Advances in Metabolic Disorders

Advances in Metabolic Disorders

Including the Proceedings of a Symposium on Insulin, Held at the City of Hope Medical Center, Duarte, California, 1972

1st Edition - September 28, 1974

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  • Editors: Rachmiel Levine, Rolf Luft
  • eBook ISBN: 9781483215495

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Advances in Metabolic Disorders, Volume 7 covers the developments in the study of metabolic disorders. The book discusses the role of growth hormone on the stimulation of somatomedin in the tissues; the secretion of natriuretic hormones by extracellular volume expansion; and the methodological aspects on the estimation of genetic effects of environmental agents in man. The text also describes the metabolic aspects of desert adaptation by man and the synthesis and secretion of insulin in dynamic perfusion systems. The general morphological and functional aspects of islet cells as well as the mechanisms involved in the release of insulin from the beta cell are also considered. The book further tackles the mechanisms of insulin action; diabetes mellitus as a disease of pancreatic and extrapancreatic origin; and the pathogenesis of pancreatic islet cell hyperplasia and insulin insensitivity in obesity. The text concludes by looking into the clinical correlation of obesity and diabetes mellitus. The book will prove invaluable to endocrinologists, biochemists, physicians, and medical students.

Table of Contents

  • Contributors

    Contents of Previous Volumes

    Growth Hormone and Somatomedin

    I. Introduction

    II. Sulfation Factor—Somatomedin

    III. Bioassay of Somatomedin

    IV. Occurrence of Somatomedin in Serum

    V. Purification of Somatomedin

    VI. Mechanism of Production of Somatomedin

    VII. Biological Action of Purified Somatomedin in Vitro

    VIII. Relations between Somatomedins and Other Growth Factors

    IX. Conclusions


    Natriuretic Hormones

    I. Introduction

    II. An Outline of Current Concepts of the Regulation of Renal Sodium Excretion

    III. Cross-Circulation and Related Studies

    IV. In Vitro Assays

    V. "Natriuretic" Assays

    VI. Other Natriuretic Agents

    VII. Site of Secretion and Chemical Nature

    VIII. Speculations


    Methodological Aspects on the Estimation of Genetic Effects of Environmental Agents in Man

    I. Introduction

    II. Changes in Selection

    III. Changes in Mutation Frequency

    IV. Parameters That Possibly Might Reflect Changes in the Genetic Material

    V. Summary


    Metabolic Aspects of Desert Adaptation (Man)

    I. Introduction

    II. Methodology of Energy Metabolism Studies

    III. Adaptive Changes in Man's Basal Metabolism in Hot Environment

    IV. Man's Body Temperature, Energy Expenditure, and Work Capacity in Desert Climate

    V. Food Intake, Nutrients, and Water Metabolism in Desert Conditions

    VI. Acid-Base Balance in Blood of Man in the Desert

    VII. The Endocrine Background for Metabolic Changes under Desert Conditions

    VIII. Some Insights into the Cellular Mechanisms of the Metabolic Changes during Exposure to Heat


    Proceedings of a Symposium on Insulin - City of Hope Medical Center, Duarte, California, February 13, 1972

    Philosophy and Outlook


    Synthesis and Secretion of Insulin in Dynamic Perfusion Systems

    I. Introduction

    II. Materials and Methods

    III. Results and Discussion

    IV. Summary



    Structure and Function of the Endocrine Cell Types of the Islets

    I. Introduction

    II. Morphology and Hormones of the Islets of Langerhans

    III. Formation of Insulin in the Beta Cell

    IV. Insulin Release from the Beta Cell

    V. Microfilaments in Beta Cell Secretion

    VI. Glucoreceptor of the Beta Cell

    VII. Possible Defects in Insulin Release in the Diabetic Subject

    VIII. Islet Transplantation



    Mechanisms of Insulin Action

    I. Introduction

    II. Factors under Consideration

    III. Current Hypotheses Being Tested



    Diabetes Mellitus—A Disease of Pancreatic and Extrapancreatic Origin

    I. Introduction

    II. The Mechanisms of the Deranged Insulin Secretion

    III. Metabolic Consequences of Low Insulin Response (in Nondiabetic Subjects)

    IV. Factors Involved in the Transition from Prediabetes to Diabetes

    V. Future Aspects of the Prevention and Treatment of Diabetes

    VI. Conclusions



    The Pathogenesis of Pancreatic Islet Cell Hyperplasia and Insulin Insensitivity in Obesity

    I. Introduction

    II. Factors Influencing Islet Function in Obesity

    III. The Development of Insulin Insensitivity in Obesity

    IV. Speculations and Conclusions



    Obesity and Diabetes Mellitus

    I. Pathophysiological Features of Obesity

    II. Clinical Correlation of Obesity and Diabetes Mellitus

    III. Treatment of Obesity and Prevention of Diabetes by Elimination of Hyperinsulinism

    IV. Summary



    Subject Index

Product details

  • No. of pages: 278
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: September 28, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9781483215495

About the Editors

Rachmiel Levine

Rolf Luft

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