Advances in Pharmacological Research and Practice

Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985

1st Edition - January 1, 1986
Editors: J. Knoll, K. Kelemen
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 1 - 4 8 0 1 - 4

Advances in Pharmacological Research and Practice, Volume 1: Pharmacological Protection of the Myocardium presents the proceedings of the 4th Congress of the Hungarian… Read more

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Advances in Pharmacological Research and Practice, Volume 1: Pharmacological Protection of the Myocardium presents the proceedings of the 4th Congress of the Hungarian Pharmacological Society, held in Budapest, Hungary in 1985. This book presents a comprehensive view of the development in the fields of pharmacological protection of the myocardium and the pharmacology of the vascular system. Organized into two sections encompassing 70 chapters, this volume begins with an overview of the ischemic biochemical changes with emphasis on the role of cAMP and the protein kinase system. This text then explores the cellular electrophysiological disorders seen in acute myocardial ischemia as well as their pharmacological modification. Other chapters consider the prevention of primary ventricular fibrillation that includes measures aimed at maintaining electrical stability. The final chapter deals with drugs affecting beneficially the pathological lipoprotein levels. This book is a valuable resource for cardiologists and pharmacologists.

Preface

Section 1 Pharmacological Protection of the Myocardium

Introduction

The Cyclic AMP-Protein Kinase System in Acute Myocardial Ischaemia

Cellular Electrophysiological Disorders in Acute Myocardial Ischaemia and their Modification by Drugs

Antiarrhythmic Effects of Possible Anti-Ischemic Drugs

Protection of the Ischaemic Heart. Prevention of Primary Ventricular Fibrillation

Reflections on the Mode of Action of Beta-Adrenoceptor Antagonists in Prolonging Life After Acute Myocardial Infarction

Cardioprotective and Cerebroprotective Effect of Lipocortin-Like Substances

Antiischaemic Actions of Calcium Antagonists

Cardio-Protective and Nonprotective Effects of Drugs During Anoxia and Reoxygenation

Cardiac Glycosides and Myocardial Ischaemia

Pharmacological Control of Thrombotic Processes for Prevention of Myocardial Ischaemia

The Pharmacological Protection of the Ischaemic Myocardium. Problems and Possibilities

Ethacizine: Antiarrhythmic and Antiischaemic Properties

Effects of Diltiazem and Verapamil in a New Canine Model of Myocardial Infarction

Possible Differences Among the Drug-Induced Responses of the Descending and Circumflex Coronary Arteries in the Anaesthetized Dog

Beta-Adrenolytic Withdrawal Rebound Phenomenon: An Introduction

A Contribution to the Mechanism of Beta-Adrenolytic Withdrawal Syndrome

Alterations in the Efficacy of Beta-Adrenotropic Drugs Due to Changes in the Tone of the Autonomic Nervous System

Arteriovenous Difference in the Inhibition of Platelet Aggregation by the Antianginal Drug: Ch-102

Inhibition of Adenylate Cyclase by Ca2+ in the Ischaemic Myocardium. A Concept of Protection by Ca2+ Channel and β-Blockade

Protective Effect of Calcium Antagonists on Ischaemic Myocardial Metabolism Due to Vasopressin Induced Coronary Spasm

Inhibition of cAMP-Phosphodiesterase from Heart and Coronary Arteries by a New Trapidil Derivative

Comparison of Three Calcium Antagonists, Verapamil, Diltiazem and Fendiline on the Energetic State of Isolated Langendorff Rat Heart

Effect of IS, a Water Soluble Derivative of Indomethacin, on the Outcome of the Very Early Phase of Experimental Myocardial Infarction in Conscious Rats

The Use of Voltage Clamp in the Testing of Antiarrhythmic Drugs

Intracellular Electrophysiological Effects of Amiodarone After Acute and Chronic Application in Guinea Pig Ventricular and Dog Purkinje Fibers

Electrical and Mechanical Activity of the Myocardium as Affected by CH-101, an Antiarrhythmic Agent with Preferential Supraventricular Action

Involvement of the Central Nicotinic Receptors in the Genesis of the Centrogenic Cardiac Arrhythmias in the Rats

Morphine and Tifluadom-Induced Centrogenic Arrhythmias in Anaesthetized Rats

Structure — Antiarrhythmic Activity Relationship of the Amino-Alcohol Derivatives

Long Term Treatment of Cardiac Arrhythmias with Nadolol

Electrophysiological Bases of Antifibrillatory Action of Chinoin-103

Microelectrophysiological Procedure for the Analysis of Drug Effects on the Atrioventricular Conducting System

