Advances in Radiation Biology - 1st Edition - ISBN: 9780120354108, 9781483281889

Advances in Radiation Biology

1st Edition

Volume 10

Editors: John T. Lett
eBook ISBN: 9781483281889
Imprint: Academic Press
Published Date: 28th April 1983
Page Count: 424
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Description

Advances in Radiation Biology, Volume 10, provides an overview of the state of knowledge in the field of radiation biology. The book contains seven chapters and opens with a study on DNA repair phenomena that have been explored through the use of viruses as probes. This is followed by separate chapters on the behavior of the long-lived synthetic elements and their natural analogs in food chains; the physical and clinical basis for the use of ultrasound to induce local hyperthermia in human tumors; and the role of pH changes in the etiology of thermal cell killing and the potential of low pH as an adjuvant to hyperthermia. Subsequent chapters deal with the effects of accelerated heavy charged particles on various normal tissue systems; the effect of ionizing radiations on connective tissue; and solid tumor response to combined radiotherapy and chemotherapy.

Table of Contents


Contributors

Contents of other Volumes

Viral Probes for DNA Repair

I. Introduction

II. Host Cell Reactivation

III. Recombination-Dependent Recovery

IV. Mismatch Repair

V. Inducible Recovery Phenomena

VI. Viral Vectors for Repair Genes

References

Behavior of the Long-Lived Synthetic Elements and Their Natural Analogs in Food Chains

I. Introduction

II. Entry into Ecosystems

III. Chemical Behavior

IV. Behavior in Food Chains

V. Concluding Comments and Perspectives

References

Cancer Therapy by Ultrasound

I. Introduction

II. Early Studies

III. Physical Aspects of Ultrasound Heating

IV. Preclinical Studies with Ultrasound

V. Clinical Systems for Ultrasound Hyperthermia

VI. Clinical Dosimetry and Treatment Planning for Ultrasound

VII. Responses of Human Tumors to Ultrasound Hyperthermia

VIII. Side Effects of Ultrasound

IX. Conclusions

References

pH and Tumor Response to Hyperthermia

I. Introduction

II. Thermal Sensitivity of Tumors: Selective Temperature Range

III. The Concept of Tumor Acidosis

IV. The Problem of pH Measurement in Tissues

V. Low pH as a Factor in Thermal Sensitivity and as a Mediator of Hyperthermic Cell Killing

VI. Potentiation of Hyperthermia by Low pH

VII. pH and Hyperthermia: Modes of Interaction

VIII. Perspective

References

Heavy-Ion Radiobiology: Normal Tissue Studies

I. Introduction

II. Rationale for the Use of Heavy Charged Particles

III. Generation of Reference Heavy-Ion Beams

IV. Reciprocal Dose versus Dose per Fraction Analysis of Multifraction Data

V. Effects on Normal Tissue Systems

VI. Conclusions

References

The Effect of Ionizing Radiations on Connective Tissue

I. Biochemistry, Physiology, and Pathology of Connective Tissue

II. Early Effects of Radiation on Vascular and Other Connective Tissue

III. Late Effects of Radiation on Connective Tissue

IV. Relation between Connective Tissue Metabolism and Aging after Irradiation

V. A Look to the Future and the Problems Which Await Solution

References

Single and Combined (Radiation—Cyclophosphamide) Modality Therapy in Experimental Solid Tumors

I. Introduction

II. Radiation

III. Chemotherapy—Cyclophosphamide

IV. Combined Radiotherapy and Chemotherapy

V. The Alternate and Sequential Use of Combined Modality Therapy

VI. Fractionated and Hyperfractionated Radiation Dose Schedules Alone or in Combination with Cyclophosphamide

VII. The Utilization of Experimental Results in Designing Clinical Protocols

VIII. Concluding Remarks

References

Index

Details

No. of pages:
424
Language:
English
Copyright:
© Academic Press 1983
Published:
Imprint:
Academic Press
eBook ISBN:
9781483281889

About the Editor

John T. Lett