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Advances in Planar Lipid Bilayers and Liposomes - 1st Edition - ISBN: 9780124186989, 9780124199590

Advances in Planar Lipid Bilayers and Liposomes, Volume 20

1st Edition

Serial Editors: Aleš Iglič Chandrashekhar Kulkarni
Hardcover ISBN: 9780124186989
eBook ISBN: 9780124199590
Imprint: Academic Press
Published Date: 15th July 2014
Page Count: 238
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Table of Contents

  • Preface
  • Chapter One: Biomimetic Membrane Supported at a Metal Electrode Surface: A Molecular View
    • Abstract
    • 1 Introduction
    • 2 sBLM Preparation Methods
    • 3 Potential Drop Across the Membrane and an Estimate of the Electric Field Acting on the Membrane
    • 4 Effect of the Potential Applied to the Gold Electrode on the Membrane Stability: AFM, NR, and Surface-Enhanced Infrared Absorption Spectroscopy Studies
    • 5 Imaging Aggregation of Antibiotic Peptides in a Lipid Membrane
    • 6 Potential-Controlled Changes in the Orientation and Conformation of Peptides and Peripheral Proteins: IR Studies of Gramicidin and Cholera Toxin B
    • 7 Summary and Conclusions
    • Acknowledgment
  • Chapter Two: Lipid Monolayers at the Air–Water Interface: A Tool for Understanding Electrostatic Interactions and Rheology in Biomembranes
    • Abstract
    • 1 Introduction
    • 2 Experimental Approaches on Monolayers
    • 3 Phase Diagrams: Two-Phase Regions
    • 4 Distribution of the Phases in the Plane of the Monolayer
    • 5 In-Plane Interactions and Consequences on Film Effective Rheology
    • 6 Comparison Between Different Model Membranes
    • 7 Summary
    • Acknowledgments
  • Chapter Three: Langmuir–Blodgett Approach to Investigate Antimicrobial Peptide–Membrane Interactions
    • Abstract
    • 1 Introduction
    • 2 Target Membrane Architecture
    • 3 The Role of Phospholipids
    • 4 Lipid Monolayers
    • 5 Effect of Phospholipid Packing Characteristics and Lipid Phase Transitions on Membrane Stability
    • 6 Visualization of Lipid Films
    • 7 Conclusion
  • Chapter Four: Divalent Metal Cations in DNA–Phospholipid Binding
    • Abstract
    • 1 Introduction
    • 2 DNA–Phospholipid–Divalent Metal Cation Interaction
    • 3 Divalent Metal Cations as a Mediator of DNA–Neutral Phospholipid Bilayer Binding
    • 4 The Structural Variety of DNA–PC–Me2 + Aggregates
    • 5 Conclusion
    • Acknowledgments
  • Chapter Five: Solid-Like Domains in Mixed Lipid Bilayers: Effect of Membrane Lamellarity and Transition Pathway
    • Abstract
    • 1 Introduction
    • 2 Materials and Methods
    • 3 Results and Discussion
    • 4 Summary and Outlook
    • Acknowledgments
  • Chapter Six: Hexagonal Phase Formation in Oriented DPPC–Melittin Samples: A Small-Angle X-ray Diffraction Study
    • Abstract
    • 1 Introduction
    • 2 Materials and Methods
    • 3 Results and Discussion
    • Acknowledgment
  • Chapter Seven: Probing the Self-Assembly of Unilamellar Vesicles Using Time-Resolved SAXS
    • Abstract
    • 1 Introduction
    • 2 Experimental Method
    • 3 SAXS Analysis of Unilamellar Vesicles
    • 4 Summary and Outlook
    • Acknowledgments
  • Chapter Eight: Defects in Planar Cell Polarity of Epithelium: What Can We Learn from Liquid Crystals?
    • Abstract
    • 1 Introduction
    • 2 Liquid Crystals
    • 3 Principles of Pattern Formation in Epithelial Tissues
    • 4 Results
    • 5 Discussion
  • Index


Although the origin and the basic meaning of the terms "planar lipid bilayers" and "liposome" have not changed during the years, the present advances in the scientific, technological, biomedical and consumer product fields are remarkable. Ever since its launch the "Adances in Planar Lipid Bilayers and Liposomes’ (APLBL) has provided a global platform for a community of researchers having very broad scientific interests in theoretical, experimental and simulation studies on lipid and cell membrane micro and nanostructures. Ranging from artificial lipid membranes to cell membranes, controlled release of functional molecules, drug delivery to cancer cells, pharmaceutical formulations to food products, the applications are simply enormous. An assortment of chapters in APLBL represents both an original research as well as comprehensives reviews written by world leading experts and young researchers.

Key Features

  • Gives a survey on recent theoretical as well as experimental results on lipid micro and nanonanostructures
  • In addition, the potential use of the basic knowledge in applications like clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering and food products is presented


The APLBL book series not only serves as a podium for non-specialists working on interdisciplinary fronts but also retains its special significance for experts in the field of chemistry, physics and biology of lipid micro and nanostructures and biological membranes.


No. of pages:
© Academic Press 2014
15th July 2014
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Editors

Aleš Iglič

Aleš Iglič

Aleš Iglič received his B.Sc. and Ph.D. degrees in physics and M.Sc. degree in biophysics from the Department of Physics, and the Ph.D. degree in electrical engineering from the Faculty of Electrical Engineering, all from the University of Ljubljana. He is a Full Professor and the Head of Laboratory of Biophysics of the Faculty of Electrical Engineering at University of Ljubljana. His main research interests are in electrostatics, mechanics and statistical physics of lipid nanostructures and biological membranes. He is devoted to higher education, basic research in biophysics and close contacts to clinical practice. Prof. Iglič was visiting scientist and professor at Åbo Academy University in Turku (Finland), Friedrich Schiller University in Jena (Germany) and Czech Technical University in Prague (Czech Republic). He established collaborations with researchers from different universities across the Europe, USA and India and was supervisor of many M.Sc., Ph.D. and postdoctoral students from Slovenia, Czech Republic, Poland, Iran, Bulgaria, Germany, India and Israel. Since 2009 is the editor of Elsevier book series »Advances in Planar Lipid Bilayers and Liposomes« (APLBL).

Affiliations and Expertise

Faculty of Electrical Engineering, University of Ljubljana, Slovenia

Chandrashekhar Kulkarni

Chandrashekhar Kulkarni

Chandrashekhar V. Kulkarni received his PhD in Chemical Biology from University of London for which he was in receipt of a Marie Curie Early Stage Researcher Fellowship at Imperial College London (2005-2008). Earlier he completed his BSc (1999) and MSc (2001) in Chemistry from Shivaji University Kolhapur, India and started his research career at the National Chemical Laboratory Pune, India. He had a few postdoc stints at University of Graz-Austria, University of Bayreuth-Germany and University of Cambridge-UK during which he worked on a wide range of projects. In March 2013 Dr Kulkarni started ‘Lipid Nanostructures Group’ focussing on highly interdisciplinary and cutting-edge projects. Some of his research interests include complex biomembranes and biomolecule interactions, nanostructured lipid particles as carrier systems, and novel nano-bio-applications of lipid nanostructures. Dr Kulkarni joined the editorial board of APLBL in early 2013 and later as an editor of this book series.

Affiliations and Expertise

University of Central Lancashire, UK