Serum Levels of Digoxin During Combined Treatment with Digoxin and Amiodarone

The Inotropic Effect of Isoproterenol and Dopamine Under Different Levels of Oxygenation

The Influence of Doxorubicin Combined with Other Drugs on Haemodynamic Parameters in Rabbits

New Antiarrhythmic Agent with Positive Cardiac Actions(GYKI-38 233)

Cardiac Electrophysiological Effects of Lysolecithin, an Ischaemic Metabolite, on Rabbit Atrial and Ventricular Myocardium

Acute and Chronic Effects of Ipratropium Bromide (ITROP) in Patients with Bradycardia

Myocardial Protection by Computerised Long-Time Controlling of the Myocardial Glucose-, Insulin-, Fatty Acid-Supply in Man

List of Contributors

Subject Index

Section 2 Pharmacological Protection of the Vascular System

Chemical and Biochemical Parameters Associated with New Cardiovascular Drugs

Role of Adenosine Receptors

Interactions Between Effects of Adenosine and Inosine in the Coronary Circulation: A New Hypothesis of Metabolic Autoregulation

A Pharmacological Approach to Adenosine Receptors in Myocardium, Sinoatrial Node and Vascular Smooth Muscle

Central Mechanisms and Actions in Hypertension

Adrenergic-Opioid Interactions in Central Cardiovascular and Pain Control

Beta-Endorphin and Antihypertensive Drugs

The Responsiveness of Alpha2-Adrenoceptors in Some Brain Regions of Spontaneous and Vasopressin Hypertensive Rats

Interference of Blood Pressure Variation with the Effect of Antihypertensive Drugs in Normotensive Monkeys Macaca Mulatta

The influence of GABA-ergic System - A New Way in Prophylaxis and Treatment of Hypertension in Experiment

Haemodynamic Interactions Between Guanfacine and Endrallazine in Hypertensive Patients

Role of Calcium Antagonists and Influence of Calcium Fluxes

Role of Calcium Antagonists in the Treatment of Hypertension

The Effect of Calcium Channel Blockers on the Release of Tritiated Noradrenaline from the Pulmonary Artery of Rabbit

Blood Pressure Lowering Effect of Nifedipine: Its Relationship with Exchangeable Body Sodium

Analysis of the Calcium Channel Blockers

Comparative Cardiovascular Effects of Prazosin and Verapamil

Drug Interactions on the Smooth Muscles of the Isolated Spirally Cut Strip of Rat Aorta

Effects of Isoquinoline Derivatives on Cyclic Nucleotides and Calcium Fluxes in Rat Blood Vessels

Role of Vasodilators

Report on the Pharmacological Effects of Three New Peripheral Vasodilator Compounds RGH-0537, RGH-2981 and RGH-2970

Hemodynamic Effects of Vasodilators on Peripheral Circulation

The Influence of Amezinium on Regulation of Arterial Pressure

Circulatory Effects of Fusaric Acid Derivatives

Pharmacological Investigations of the CH-141, a New Isoquinolyl-Oxadiazine Derivative

Role of Alpha-And Beta-Adrenergic and 5-HT Receptors

Regulation of Alpha-Adrenergic Receptors in Dogs' Myocardium and the Coronary Artery

The Effects of Pentacaine and Related Local Anaesthetics on Beta-Adrenergic Receptors and Adenylate Cyclase Activity in Turkey Erythrocyte and Rat Liver Membranes

A Contribution to the Mechanism of Beta-Adrenolytic Withdrawal Syndrome

The Effect of Beta-Adrenoceptor Blocking Drugs on Platelet Aggregation, Calcium Displacement and Fluidization of the Membrane

Effects of Tobanum and Propranolol on Platelet Aggregation Ex Vivo

Interaction of Dihydroergotamine with 5-HT Receptors on Human Blood Platelets and Femoral Veins

Effects of Forskolin, Trequinsine and Isoproterenol on Norepinephrine -Induced Contractions, cAMP and cGMP Levels of Isolated Vascular Tissue

Actions on the Pulmonary Artery

Ouabain Evoked 3(H)-Noradrenaline Release from the Main Pulmonary Artery of the Rabbit

Pharmacological Actions and the Pulmonary Circulation

Influence of the Lipoprotein Level

Effect of a New Benzhydrole Derivative (RGH-2801) on the Lipoprotein and LCAT Level

List of Contributors

Subject Index