Advances in Metabolic Disorders

Advances in Metabolic Disorders

Volume 3

1st Edition - January 1, 1968

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  • Editors: Rachmiel Levine, Rolf Luft
  • eBook ISBN: 9781483224466

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Advances in Metabolic Disorders, Volume 3 is a compendium of papers that discusses the regulation of ketogenesis, spontaneous diabetes, ethanol-induced hypoglycemia, and hormonal syndromes associated with neoplasia. One paper discusses the primary role of long-chain fatty acids in synergistically controlling enhanced ketogenesis and gluconeogenesis found in the liver at the cellular level. Another paper notes that in rodent experiments, when hypertrophy and hyperplasia are maintained without exhaustion or degeneration and are sufficient in degree, a new equilibrium emerges leading to near-normalization or compensated diabetes. The opposite occurs when hypertrophy and hyperplasia are limited in degree or in duration: decompensation occurs, diabetes progresses. Some papers describe metabolic disorders of the ovary, erythropoietin, and thyroid diseases. One paper analyzes the pathological conditions arising from impairments of the hypothalamic-pituitary-ovarian-uterine axis that can cause disturbances in normal reproduction Another paper investigates if a competitive relationship exists between thyrotropin (TSH) and long-acting thyroid stimulator (LATS). In vivo and in vitro studies show that the effect of LATS are associated mainly with a delayed onset of action. Biochemists, micro-biologists, endocrinologists, and researchers dealing with microchemistry, bacteriology and immunology will find this collection valuable.

Table of Contents

  • Contributors


    Contents of Previous Volumes

    Ketogenesis and its Regulation

    I. Introduction

    II. Biochemistry of the Ketone Bodies

    III. Physiological Considerations in Ketone Formation

    IV. The Practicability of Alloxan Diabetes as a Model for Studying Ketogenesis

    V. Hepatocellular Regulation of Ketone Body Formation

    VI. Relation between Ketogenesis and Gluconeogenesis

    VII. Concluding Comment


    Spontaneous Diabetes and/or Obesity in Laboratory Redents

    I. Introduction

    II. Syndromes in Mice (Mus musculus)

    III. Syndromes in Other Species

    IV. Features Common to Several Syndromes

    V. Conclusions



    Ethanol-Induced Hypoglycemia

    I. Introduction

    II. Characteristics of Ethanol-lnduced Hypoglycemia

    III. Pathogenesis of Ethanol-lnduced Hypoglycemia


    Hormonal Syndromes Associated with Neoplasia

    I. Introduction

    II. Hypoglycemia

    III. Hyperthyroidism

    IV. Precocious Puberty and Inappropriate Gonadotropin Excretion

    V. Hyponatremia

    VI. Erythrocytosis

    VII. Hypercalcemia

    VIII. Ectopic ACTH Syndrome

    IX. Polyfunctional Neoplasms

    X. Humoral Syndromes

    XI. Summary


    Meabolic Disorders of the Ovary

    I. Introduction

    II. Physiology

    III. Abnormal Ovarian Metabolism


    The Nature and Significance of the Long-Acting Thyroid Stimulator

    I. Introduction

    II. Nature of LATS

    III. Significance of LATS


    Thyroid Autoantibodies in Thyroid Diseases

    I. Experimental Autoimmune Thyroiditis

    II. Methods of Demonstrating Thyroid Antibodies in Humans

    III. Occurrence of Thyroid Autoantibodies

    IV. Thyroid Autoantibodies in Other Diseases

    V. Pathogenic Mechanisms



    I. Historical Overview

    II. Assay of Erythropoietin

    III. Chemistry of Erythropoietin

    IV. Organ of Production

    V. Site of Action

    VI. Mechanism of Action

    VII. The Stimulus for Erythropoietin Production

    VIII. Renal Excretion

    IX. The Dynamic Equilibrium of Erythropoiesis

    X. Endocrine Influences on Erythropoiesis; Role of Erythropoietin

    XL Clinical Implications of Erythropoietin

    XII. Conclusion


    Author Index

    Subject Index

Product details

  • No. of pages: 348
  • Language: English
  • Copyright: © Academic Press 1968
  • Published: January 1, 1968
  • Imprint: Academic Press
  • eBook ISBN: 9781483224466

About the Editors

Rachmiel Levine

Rolf Luft

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