Advances in Planar Lipid Bilayers and Liposomes
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Although the origin and the basic meaning of the terms "planar lipid bilayers" and "liposome" have not changed during the years, the present advances in the scientific, technological, biomedical and consumer product fields are remarkable. Ever since its launch the "Advances in Planar Lipid Bilayers and Liposomes’ (APLBL) has provided a global platform for a community of researchers having very broad scientific interests in theoretical, experimental and simulation studies on lipid and cell membrane micro and nanostructures. Ranging from artificial lipid membranes to cell membranes, controlled release of functional molecules, drug delivery to cancer cells, pharmaceutical formulations to food products, the applications are simply enormous. An assortment of chapters in APLBL represents both an original research as well as comprehensives reviews written by world leading experts and young researchers.
Key Features
- Gives a survey on recent theoretical as well as experimental results on lipid micro and nanonanostructures
- In addition, the potential use of the basic knowledge in applications like clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering and food products is presented
Readership
The APLBL book series not only serves as a podium for non-specialists working on interdisciplinary fronts but also retains its special significance for experts in the field of chemistry, physics and biology of lipid micro and nanostructures and biological membranes
Table of Contents
- Preface
One: Biomimetic Membrane Supported at a Metal Electrode Surface: A Molecular View
Abstract
1 Introduction
2 sBLM Preparation Methods
3 Potential Drop Across the Membrane and an Estimate of the Electric Field Acting on the Membrane
4 Effect of the Potential Applied to the Gold Electrode on the Membrane Stability: AFM, NR, and Surface-Enhanced Infrared Absorption Spectroscopy Studies
5 Imaging Aggregation of Antibiotic Peptides in a Lipid Membrane
6 Potential-Controlled Changes in the Orientation and Conformation of Peptides and Peripheral Proteins: IR Studies of Gramicidin and Cholera Toxin B
7 Summary and Conclusions
Acknowledgment
Two: Lipid Monolayers at the Air–Water Interface: A Tool for Understanding Electrostatic Interactions and Rheology in Biomembranes
Abstract
1 Introduction
2 Experimental Approaches on Monolayers
3 Phase Diagrams: Two-Phase Regions
4 Distribution of the Phases in the Plane of the Monolayer
5 In-Plane Interactions and Consequences on Film Effective Rheology
6 Comparison Between Different Model Membranes
7 Summary
Acknowledgments
Three: Langmuir–Blodgett Approach to Investigate Antimicrobial Peptide–Membrane Interactions
Abstract
1 Introduction
2 Target Membrane Architecture
3 The Role of Phospholipids
4 Lipid Monolayers
5 Effect of Phospholipid Packing Characteristics and Lipid Phase Transitions on Membrane Stability
6 Visualization of Lipid Films
7 Conclusion
Four: Divalent Metal Cations in DNA–Phospholipid Binding
Abstract
1 Introduction
2 DNA–Phospholipid–Divalent Metal Cation Interaction
3 Divalent Metal Cations as a Mediator of DNA–Neutral Phospholipid Bilayer Binding
4 The Structural Variety of DNA–PC–Me2 + Aggregates
5 Conclusion
Acknowledgments
Five: Solid-Like Domains in Mixed Lipid Bilayers: Effect of Membrane Lamellarity and Transition Pathway
Abstract
1 Introduction
2 Materials and Methods
3 Results and Discussion
4 Summary and Outlook
Acknowledgments
Six: Hexagonal Phase Formation in Oriented DPPC–Melittin Samples: A Small-Angle X-ray Diffraction Study
Abstract
1 Introduction
2 Materials and Methods
3 Results and Discussion
Acknowledgment
Seven: Probing the Self-Assembly of Unilamellar Vesicles Using Time-Resolved SAXS
Abstract
1 Introduction
2 Experimental Method
3 SAXS Analysis of Unilamellar Vesicles
4 Summary and Outlook
Acknowledgments
Eight: Defects in Planar Cell Polarity of Epithelium: What Can We Learn from Liquid Crystals?
Abstract
1 Introduction
2 Liquid Crystals
3 Principles of Pattern Formation in Epithelial Tissues
4 Results
5 Discussion
Index
Product details
- No. of pages: 238
- Language: English
- Copyright: © Academic Press 2014
- Published: July 15, 2014
- Imprint: Academic Press
- eBook ISBN: 9780124199590
- Hardcover ISBN: 9780124186989
About the Serial Editors
Ales Iglic
Aleš Iglič received his B.Sc. and Ph.D. degrees in physics and M.Sc. degree in biophysics from the Department of Physics, and the Ph.D. degree in electrical engineering from the Faculty of Electrical Engineering, all from the University of Ljubljana. He is a Full Professor and the Head of Laboratory of Biophysics of the Faculty of Electrical Engineering at University of Ljubljana. His main research interests are in electrostatics, mechanics and statistical physics of lipid nanostructures and biological membranes. He is devoted to higher education, basic research in biophysics and close contacts to clinical practice. Prof. Iglič was visiting scientist and professor at Åbo Academy University in Turku (Finland), Friedrich Schiller University in Jena (Germany) and Czech Technical University in Prague (Czech Republic). He established collaborations with researchers from different universities across the Europe, USA and India and was supervisor of many M.Sc., Ph.D. and postdoctoral students from Slovenia, Czech Republic, Poland, Iran, Bulgaria, Germany, India and Israel. Since 2009 is the editor of Elsevier book series »Advances in Planar Lipid Bilayers and Liposomes« (APLBL).
Affiliations and Expertise
Full Professor and Head of Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Slovenia
Chandrashekhar Kulkarni
Chandrashekhar V. Kulkarni received his PhD in Chemical Biology from University of London for which he was in receipt of a Marie Curie Early Stage Researcher Fellowship at Imperial College London (2005-2008). Earlier he completed his BSc (1999) and MSc (2001) in Chemistry from Shivaji University Kolhapur, India and started his research career at the National Chemical Laboratory Pune, India. He had a few postdoc stints at University of Graz-Austria, University of Bayreuth-Germany and University of Cambridge-UK during which he worked on a wide range of projects. In March 2013 Dr Kulkarni started ‘Lipid Nanostructures Group’ focussing on highly interdisciplinary and cutting-edge projects. Some of his research interests include complex biomembranes and biomolecule interactions, nanostructured lipid particles as carrier systems, and novel nano-bio-applications of lipid nanostructures. Dr Kulkarni joined the editorial board of APLBL in early 2013 and later as an editor of this book series.
Affiliations and Expertise
University of Central Lancashire, UK
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