Advances in Lipid Research

1st Edition, Volume 3 - January 1, 1965
Editors: Rodolfo Paoletti, David Kritchevsky
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 2 4 4 2 - 8

Advances in Lipid Research, Volume 3 presents the analysis of human serum lipoproteins and emphasizes the possibilities inherent in the application of computer methods to such… Read more

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Advances in Lipid Research, Volume 3 presents the analysis of human serum lipoproteins and emphasizes the possibilities inherent in the application of computer methods to such analyses. This book discusses the effects of various drugs on the other important component of the serum lipids, the phospholipids. Organized into six chapters, this volume begins with an overview of the possibility of a dehydrogenation toward the methyl group. This text then presents a detailed discussion of lipoprotein structure, metabolism, and catabolism. Other chapters consider some potentially significant revisions in lipoprotein procedure, including additions to the technology of lipoprotein analysis. This book discusses as well the chemistry and metabolism of plasma lipoprotein as related to physiological and disease states. The final chapter deals with the advances in methods of purification and studies of the properties and mode of action of lipases. This book is a valuable resource for organic chemists, neurochemists, and biochemists.

Contributors to this Volume

Preface

The Metabolism of Polyenoic Fatty Acids

I. The Transformation of Oleic Acid into △5,8,11-C20-Trienoic Acid

II. The Inconvertibility of One Type of Polyenoic Acid into Another

III. The Behavior of the Isomers of Linoleic and Linolenic Acids

IV. The Combustibility of the Polyenoic Acids

Addendum: Preparation by Total Synthesis of Unsaturated, Especially Polyenoic, Fatty Acids

References

The Analysis of Human Serum Lipoprotein Distributions

I. Introduction and General Considerations of Human Serum Lipoprotein Analysis

II. Some Unique Problems of Ultracentrifugal Lipoprotein Isolation and Flotation Analysis

III. A Generalized Method for the Computer Analysis of Lipoprotein Distributions

IV. Application of Computer Analysis to a Series of Adult Normal Males and Females

V. Potential Improvements in the Computer Methodology for Lipoprotein Analysis

References

Factors Affecting Lipoprotein Metabolism

I. Introduction

II. Physical and Chemical Properties of Plasma Lipoproteins

III. Experimental Approach to Lipoprotein Structure

IV. Biosynthesis of Plasma Lipoproteins

V. Catabolism of Plasma Lipoproteins

VI. Significance of Lipoproteins in Fat Transport

VII. Concluding Remarks

References

The Action of Drugs on Phospholipid Metabolism

I. Introduction

II. Excitants and Antidepressants

III. Depressants

IV. Glycosides

V. Pharmacologically Active Phospholipids

References

Brain Sterol Metabolism

I. Introduction

II. Distribution of Sterols in the Developing Brain

III. Distribution of Cholesterol in the Adult Mammalian Brain

IV. Brain Cholesterol Metabolism

V. Brain Sterols: The Effects of Drugs

VI. Brain Cholesterol: The Effects of Malnutrition

VII. Brain Sterols: The Effects of Disease

VIII. Conclusion

References

Lipases

I. Introduction

II. Distribution of Lipases

III. Methods of Determining Lipase Activity

IV. Purification

V. Substrate Specificity and Mode of Action

VI. Factors Affecting the Velocity of Hydrolysis

VII. Lipoprotein Lipase

VIII. Summary

References

Author Index

Subject Index