Advances in Radiation Biology - 1st Edition - ISBN: 9780120354061, 9781483281926

Advances in Radiation Biology

1st Edition

Volume 6

Editors: John T. Lett Howard Adler
eBook ISBN: 9781483281926
Imprint: Academic Press
Published Date: 28th July 1976
Page Count: 356
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Description

Advances in Radiation Biology, Volume 6, provides an overview of the state of knowledge in the field of radiation biology. The book contains eight chapters and opens with a study on the nature of radiation effects on nucleic acid metabolism in mammalian cells. This is followed by separate chapters on the nature of UV effects on transcriptional functions; interrelationships between ionizing radiation, protein synthesis, and the physiological expressions of radiation damage; and correlation of DNA repair activities and cellular effects in irradiated mammalian cells. Subsequent chapters deal with the interaction of heat and radiation on an in vitro and an in vivo system; the role of hyperthermia for cancer therapy; thermal potentiation of mammalian cell killing; and autologous stem-cell banks for restoring hemopoiesis.

Table of Contents


Contributors


Contents of Other Volumes


Effects of Ionizing Radiation on Nucleic Acid Synthesis in Mammalian Cells


I. Introduction


II. Effects of Radiation on the DNA Synthetic Period


III. Radiation Effects on DNA Precursor Metabolism and DNA Synthesis


IV. Possible Mechanisms Associated with Radiation-Induced Depression of DNA Synthesis


V. Ionizing Radiation and RNA Metabolism in the Cultured Mammalian Cell


References


UV Damage at the Transcriptional Level


I. Introduction


II. In Vitro Transcription of UV-Irradiated DNA Templates


III. In Vivo Transcription of UV-Irradiated DNA


IV. RNA Synthesis in UV-Irradiated Bacteria


V. RNA Synthesis in UV-Irradiated Eukaryotic Cells


VI. Quantitative Correlation of UV Effects on the Transcriptional Template Functions of DNA


VII. Nature of Transcription-Terminating UV Lesions


VIII. Investigating Transcriptional Linkage through UV-Induced RNA Chain Termination


IX. Concluding Remarks


Glossary


References


Interrelationships between Ionizing Radiation, Protein Synthesis, and the Physiological Expressions of Radiation Damage


I. Introduction


II. Interrelationships between Protein Synthesis and the Physiological Expression of Radiation Damage


III. Inhibition of Protein Synthesis


IV. Conclusions


References


Role of DNA Repair in Cell Inactivation, Aging, and Transformation: A Selective Review, A Speculative Model


I. Introduction


II. DNA Repair in Irradiated Mammalian Cells


III. Effects of Radiation in Mammalian Cells


IV. A Model for Correlation of DNA Repair Activities and Cellular Effects in Irradiated Mammalian Cells


Refe

Details

No. of pages:
356
Language:
English
Copyright:
© Academic Press 1976
Published:
Imprint:
Academic Press
eBook ISBN:
9781483281926

About the Editor

John T. Lett

Howard Adler

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