Advances in Protein Chemistry and Structural Biology - 1st Edition - ISBN: 9780123812643, 9780123812650

Advances in Protein Chemistry and Structural Biology, Volume 80

1st Edition

Serial Editors: Rossen Donev
Hardcover ISBN: 9780123812643
eBook ISBN: 9780123812650
Imprint: Academic Press
Published Date: 7th December 2010
Page Count: 296
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Table of Contents

  1. Proteomics technologies for the global identification and quantification of proteins
  2. Ian A. Brewis and P. Brennan

  3. Targeted metabolomics and mass spectrometry
  4. E. Dudley, M. Yousef, Y. Wang, W.J. Griffiths

  5. Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling
  6. Tatyana Karabencheva and Christo Christov

  7. Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling
  8. Jonathan G. L. Mullins, Seo-Kyung Chung and Mark I. Rees

  9. Positive and Negative Modulation of Nicotinic Receptors
  10. Hugo R. Arias

  11. Sonochemically Born Proteinaceous Micro- and Nanocapsules

Elena D. Vassileva and Neli S. Koseva


Description

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Key Features

  • Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy
  • Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists


Details

No. of pages:
296
Language:
English
Copyright:
© Academic Press 2010
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780123812643
eBook ISBN:
9780123812650

Ratings and Reviews


About the Serial Editors

Rossen Donev

Rossen Donev Serial Editor

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on design of antibody-based oral treatment of pathological conditions of the gastrointestinal tract.

Affiliations and Expertise

Swansea University, UK