Advances in Radiation Biology

Advances in Radiation Biology

Volume 6

1st Edition - July 28, 1976

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  • Editors: John T. Lett, Howard Adler
  • eBook ISBN: 9781483281926

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Advances in Radiation Biology, Volume 6, provides an overview of the state of knowledge in the field of radiation biology. The book contains eight chapters and opens with a study on the nature of radiation effects on nucleic acid metabolism in mammalian cells. This is followed by separate chapters on the nature of UV effects on transcriptional functions; interrelationships between ionizing radiation, protein synthesis, and the physiological expressions of radiation damage; and correlation of DNA repair activities and cellular effects in irradiated mammalian cells. Subsequent chapters deal with the interaction of heat and radiation on an in vitro and an in vivo system; the role of hyperthermia for cancer therapy; thermal potentiation of mammalian cell killing; and autologous stem-cell banks for restoring hemopoiesis.

Table of Contents

  • Contributors

    Contents of Other Volumes

    Effects of Ionizing Radiation on Nucleic Acid Synthesis in Mammalian Cells

    I. Introduction

    II. Effects of Radiation on the DNA Synthetic Period

    III. Radiation Effects on DNA Precursor Metabolism and DNA Synthesis

    IV. Possible Mechanisms Associated with Radiation-Induced Depression of DNA Synthesis

    V. Ionizing Radiation and RNA Metabolism in the Cultured Mammalian Cell


    UV Damage at the Transcriptional Level

    I. Introduction

    II. In Vitro Transcription of UV-Irradiated DNA Templates

    III. In Vivo Transcription of UV-Irradiated DNA

    IV. RNA Synthesis in UV-Irradiated Bacteria

    V. RNA Synthesis in UV-Irradiated Eukaryotic Cells

    VI. Quantitative Correlation of UV Effects on the Transcriptional Template Functions of DNA

    VII. Nature of Transcription-Terminating UV Lesions

    VIII. Investigating Transcriptional Linkage through UV-Induced RNA Chain Termination

    IX. Concluding Remarks



    Interrelationships between Ionizing Radiation, Protein Synthesis, and the Physiological Expressions of Radiation Damage

    I. Introduction

    II. Interrelationships between Protein Synthesis and the Physiological Expression of Radiation Damage

    III. Inhibition of Protein Synthesis

    IV. Conclusions


    Role of DNA Repair in Cell Inactivation, Aging, and Transformation: A Selective Review, A Speculative Model

    I. Introduction

    II. DNA Repair in Irradiated Mammalian Cells

    III. Effects of Radiation in Mammalian Cells

    IV. A Model for Correlation of DNA Repair Activities and Cellular Effects in Irradiated Mammalian Cells


    Response of Cells in Vitro and Tissues in Vivo to Hyperthermia and X-Irradiation

    I. Introduction

    II. Effect of Hyperthermia Alone in Vitro

    III. Effect of Hyperthermia Plus Radiation in Vitro

    IV. Effect of Hyperthermia Alone in Vivo

    V. Effect of Hyperthermia and Radiation in Vivo

    VI. Discussion

    VII. Summary


    Experimental and Clinical Aspects of Hyperthermia Applied to the Treatment of Cancer with Special Reference to the Role of Ultrasonic and Microwave Heating

    I. Introduction

    II. Methods of Inducing Hyperthermia

    III. Mechanisms of Action

    IV. Effects of Hyperthermia Alone

    V. Effects of Hyperthermia with Radiation

    VI. Effects of Hyperthermia with Chemotherapy

    VII. Microwaves in Cancer Therapy

    VIII. Ultrasound in Cancer Therapy

    IX. General Summary and Conclusions


    Thermal Potentiation of Mammalian Cell Killing: Clues for Understanding and Potential for Tumor Therapy

    I. Introduction

    II. Effect of Heat Alone on Cells

    III. Theoretical Framework for Thermal and Radiation Experiments

    IV. Thermal Potentiation of Cell Killing

    V. DNA, Strand Breaks, Thermal Effects, and Repair

    VI. Remarks on Thermal Potentiation in Tumor Systems

    VII. Summary

    VIII. Conclusion



    Autologous Stem-Cell Banks for Restoring Hemopoiesis

    I. Introduction

    II. Treating the Hemopoietic Syndrome

    III. Stem Cells in Blood

    IV. Cryopreservation

    V. Feasibility

    VI. Summary


    Subject Index

Product details

  • No. of pages: 356
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: July 28, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9781483281926

About the Editors

John T. Lett

Howard Adler

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