Advances in Radiation Biology

Advances in Radiation Biology

Volume 9

1st Edition - July 28, 1981

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  • Editors: John T. Lett, Howard Adler
  • eBook ISBN: 9781483281896

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Advances in Radiation Biology, Volume 9, provides an overview of the state of knowledge in radiation biology. The book contains nine chapters and begins with a study on the ways in which physical and chemical agents might trigger "regulatory dysfunction" and how these agents might interact with each other. This is followed by separate chapters on the mechanisms underlying changes in vascular function after doses of radiation in the therapeutic range and their role in the development of late effects in normal tissues; the future of hypoxic cell sensitizers in the clinical setting; DNA strand break formation by ionizing radiation; and major pathways which result in radiation-induced loss of cellular proliferative capacity. Subsequent chapters deal with the solid-state radiation chemistry of DNA; radiosensitivity of proliferating mammalian cells; the use of microwave/radiofrequency energy cancer treatment; and the decline of basic radiobiology.

Table of Contents

  • Contributors

    Contents of Other Volumes

    The Role of Radiation and Chemicals in the Induction of Mutations and Epigenetic Changes during Carcinogenesis

    I. Introduction

    II. General Conceptual Overview

    III. Mutations and Carcinogenesis

    IV. An Integrative Theory of Carcinogenesis

    V. Summary


    Radiation-Induced Vascular Injury and Its Relation to Late Effects in Normal Tissues

    I. Introduction

    II. Morphological Changes

    III. Functional Changes

    IV. Mechanisms Underlying Changes in Vascular Function

    V. Response of Endothelial Cells

    VI. The Role of Vascular Damage in Late Effects

    VII. Summary


    Evaluation of Nitroheterocyclic Radiosensitizers Using Spheroids

    I. Introduction

    II. Sensitization of Spheroids

    III. Cytotoxicity of Nitroheterocycles

    IV. Applied Therapy

    V. Other Effects of Nitroheterocycles

    VI. Conclusions and Future Directions


    Radiation-Induced Strand Breaks in DNA: Chemical and Enzymatic Analysis of End Groups and Mechanistic Aspects

    I. Introduction

    II. Frequency of DNA Strand Breaks after Ionizing Radiation

    III. Enzymatic End Group Analysis in Irradiated DNA

    IV. Chemical Analysis of Damage to the Sugar Moiety of Irradiated DNA

    V. Mechanism of DNA Strand Break Formation by Ionizing Radiation Caused by Alterations of the Sugar Moiety

    VI. Summary


    Radiation-Induced Events and Their Time Scale in Mammalian Cells

    I. Introduction

    II. Models

    III. Physical and Physicochemical Processes

    IV. Chemical Processes

    V. Biological Processes

    VI. Implications


    Solid-State Radiation Chemistry of DNA: The Bases

    I. Radiation Biology, DNA, and the Solid State

    II. Evaluation of Free-Radical Assignments

    III. Free-Radical Events Induced by Ionizing Radiation

    IV. Notation

    V. Pyrimidines

    VI. Purines

    VII. Base Complexes


    IX. Closing Comments


    Intrinsic Radiosensitivity of Proliferating Mammalian Cells

    I. Introduction

    II. Radiation Target(s)

    III. Factors Determining Intrinsic Cellular Radiosensitivity

    IV. Concluding Remarks


    Factors Governing the Use of Microwave/Radiofrequency Energies in Cancer Therapy

    I. Introduction

    II. Physical and Biophysical Principles

    III. The Physiology of Temperature Regulation

    IV. Rate of Microwave/Radiofrequency Energy Absorption in Living Systems

    V. Electromagnetic Energy Absorbed Dose in Humans

    VI. Specific Thermal Lesions

    VII. Whole-Body Hyperthermia

    VIII. Local Hyperthermia

    IX. Engineering Considerations

    X. Electromagnetic Field Measuring Instruments and Probes (Dosimetry)

    XI. Problems and Perspectives


    That Was the Basic Radiobiology That Was: A Selected Bibliography and Some Comments

    I. Introduction

    II. The Biophysical/Physicochemical Approach

    III. Mathematical Models

    IV. The Molecular-Biological/Biochemical Approach

    V. Basic or Applied Research in Radiobiology

    VI. Bibliographic Data on Radiobiology

    VII. Textbooks

    VIII. Monographs [M]

    IX. Reviews [R]

    X. Summary and Conclusions

    General References [G]


Product details

  • No. of pages: 492
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: July 28, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9781483281896

About the Editors

John T. Lett

Howard Adler

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