Advances in Protein Chemistry and Structural Biology

Advances in Protein Chemistry and Structural Biology

1st Edition - August 13, 2011

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  • Editor: Rossen Donev
  • eBook ISBN: 9780123864840

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Description

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Protein Aggregation.

Key Features

  • Covers reviews of methodology and research in all aspects of protein chemistry
  • Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Table of Contents

  • Nucleic acid-mediated protein aggregation and assembly
    I. Introduction
    II. Nucleic Acid-Mediated Aggregation of Amyloid Proteins
    III. Nucleic Acid Sequestration to Pathological Tissues
    IV. Self-Assembly of Protein Nanostructures in the Presence of Nucleic Acids
    V. Summary

    Aggregation, stability, and formulation of human antibody therapeutics
    I. Introduction
    II. Expression of Human Monoclonal Antibodies and Antibody Fragments
    III. Methods for Analyzing Solubility, Aggregation and Stability of Monoclonal Antibodies
    IV. Addressing Aggregation and Increasing Stability of Monoclonal Antibodies

    Lysozyme
    I. Introduction
    II. Amyloid and Amyloidosis
    III. Human Lysozyme
    IV. Aggregation of Hen Lysozyme In Vitro
    V. Recovery and Purification of Lysozyme from Inclusion Bodies
    VI. Inhibition of Lysozyme Aggregation
    VII. Future Perspectives

    Protein aggregation in a membrane environment
    I. Introduction
    II. The Role of Electrostatics in Membrane-Mediated Protein Aggregation
    III. Hydrophobic Effect as Driving Force for Protein Aggregation
    IV. Hydrogen-Bonding as Determinant of Protein Aggregation Propensity
    V. Experimental Techniques Used to Study Protein Aggregation
    VI. Concluding Remarks

    Contactins
    I. Introduction
    II. Genetic Implication of CNTN4, CNTN5, and CNTN6 in Neurodevelopment
    III. Expression of Contactins During Brain Development
    IV. Phenotypes in Contactin Null-Mutants
    V. Structural Architecture of Contactins
    VI. Protein–Protein Interactions Mediated by Contactins
    VII. Final Remarks
    Author Index
    Subject Index

Product details

  • No. of pages: 216
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: August 13, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780123864840

About the Serial Volume Editor

Rossen Donev

Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

Affiliations and Expertise

Head of Research, MicroPharm Limited, UK

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