Advances in Morphogenesis

Volume 1

1st Edition - January 1, 1961
Editors: M. Abercrombie, Jean Brachet
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 2 4 5 1 - 0

Advances in Morphogenesis, Volume 1 covers the significant advances in various aspects of morphogenesis. This book is composed of nine chapters that include discussion on cell… Read more

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Advances in Morphogenesis, Volume 1 covers the significant advances in various aspects of morphogenesis. This book is composed of nine chapters that include discussion on cell growth, differentiation, and development. The opening chapter describes the complex process of embryonic organization, from the induction initiation to a number of differentiation processes, leading to formation of the essential part of the axial system of the embryo. The next chapters examine the basic aspects of embryology, the process of regeneration in vertebrate, the suppression of growth processes by morphostatic substances, and the role of proteases in tissue regeneration. These topics are followed by discussions on the factors that control plant cell growth and the morphological, physiological, and biochemical studies of normal pigment cell development and differentiation. The concluding chapters explore the development of limbs of tetrapod vertebrates, the morphogenesis of the vertebrate eye, and the particular phases of teleostean egg development. This book is directed toward developmental biologists.

Contributors to Volume 1

Preface

1 Chapter I A Chemical Approach to the Problem of the Organizer

I. Introduction

II. Fine Structure of Embryonic Cells as Revealed by Electron Micrographs

A. Mitochondria

B. Ribonucleoprotein Particles and Cytoplasmic Vesicles

C. Golgi Complex

D. Yolk Platelets

E. Pigment Granules

F. Lipochondria

G. Cell Membrane

H. Nucleus

I. Summary

III. Dorsalization of Subcytolytic Treatments

IV. Chemical Factors Operative in Heterogeneous Induction

V. Inducing Ability of Fresh Samples of Subcellular Components of Amphibian Embryos

VI. RNA and Specific Induction

VII. Transmission of Mediating Factors

VIII. Significance of Some Biochemical Events

IX. Concluding Remarks

References

Chapter II The Embryology of Ascidians

I. Introduction

II. The Biochemical Constituents of the Egg and Their Segregation During Development

A. The Constituents of the Centrifuged Egg

B. The Constituents of the Normal (not Centrifuged) Egg

C. The Segregation of the Egg Constituents in Development

III. The Biological Significance of the Egg Constituents

A. Quantitative Variations of Certain Egg Constituents during Development

B. Specific Inhibition of Enzymatic Activity

C. Heterospecific Hybridizations

IV. Egg Constituents and Morphogenesis

A. The Organ-forming' Potencies of the Unsegmented Egg

B. The 'Mosaic' Character of Development

C. The 'Inductors'

Acknowledgments

References

Chapter III Regeneration of Vertebrate Appendages

I. Introduction

II. Phylogenese Aspects of Regeneration

A. Vertebrate Structures Capable of Regeneration

III. Process of Regeneration

A. Initial Stimulus

B. Dedifferentiation

C. Blastema Formation

D. Differentiation

E. Morphogenesis

IV. Morphogenesis of the Blastema

V. Morphogenetic Influence of the Stump

A. Roles of Individual Tissues

VI. Regeneration from Quantitatively Altered Appendages

A. Regeneration of Double Limbs

B. Regeneration of Half Limbs

C. Partially Irradiated Limbs

VII. Hypomorphic Regeneration

A. Regeneration of Abnormal Extremities

VIII. Polarity and Regeneration

IX. Discussion and Conclusions

References

Chapter IV Action of Morphostatic Substances and the Role of Proteases in Regenerating Tissues and in Tumour Cells

I. Specific Modification of the Growth of Regenerates and Tumors by Chemical Factors

II. Combined Action of Several Inhibitory Substances and the Total Suppression of Growth

A. Selective Suppression of Regenerative Growth by Pairs of Morphostatic Substances

B. Inhibition of an Adenocarcinoma of the Mouse by a Pair of Morphostatic Substances

III. Proteases of Growing Tissues and the Regulation of Growth Processes

A. Morphostatic Substances as Inhibitors of Regenerative Growth and as Activators of Tissue Proteases (Cathepsins)

B. Cathepsins as Regulators of Growth in Normal and Tumorbearing Rats

IV. Aspects of Chemically-induced Growth Inhibition

A. Growth as a Synergistic Process

B. Growth as a Process Integrated in Space and in Time

C. Growth as a Phenomenon of Biochemical Integration

D. Enzymatic Actions of Morphostatic Substances and Structural Effects of Antimitotic Substances

References

Chapter V Determining Factors in Cell Growth: Some Implicationsfor Morphogenesis in Plants

I. Introduction

A. The Fertilized Egg and its Environment

B. Some Problems Posed

II. Phases and Factors in Cell Growth

A. Stimuli to Cell Division in Plants

B. Stimuli to Growth by Cell Enlargement

C. Inhibitors of Cell Division and Cell Enlargement

III. The Regulatory Control of Cell Growth

A. Activation of Quiescent Cells

Β. Polarity and Patterns of Cellular Growth

C. Longevity, Senescence and Death of Cells

IV. Morphogenetic Considerations

A. Apomictic Development

B. Embryogenesis and Related Problems

C. Centers of Growth in the Vegetative Plant Body

D. The Transition from the Vegetative to the Reproductive State

E. Unorganized Versus Organized Growth

V. Summary

Acknowledgments

References

Supplementary List of References