Advances in Radiation Biology - 1st Edition - ISBN: 9780120354108, 9781483281889

Advances in Radiation Biology

1st Edition

Volume 10

Editors: John T. Lett
eBook ISBN: 9781483281889
Imprint: Academic Press
Published Date: 28th April 1983
Page Count: 424
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Description

Advances in Radiation Biology, Volume 10, provides an overview of the state of knowledge in the field of radiation biology. The book contains seven chapters and opens with a study on DNA repair phenomena that have been explored through the use of viruses as probes. This is followed by separate chapters on the behavior of the long-lived synthetic elements and their natural analogs in food chains; the physical and clinical basis for the use of ultrasound to induce local hyperthermia in human tumors; and the role of pH changes in the etiology of thermal cell killing and the potential of low pH as an adjuvant to hyperthermia. Subsequent chapters deal with the effects of accelerated heavy charged particles on various normal tissue systems; the effect of ionizing radiations on connective tissue; and solid tumor response to combined radiotherapy and chemotherapy.

Table of Contents


Contributors


Contents of other Volumes


Viral Probes for DNA Repair


I. Introduction


II. Host Cell Reactivation


III. Recombination-Dependent Recovery


IV. Mismatch Repair


V. Inducible Recovery Phenomena


VI. Viral Vectors for Repair Genes


References


Behavior of the Long-Lived Synthetic Elements and Their Natural Analogs in Food Chains


I. Introduction


II. Entry into Ecosystems


III. Chemical Behavior


IV. Behavior in Food Chains


V. Concluding Comments and Perspectives


References


Cancer Therapy by Ultrasound


I. Introduction


II. Early Studies


III. Physical Aspects of Ultrasound Heating


IV. Preclinical Studies with Ultrasound


V. Clinical Systems for Ultrasound Hyperthermia


VI. Clinical Dosimetry and Treatment Planning for Ultrasound


VII. Responses of Human Tumors to Ultrasound Hyperthermia


VIII. Side Effects of Ultrasound


IX. Conclusions


References


pH and Tumor Response to Hyperthermia


I. Introduction


II. Thermal Sensitivity of Tumors: Selective Temperature Range


III. The Concept of Tumor Acidosis


IV. The Problem of pH Measurement in Tissues


V. Low pH as a Factor in Thermal Sensitivity and as a Mediator of Hyperthermic Cell Killing


VI. Potentiation of Hyperthermia by Low pH


VII. pH and Hyperthermia: Modes of Interaction


VIII. Perspective


References


Heavy-Ion Radiobiology: Normal Tissue Studies


I. Introduction


II. Rationale for the Use of Heavy Charged Particles


III. Generation of Reference Heavy-Ion Beams


IV. Reciprocal Dose

Details

No. of pages:
424
Language:
English
Copyright:
© Academic Press 1983
Published:
Imprint:
Academic Press
eBook ISBN:
9781483281889

About the Editor

John T. Lett

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