Description

This eclectic volume features two major topics: applications of mass spectrometry in bioscience; and computational methods for analysis of protein structure and interactions with other macromolecules.

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.

Key Features

  • Describes advances in application of powerful techniques in a wide bioscience area
  • Chapters are written by authorities in their field
  • Targeted to a wide audience of researchers, specialists, and students
  • The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables

Readership

The intended audiences for this volume are researchers and specialists in protein structure and interactions, cancer biology, psychiatry and mass spectrometry. This volume would be also of a great use to students working on projects from the abovementioned areas.

Table of Contents

Contributors
Chapter One: Bioinformatics Tools to Identify and Quantify Proteins Using Mass Spectrometry Data
Abstract

1 Introduction

2 MS Data

3 Protein Identification

4 Protein Quantification

5 Conclusion

Acknowledgments

Chapter Two: Unraveling Oxidation-Induced Modifications in Proteins by Proteomics
Abstract

1 A Very Brief Introduction to Oxidative Stress and Redox Homeostasis

2 Proteins as Targets of Oxidative Modification

3 Redox Proteomics: The Comprehensive Study of Oxidation-Induced Protein Damage

4 The Use of Proteomics for Mapping the Redox Homeostasis Network: Lessons from Cancer Research

5 Perspectives and Conclusions

Chapter Three: Role of Proteomics in Biomarker Discovery: Prognosis and Diagnosis of Neuropsychiatric Disorders
Abstract

1 Summary

2 Commonly Used Methods for Proteome Characterization

3 Proteomics and Biomarker

4 Diagnosis of Neuropsychiatric Disorders

5 Proteomics of Neuropsychiatric Disorders

6 Strength, Weakness, and Future Challenges: Biomarker Discovery

7 Concluding Remarks

Chapter Four: On the Use of Knowledge-Based Potentials for the Evaluation of Models of Protein–Protein, Protein–DNA, and Protein–RNA Interactions
Abstract

1 Introduction

2 Knowledge-Based Potentials

3 Modeling of Protein Interactions Using Templates

4 Modeling Interactions of Proteins Using Docking

5 Prediction of Protein-Binding Regions

6 Characterization of Transcription Factor-Binding Sites

7 Adapting Split-Statistical Potentials for Protein–DNA Interactions

8 Conclusions

Acknowledgments

Chapter Five: Algorithms, Applications, and Challenges of Protein Structure Alignment
Abstract

1 Introduction

2 Structural Alphabet

3 Protein Pairwise Structure Alignment

4 Protein

Details

No. of pages:
488
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780128003732
Print ISBN:
9780128001684

Reviews

This eclectic volume features two major topics: applications of mass spectrometry in bioscience; and computational methods for analysis of protein structure and interactions with other macromolecules.

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.