Advances in Radiation Biology

Advances in Radiation Biology

Volume 8

1st Edition - December 28, 1979

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  • Editors: John T. Lett, Howard Adler
  • eBook ISBN: 9781483281902

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Advances in Radiation Biology, Volume 8, provides an overview of the state of knowledge in the field of radiation biology. The book contains nine chapters and opens with a study on aspects of oxygen enhancement ratio and relative biological effectiveness that are relevant to neutron therapy. This is followed by separate chapters on the clinical application of negative pi mesons; the clinical features and cellular and biochemical defects in human diseases, with an emphasis on defects in DNA metabolism, particularly DNA repair; recombination in eukaryotes; and the principal mechanisms of DNA damage and repair in higher plants. Subsequent chapters deal with the effect of oxygen on the repair of radiation damage by cells and tissues; the effects of ionizing radiation on mammalian cells; heritable lesions affecting populations of irradiated mammalian cells; and environmental impact of tritium.

Table of Contents

  • Contributors

    Contents of Other Volumes

    Aspects of OER and RBE Relevant to Neutron Therapy

    I. Introduction

    II. Early Studies

    III. The Rationale for Fast Neutron Therapy

    IV. The Oxygen Effect

    V. Repair after X Rays and Neutrons

    VI. Relative Biological Effectiveness (RBE) for Normal Tissues

    VII. Mixtures of Neutrons and X Rays

    VIII. Responses of Tumors

    IX. Clinical Results

    X. Conclusions


    Present Status of the Proposed Use of Negative Pi Mesons in Radiotherapy

    I. Introduction

    II. The Pion Proposal

    III. Single-Cell Survival

    IV. Somatic-Cell Mutagenesis Studies

    V. Multicellular Tumor Spheroid Studies

    VI. Normal versus Tumor Tissue Responses in the Laboratory

    VII. Normal versus Tumor Tissue Responses in the Clinic

    VIII. Summary


    Human Diseases Associated with Defective DNA Repair

    I. Introduction

    II. Xeroderma Pigmentosum

    III. Ataxia Telangiectasia (Louis-Bar Syndrome)

    IV. Fanconis Anemia

    V. The Hutchinson-Gilford Progeria Syndrome

    VI. Bloom's Syndrome

    VII. Cockayne's Syndrome

    VIII. Down's Syndrome (Trisomy 21)

    IX. Retinoblastoma

    X. Chronic Lymphocytic Leukemia

    XI. Miscellaneous Human Diseases with Possible DNA Repair Defects

    XII. Conclusions


    The Induction of Molecular and Genetic Recombination in Eukaryotic Cells

    I. Introduction

    II. Meiotic Recombination in General

    III. Mitotic Recombination

    IV. Mechanisms of Induced Mitotic Recombination

    V. The Relation between Induced Recombination in Lower and Higher Eukaryotes

    VI. Concluding Comments


    DNA Damage and Repair in Higher Plants

    I. Introduction

    II. Some Features of Injury of Plants and Plant DNA by Radiation and Chemical Treatments

    III. Principal Ways of Repair of DNA Damage

    IV. Initial Approaches to the Study of Repair in Higher Plants

    V. Photoreactivation in Higher Plants

    VI. Excision Repair of Damage Induced in Plant DNA with UV-Irradiation

    VII. Repair of Damage Induced in Plant DNA with Ionizing Radiation

    VIII. Repair of Damage Induced in Plant DNA with Chemical Mutagens and Carcinogens

    IX. Inhibition of Repair Processes in Higher Plants

    X. Repair and Mutagenesis

    XI. Concluding Remarks


    The Effect of Oxygen on the Repair of Radiation Damage by Cells and Tissues

    I. Introduction

    II. Important Aspects of the Oxygen Effect

    III. Repair in Vitro

    IV. Repair in Vivo

    V. Repair of Molecular Damage


    Manifestations of Damage from Ionizing Radiation in Mammalian Cells in the Postirradiation Generations

    I. Introduction

    II. Cellular Effects

    III. Subcellular Effects: Chromosome Aberrations

    IV. Effects on the Synthesis of Macromolecules

    V. Relation of the Behavior of Cells in the Postirradiation Generations to Cell Death


    Heritable Lesions Affecting Proliferation of Irradiated Mammalian Cells

    I. Introduction

    II. Early Observations

    III. Basic Techniques in the Study of Heritable Lesions

    IV. Heritably Damaged Cells

    V. Induction of Heritable Lesions by Densely Ionizing Radiations

    VI. Induction of Heritable Lesions by Tritiated Compounds

    VII. The Oxygen Effect

    VIII. Induction of Heritable Lesions by Alkylating Agents and Other Factors

    IX. Observations in Vivo

    X. Heritable Lesions and Survival Determination

    XI. Late Recovery

    XII. Quantification of Heritably Damaged Cells on the Basis of Growth Observations

    XIII. Postirradiation Intrapopulation Disturbances and Recovery

    XIV. Conjectures as to the Nature of Heritable Lesions and the Mechanisms of Late Recovery

    XV. Significance for Radiotherapy

    XVI. Summary and Future Objectives


    Tritium in the Environment

    I. Introduction

    II. Physical Characteristics

    III. Sources of Tritium

    IV. World Tritium Inventory

    V. Metabolism of Tritium: Intake and Distribution

    VI. Isotopic Effects and Transmutation

    VII. Dosimetry of Tritium

    VIII. Population Exposure to Tritium and Related Risks

    IX. Summary


    Subject Index


Product details

  • No. of pages: 480
  • Language: English
  • Copyright: © Academic Press 1979
  • Published: December 28, 1979
  • Imprint: Academic Press
  • eBook ISBN: 9781483281902

About the Editors

John T. Lett

Howard Adler

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