Abstract

1 Introduction

2 Structural Abnormalities

3 Functional Findings

4 Tics—A Matter of Connectivity?

Acknowledgments

References

Chapter Three. Functional Imaging of Dopaminergic Neurotransmission in Tourette Syndrome

Abstract

1 Introduction

2 Imaging of Cerebral Glucose Metabolism and Cerebral Blood Flow

3 Role of Dopaminergic Modulation in TS

4 The Role of Other Neurotransmitter Systems in TS

5 Conclusion

Acknowledgments

References

Chapter Four. Nondopaminergic Neurotransmission in the Pathophysiology of Tourette Syndrome

Abstract

1 Introduction

2 Role of the Monoamines Norepinephrine and Serotonin

3 Role of the Monoamine Histamine

4 Role of Glutamate

5 Role of GABA

6 Role of ACh

7 Role of Endocannabinoid

8 Role of Corticoid

9 Conclusion

References

Chapter Five. Reinforcement Learning and Tourette Syndrome

Abstract

Abbreviations

1 Reinforcement Learning: Concepts, and Paradigms

2 Neural Correlates of Reinforcement Learning

3 Tourette Syndrome and Reinforcement Learning

4 Conclusions and Perspectives

Acknowledgments

References

Chapter Six. Genetic Susceptibility and Neurotransmitters in Tourette Syndrome

Abstract

1 Introduction

2 Neurotransmitter Abnormalities Associated with TS

3 Neurotransmitter-Related Genetic Findings

4 Histamine-Related Genetic Findings

5 Neurotransmitter-Related Gene Expression Studies of Blood

6 Conclusion and Future Studies

References

Chapter Seven. Pharmacological Animal Models of Tic Disorders

Abstract

Abbreviations

1 Introduction

2 Validity Criteria for Developing Animal Models

3 Animal Models of Tic Disorders

4 Concluding Remarks and Future Perspectives

References

Chapter Eight. Animal Models Recapitulating the Multifactorial Origin of Tourette Syndrome

Abstract

1 Tic Disorders and Tourette Syndrome

2 Tourette Syndrome: Etiological Factors

3 Animal Models of TS

4 Future Perspectives

Acknowledgments

References

Chapter Nine. Neuroendocrine Aspects of Tourette Syndrome

Abstract

1 Introduction

2 Sex Steroid Hormones and TS

3 The Stress Response in TS

4 Neurohypophysial Peptides: Possible Players in the Complex Pathophysiology of TS?

5 Conclusions

References

Chapter Ten. Clinical Pharmacology of Dopamine-Modulating Agents in Tourette’s Syndrome

Abstract

1 Introduction

2 DA Receptor Antagonists

3 Systematic Review of Dopamine Receptor Antagonists in the Treatment of TS

4 Tetrabenazine

5 Dopamine Agonists

6 Summary

References

Chapter Eleven. Clinical Pharmacology of Nondopaminergic Drugs in Tourette Syndrome

Abstract

1 Introduction

2 Alpha2 Receptor Agonists

3 GABA Agonists

4 Cannabinoids

5 Botulinum Toxin

6 Tetrabenazine

7 Nicotine

8 Acetylcholinesterase Inhibitors

9 Immunoglobulins, Plasmapheresis, and Antibiotics

10 Summary and Future Research

References

Further-Reading

Chapter Twelve. Antiepileptic Drugs and Tourette Syndrome

Abstract

1 Introduction

2 TS: From Motion to Emotion

3 Pharmacological Treatments for Tics

4 Treatment with AEDs

5 Discussion

Acknowledgments

References

Chapter Thirteen. Clinical Pharmacology of Comorbid Obsessive–Compulsive Disorder in Tourette Syndrome

Abstract

1 Introduction

2 Obsessive–Compulsive Disorder

3 Treatment of Obsessive–Compulsive Disorder

4 Conclusions

References

Chapter Fourteen. Clinical Pharmacology of Comorbid Attention Deficit Hyperactivity Disorder in Tourette Syndrome

Abstract

1 Introduction

2 Diagnosis and Assessment

3 Overview of Therapeutic Interventions

4 Pharmacological Treatment Options

5 Pharmacotherapy Options Can Be Divided into Three Tiers with First-Tier Drugs Considered First-Choice Treatments

6 Adverse Effects

7 Conclusive Remarks

References

Chapter Fifteen. Emerging Treatment Strategies in Tourette Syndrome: What’s in the Pipeline?

Abstract

1 Introduction

2 Potential and Emerging Pharmacological Treatments

3 Potential and Emerging Nonpharmacological Treatments

4 Conclusion

References

Chapter Sixteen. Tics and Other Stereotyped Movements as Side Effects of Pharmacological Treatment

Abstract

1 General Considerations

2 Tics and Stereotyped Movements After Antipsychotic Exposure

3 Secondary Tics After Treatment with Psychostimulants

4 Tics and Stereotyped Movements and Antiepileptic Drugs

References

Index

Contents of Recent Volumes


Description

This volume of International Review of Neurobiology brings together cutting-edge research on advances in the neurochemistry and neuropharmacology of Tourette syndrome. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and includes important topics regards tics, neurotransmitters, pharmacology and emerging treatments.

Key Features

  • This volume of brings together research on tourettes synrdrome. It reviews current knowledge and understanding on the neurochemistry and neuropharmacology of tourettes syndrome

Readership

Neuroscientists, psychologists, neurologists


Details

No. of pages:
572
Language:
English
Copyright:
© Academic Press 2013
Published:
Imprint:
Academic Press
eBook ISBN:
9780124115613
Hardcover ISBN:
9780124115460

About the Serial Volume Editors

Davide Martino Serial Volume Editor

Affiliations and Expertise

South London NHS Trust, UK

Andrea Cavanna Serial Volume Editor

The Barberry National Centre for Mental Health, Birnimingham, UK