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Advances in Pathobiology and Management of Paget’s Disease of Bone presents an essential collection of up-to-date knowledge about the pathophysiology, genetics, and treatment of Paget’s disease. It covers the comprehensive information related to clinical perspectives, epidemiology, genetics, environmental factors such as viral etiology, molecular abnormalities, complications such as osteosarcoma, and current and future treatment for Paget’s disease. This book serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology, and treatment of this disease.
- Discusses the current research of the nature of Paget’s disease and its response to the latest treatments which are seminal in the management of this disease
- Helps users quickly assess the very latest details on the diverse scientific and clinical aspects of Paget’s disease, as opposed to searching through multiple journal articles in the literature
- Presents work from featured leaders in Paget’s disease around the globe
- Serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology, and treatment of this disease
Biomedical researchers, research clinicians, graduate students, and fellows in the fields of endocrinology, bone biology, osteology, and rheumatology
- List of Contributors
- About the Editor
- Chapter 1. Clinical Perspectives of Paget’s Disease of Bone
- Natural History
- Clinical Features and Complications
- Secular Change in Paget’s Disease
- Chapter 2. Viral Etiology of Paget’s Disease of Bone
- Paramyxo-Viral Etiology
- Viral and Genetic Interactions
- Chapter 3. Genetics of Paget’s Disease of Bone
- Importance of Genetic Factors
- Genetic Determinants of Disease Severity
- Clinical Implications
- Chapter 4. Developmental Aspects of Pagetic Osteoclasts
- Increased Sensitivity of OCL Progenitors to Osteotropic Factors
- Increased Nuclei/OCL
- Increased Expression of IL-6
- Increased Irregular Woven Bone Formation Induced by Pagetic OCL
- Chapter 5. Mutant SQSTM1/p62 Signaling in Paget’s Disease of Bone
- RANKL-Induced NFκB Signaling and Osteoclastogenesis
- Defective NFκB Signaling Associated With Mutant SQSTM1/P62
- SQSTM1/P62-Mediated RANKL-Induced AP-1, NFAT, and ERK Signaling
- SQSTM1/P62-Mediated Regulation of Keap1/Nrf2 Signaling
- SQSTM1/P62-Mediated Apoptosis
- SQSTM1/P62-Mediated Autophagy
- SQSTM1/P62 as a Signaling Hub Orchestrating the Interplay Between NFκB, Keap1 and Autophagy
- Chapter 6. Early Onset Pagetic Disorders: Implications for Late-Onset Paget’s Disease of Bone
- Early-Onset Pagetic Syndromes
- Juvenile Paget’s Disease
- Molecular Mechanisms Leading to Early-Onset Pagetic Disorders and Relevance for Late-onset PDB
- Classic PDB: Association With Genes Involved in RANK Signaling and/or Osteoclast Formation
- Classic PDB: Genes Involved in Protein Degradation Pathways
- PDB: A Disorder of Protein Conformation?
- Chapter 7. Osteosarcoma in Paget’s Disease of Bone
- Clinical Presentation
- Treatment and Prognosis
- The Progression From Normal Bone to Paget’s Disease to Pagetic Osteosarcoma
- Genes Differentially Expressed in Paget’s Disease and Pagetic Osteosarcoma
- Chapter 8. Paget’s Disease of Bone: Prognosis and Complications
- Prognosis of Paget’s Disease of Bone
- Bone Complications
- Secondary Osteoarthritis
- Neoplastic Degeneration
- Neurological Complications
- Cardiovascular Complications
- Other Complications
- Chapter 9. Treatment of Paget’s Disease of Bone
- Antipagetic Medications
- Whom to Treat
- No. of pages:
- © Academic Press 2016
- 9th May 2016
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Sakamuri V. Reddy, Ph.D is currently Professor and Director of the Osteoclast Center in the Darby Children’s Research Institute at the Medical University of South Carolina (MUSC), Charleston, SC, USA. Dr. Reddy is a member of the American Society of Bone and Mineral Research (ASBMR) and has over 24 years of experience in studying skeletal disorders and mechanisms of bone loss. His work is focused on osteoclast biology, Paget’s disease of bone, cancer metastasis to bone, and microgravity-induced bone loss. Dr. Reddy received the Young Investigator award from ASBMR in 1992 and the Mitchell I. Rubin Research Award for distinguished scientific contributions to the advancement of medical sciences from MUSC in 2006. Dr. Reddy is presently an Academic Editor for PLOS ONE online journal and has served on the Editorial Board of the Journal of Bone and Mineral Research (JBMR). Additionally, he has served on several grant review panels at the National Institutes of Health (NIH), the Department of Defense (DOD), and other international scientific organizations. He has published nearly 100 peer-reviewed articles in the field of skeletal biology and diseases.
Department of Pediatrics, College of Medicine, Medical University of South Carolina, Charleston, SC, USA
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