Advances in Molecular Toxicology

Advances in Molecular Toxicology

1st Edition - October 11, 2015

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  • Editors: James C. Fishbein, Jacqueline Heilman
  • eBook ISBN: 9780128024300
  • Hardcover ISBN: 9780128022290

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Description

Advances in Molecular Toxicology features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment and produced by the human body manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.

Key Features

  • Provides cutting-edge reviews by leading workers in the discipline
  • Includes in-depth dissection of the molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines
  • Presents leading-edge applications of technological innovations in chemistry, biochemistry, and molecular medicine

Readership

For academics in the field of chemistry, biochemistry, toxicology, pharmacology and medicine; for Government agencies and those in industry, pharmaceutical and chemical manufacturers

Table of Contents

    • Preface
    • Chapter One: Endocrine-Disrupting Chemicals with Estrogenicity Posing the Risk of Cancer Progression in Estrogen-Responsive Organs
      • Abstract
      • 1 Introduction
      • 2 Signaling Pathways of Estrogen in Estrogen-Responsive Cancers
      • 3 Diverse Effects of EDCs in Estrogen-Responsive Cancers
      • 4 Conclusions
      • Acknowledgments
    • Chapter Two: Molecular Mechanisms in Arsenic Toxicity
      • Abstract
      • 1 Introduction
      • 2 Human Health Effects of Environmental Arsenic Exposure
      • 3 Forms and Metabolism of Environmental Arsenic
      • 4 Molecular Targets of Pentavalent Arsenicals
      • 5 Molecular Targets of Trivalent Arsenicals
      • 6 Conclusions
    • Chapter Three: Molecular Mechanisms of Arsenic Toxicity
      • Abstract
      • 1 Introduction
      • 2 Arsenic Methylation Pathway and Its Products
      • 3 Arsenic Toxicity
      • 4 Cellular Uptake of Arsenicals
    • Chapter Four: Immunomodulation by Environmental Chemicals: Insights into Mammalian Immune Responses to Arsenic, Cadmium, and Lead
      • Abstract
      • 1 Introduction
      • 2 Modulation of Human Immune Responses in Exposure to Environmental Chemicals
      • 3 Modulation of Immune Responses of Model Animals Following Exposure to Environmental Chemicals
      • 4 Disease Symptoms and Host Resistance Following Environmental Chemical Exposure
      • 5 Autoimmunity and Hypersensitivity Following Environmental Chemical Exposure
      • 6 Conclusion
      • Acknowledgments
    • Chapter Five: Plant-Derived Polyphenols: A Chemopreventive and Chemoprotectant Worth-Exploring Resource in Toxicology
      • Abstract
      • 1 Introduction
      • 2 Chemoprevention and Chemoprotection: Beyond Common Cancer Treatments
      • 3 Reactive Oxygen Species: A Main Target of Both Chemopreventive and Chemoprotectant Strategies
      • 4 Plants: An Endless Source of Bioactive Polyphenol Compounds
      • 5 Conclusion
    • Chapter Six: Molecular Mechanisms of Retinal Toxicity Induced by Light and Chemical Damage
      • Abstract
      • 1 Introduction
      • 2 Structure and Function of the Retina
      • 3 Toxicology of the Retina
      • 4 The Retinal Pigment Epithelium
      • 5 Retinoid Visual Cycle
      • 6 Ocular Toxicity by Xenobiotics
      • 7 Compounds Against Retinal Toxicity
      • 8 Conclusions
      • Acknowledgments
    • Chapter Seven: A Photochemical Approach to Fluoroquinolones Toxicity
      • Abstract
      • 1 Introduction
      • 2 Photosensitized Biological Damage by FQs
      • 3 Photochemical Behavior of FQs in Aqueous Media
      • 4 Photochemical Reactions Between FQs and Monomer Units of Biomolecules
      • 5 Photosensitized Protein and DNA Damage by FQs
      • 6 Conclusions
      • Acknowledgments

Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: October 11, 2015
  • Imprint: Academic Press
  • eBook ISBN: 9780128024300
  • Hardcover ISBN: 9780128022290

About the Serial Editors

James C. Fishbein

Dr. James Fishbein works at the Department of Chemistry and Biochemistry, University of Maryland.

Affiliations and Expertise

Department of Chemistry and Biochemistry, University of Maryland, Baltimore, MD, USA

Jacqueline Heilman

Dr. Jacqueline Heilman works at Exponent, Inc., Washington, DC, USA

Affiliations and Expertise

Exponent, Inc., Washington, DC, USA

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