Advances in Radiation Biology

Advances in Radiation Biology

Volume 7

1st Edition - March 28, 1978

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  • Editors: John T. Lett, Howard Adler
  • eBook ISBN: 9781483281919

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Description

Advances in Radiation Biology, Volume 7, provides an overview of the state of knowledge in the field of radiation biology. The book contains six chapters and opens with a study on the exploitation of the unique properties of purified lesion-recognizing enzymes as the basis of assays that monitor the repair of DNA lesions in vivo. This is followed by separate chapters on the effects of radiation on living eukaryotic cells; the ecological effects of ionizing radiation; and the applicability of bacterial models of DNA repair and recovery to UV-irradiated mammalian cells. Subsequent chapters focus on acute radiation effects on the adult nervous system and the repair of DNA modified by cytotoxic, mutagenic, and carcinogenic chemicals.

Table of Contents


  • Contributors

    Preface

    Contents of Other Volumes

    Use of Purified Lesion-Recognizing Enzymes to Monitor DNA Repair in Vivo

    I. Introduction

    II. Enzymatic Repair Mechanisms

    III. Conventional Repair Assays

    IV. Enzymatic Assays

    V. Experimental Applications of Enzymatic Assays

    VI. Compendium of Lesion-Specific Endonucleases

    VII. Concluding Comments and Perspectives

    Note Added in Proof

    References

    The Crucial Role of DNA Double-Strand Breaks in Cellular Radiobiological Effects

    I. Introduction

    II. The Basis of the Molecular Theory

    III. Cell Survival

    IV. Chromosomal Aberrations

    V. Somatic Mutations

    VI. Radiation-Induced Malignancy

    VII. Hereditary Effects

    VIII. Summary and Conclusions

    References

    Evaluating the Effects of Ionizing Radiation on Aquatic Organisms

    I. Introduction

    II. Dosimetry in the Aquatic Environment

    III. Effects of Ionizing Radiation on Aquatic Invertebrates

    IV. Effects of High-Level Radiation Exposure on Adult Fish

    V. Effects of Acute Irradiation on Teleosts

    VI. Effects of Irradiation on Developing Fish Eggs

    VII. Cytological and Genetic Effects of Irradiation on Aquatic Organisms

    VIII. Effects of Radiation on Natural Populations

    XI. Discussion

    References

    Applicability of Bacterial Models of DNA Repair and Recovery to UV-Irradiated Mammalian Cells

    I. Objective of Review

    II. Repair and Recovery in Bacteria

    III. Excision Repair in Mammalian Cells

    IV. DNA Synthesis and Replication

    V. Postreplication Repair

    VI. Summary and Conclusions

    References

    Electrophysiological Studies on Radiation-Induced Changes in the Adult Nervous System

    I. Introduction

    II. Physiological Changes in the Nervous System Induced by Ionizing Radiation

    References

    The Repair of DNA Modified by Cytotoxic, Mutagenic, and Carcinogenic Chemicals

    Part A. Chemical Modifications to DNA and Their Cytotoxic, Mutagenic, and Carcinogenic Consequences

    I. Introduction

    II. Reactions of Chemicals with Nucleic Acids

    III. Biological Effects of Reactions with DNA

    Part B. Repair of Chemically Modified DNA

    I. Excision Repair

    II. Postreplication Repair

    III. Genetic Factors and DNA Repair

    Part C. Conclusions and Perspectives

    List of Abbreviations

    References

    Subject Index

Product details

  • No. of pages: 460
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: March 28, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9781483281919

About the Editors

John T. Lett

Howard Adler

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