Advances in Metabolic Disorders - 1st Edition - ISBN: 9781483167480, 9781483194967

Advances in Metabolic Disorders

1st Edition

Volume 1

Editors: Rachmiel Levine Rolf Luft
eBook ISBN: 9781483194967
Imprint: Academic Press
Published Date: 1st January 1964
Page Count: 380
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Advances in Metabolic Disorders, Volume 1 presents the application of biochemistry to the pathogenesis of human diseases. This book discusses the parathormone physiology and its deviations, as well as the origins and course of osteoporosis. The introductory chapters deal with the catabolism of glycogen; physiology of parathyroids; multiple enzymic defects; biochemical technology of glycogen storage disease; assay of parathyroid hormone; mechanisms of mitochondrial respiratory control; pathogenesis of primary osteoporosis; and nature of bone change. The subsequent chapters consider the definition and physiology of insulin antagonists and chemistry of parathyroid hormone. These topics are followed by discussions of the physiologic effects of aldosterone and the metabolic interrelationship between folate and vitamin B12 are presented. A chapter is devoted to the definition and treatment of hypoparathyroidism and hyperparathyroidism. The remaining chapters focus on the diagnosis of insulin antagonists in tissues, plasma, and serum.
The book can provide useful information to doctors, students, and researchers.

Table of Contents



Glycogen Storage Disease

I. Introduction

II. The Catabolism of Glycogen

III. General Considerations on Glycogen Storage Disease

IV. Glycogenosis Related to a Phosphorylase Deficiency

V. Limit Dextrinosis (Defect of Amylo-1, 6-Glucosidase)

VI. Glycogenosis Related to the Absence of Glucose-6-Phosphatase

VII. Glycogenosis Related to the Absence of Acid Maltase (Pompe's Disease)

VIII. Amylopectinosis (Andersen's Disease)

IX. Multiple Enzymic Defects

X. Other Disturbances of Glycogen Metabolism

XI. Biochemical Technology of Glycogen Storage Disease

XII. General Discussion


The Parathyroids

I. Introduction

II. Physiology

III. Assay of Parathyroid Hormone

IV. Chemistry of Parathyroid Hormone

V. Biochemical Aspects of Parathyroid Hormone Action

VI. Hyperparathyroidism

VII. Hypoparathyroidism


Mitochondrial Respiratory Control: Biochemical PhysiologicalL, and Pathological Aspects Lars Ernster and Rolf Luft

I. Introduction

II. Biochemical Mechanisms

III. Physiological and Pathological Aspects

IV. Conclusions



I. Definition and Classification

II. Clinical Picture and Incidence

III. Diagnosis

IV. Nature of Bone Change

V. Pathogenesis of Primary Osteoporosis

VI. Secondary Osteoporosis

VII. Therapy

VIM. Conclusions


Basal Metabolic Rate and Thyroid Hormones

I. Introduction

II. The Determination of BMR

III. Thyroid Hormones and the Regulation of BMR

IV. Mode of Action of Thyroid Hormones


Insulin Antagonists and Inhibitors

I. Introduction: Definition and Physiological Insulin Antagonists

II. Insulin Antagonists in Tissues

III. Insulin Antagonists in Plasma and Serum

IV. Inhibitors of Glucose Uptake

V. Discussion and Implications


Aldosterone: Its Biochemistry and Physiology

I. Introduction

II. Biochemistry

III. Physiologic Effects of Aldosterone

IV. Abnormal Aldosterone Secretion in Disease and Its Implications

V. The Basic Problem: Mechanism for Normal Control of Aldosterone Secretion

VI. Could Angiotensin Be the Trophic Hormone for Aldosterone?


Foloc Acid Deficiency in Man and its Interrelationship with VitaminN B12 Metabolism

Part 1. Introduction

Part 2. General and Historical Survey

I. Historical Review of the Relationship of Folic Acid and Vitamin B12 to the Megaloblastic Anemias

II. Distribution, Chemistry, and Absorption of Food Folate

III. The Metabolic Functions of the Folate Coenzymes

IV. The Interrelationships of the Folate Coenzymes

V. Metabolic Reactions of Vitamin 812 and Site of Interaction with Folate in Mammals

Part 3. Methodology

I. Cytological Criteria of Megaloblastic Anemia

II. The Therapeutic Trial As an Index of Specific Deficiency

III. Newer Methods to Evaluate the Intermediary Metabolism and Physiology of Folates

Part 4. Appraisal of Folate Deficiency and Metabolism in Megaloblastic

Anemias and Other Clinical Disorders

I. Clinical Diagnostic Experience with Various Parameters of Folate Deficiency

II. Incidence of Folate Deficiency

III. Nutritional Requirement and Metabolic Turnover of Folate

IV. Metabolic Interrelationship between Folate and Vitamin


Addendum to the Paper "Glycogen Storage Disease"

Author Index

Subject Index


No. of pages:
© Academic Press 1964
Academic Press
eBook ISBN:

About the Editor

Rachmiel Levine

Rolf Luft

Ratings and Reviews