Advances in Radiation Biology - 1st Edition - ISBN: 9780120354061, 9781483281926

Advances in Radiation Biology

1st Edition

Volume 6

Editors: John T. Lett Howard Adler
eBook ISBN: 9781483281926
Imprint: Academic Press
Published Date: 28th July 1976
Page Count: 356
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Advances in Radiation Biology, Volume 6, provides an overview of the state of knowledge in the field of radiation biology. The book contains eight chapters and opens with a study on the nature of radiation effects on nucleic acid metabolism in mammalian cells. This is followed by separate chapters on the nature of UV effects on transcriptional functions; interrelationships between ionizing radiation, protein synthesis, and the physiological expressions of radiation damage; and correlation of DNA repair activities and cellular effects in irradiated mammalian cells. Subsequent chapters deal with the interaction of heat and radiation on an in vitro and an in vivo system; the role of hyperthermia for cancer therapy; thermal potentiation of mammalian cell killing; and autologous stem-cell banks for restoring hemopoiesis.

Table of Contents


Contents of Other Volumes

Effects of Ionizing Radiation on Nucleic Acid Synthesis in Mammalian Cells

I. Introduction

II. Effects of Radiation on the DNA Synthetic Period

III. Radiation Effects on DNA Precursor Metabolism and DNA Synthesis

IV. Possible Mechanisms Associated with Radiation-Induced Depression of DNA Synthesis

V. Ionizing Radiation and RNA Metabolism in the Cultured Mammalian Cell


UV Damage at the Transcriptional Level

I. Introduction

II. In Vitro Transcription of UV-Irradiated DNA Templates

III. In Vivo Transcription of UV-Irradiated DNA

IV. RNA Synthesis in UV-Irradiated Bacteria

V. RNA Synthesis in UV-Irradiated Eukaryotic Cells

VI. Quantitative Correlation of UV Effects on the Transcriptional Template Functions of DNA

VII. Nature of Transcription-Terminating UV Lesions

VIII. Investigating Transcriptional Linkage through UV-Induced RNA Chain Termination

IX. Concluding Remarks



Interrelationships between Ionizing Radiation, Protein Synthesis, and the Physiological Expressions of Radiation Damage

I. Introduction

II. Interrelationships between Protein Synthesis and the Physiological Expression of Radiation Damage

III. Inhibition of Protein Synthesis

IV. Conclusions


Role of DNA Repair in Cell Inactivation, Aging, and Transformation: A Selective Review, A Speculative Model

I. Introduction

II. DNA Repair in Irradiated Mammalian Cells

III. Effects of Radiation in Mammalian Cells

IV. A Model for Correlation of DNA Repair Activities and Cellular Effects in Irradiated Mammalian Cells


Response of Cells in Vitro and Tissues in Vivo to Hyperthermia and X-Irradiation

I. Introduction

II. Effect of Hyperthermia Alone in Vitro

III. Effect of Hyperthermia Plus Radiation in Vitro

IV. Effect of Hyperthermia Alone in Vivo

V. Effect of Hyperthermia and Radiation in Vivo

VI. Discussion

VII. Summary


Experimental and Clinical Aspects of Hyperthermia Applied to the Treatment of Cancer with Special Reference to the Role of Ultrasonic and Microwave Heating

I. Introduction

II. Methods of Inducing Hyperthermia

III. Mechanisms of Action

IV. Effects of Hyperthermia Alone

V. Effects of Hyperthermia with Radiation

VI. Effects of Hyperthermia with Chemotherapy

VII. Microwaves in Cancer Therapy

VIII. Ultrasound in Cancer Therapy

IX. General Summary and Conclusions


Thermal Potentiation of Mammalian Cell Killing: Clues for Understanding and Potential for Tumor Therapy

I. Introduction

II. Effect of Heat Alone on Cells

III. Theoretical Framework for Thermal and Radiation Experiments

IV. Thermal Potentiation of Cell Killing

V. DNA, Strand Breaks, Thermal Effects, and Repair

VI. Remarks on Thermal Potentiation in Tumor Systems

VII. Summary

VIII. Conclusion



Autologous Stem-Cell Banks for Restoring Hemopoiesis

I. Introduction

II. Treating the Hemopoietic Syndrome

III. Stem Cells in Blood

IV. Cryopreservation

V. Feasibility

VI. Summary


Subject Index


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© Academic Press 1976
Academic Press
eBook ISBN:

About the Editor

John T. Lett

Howard Adler

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