Advances in Lipid Research

Advances in Lipid Research

1st Edition - January 1, 1964

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  • Editors: Rodolfo Paoletti, David Kritchevsky
  • eBook ISBN: 9781483224411

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Advances in Lipid Research, Volume 2 provides a discussion of theories of triglyceride structure and presents a provocative comparison of in vitro versus in vivo lipid biosynthesis. This book covers brain phosphoinositide research, synthesis of phosphoglycerides, and the chemistry of lapoamino acids and phosphatidylglycerols. Organized into eight chapters, this volume begins with an overview of the procedure for calculating the percentages of the individual triglycerides as well as for triglyceride families. This text then examines the complex field of bacterial lipids. Other chapters consider the two aspects of the relationship between lipid metabolism and atherosclerosis. This book discusses as well the lipolytic and esterolytic activity of various tissues in connection with lipid transport and its relevancy to the development of atherosclerosis. The final chapter deals with the methods best adopted for in vitro and in vivo investigations of lipid biosynthesis. This book is a valuable resource for phospholipid chemists, biochemists, and scientists.

Table of Contents

  • Contributors to this Volume


    Triglyceride Structure

    I. General

    II. The 1,3 Random, 2 Random Distribution Hypothesis

    III. The Validity of the 1,3 Random, 2 Random Distribution Hypothesis

    IV. Mechanisms


    Bacterial Lipids

    I. Introduction

    II. Lipid Composition of Whole Cells

    III. Intracellular Distribution of Lipids

    IV. Biosynthesis of Lipid Components


    Phosphatidylglycerols and Lipoamino Acids

    I. General Introduction

    II. Phosphatidylglycerols

    III. Lipoamino Acids


    The Brain Phosphoinositides

    I. Introduction

    II. Methods of Separation and Analysis

    III. Chemistry of the Brain Inositides

    IV. Enzymatic Breakdown

    V. Biosynthesis

    VI. Physiological Significance of Brain Inositides


    The Synthesis of Phosphoglycerides and Some Biochemical Applications

    I. Introduction

    II. Synthesis of Phosphatidylcholine

    III. Synthesis of Phosphatidylethanolamine

    IV. Synthesis of Phosphatidylserine

    V. Synthesis of Miscellaneous Types of Phosphoglycerides and Derivatives

    VI. Application of Synthetic Phosphoglycerides in Biochemical Problems

    VII. Concluding Comments


    The Lipolytic and Esterolytic Activity of Blood and Tissues and Problems of Atherosclerosis

    I. Introduction

    II. Mast Cells, Lipid Transport, and Atherosclerosis

    III. Effects of Protamine Sulfate Administration

    IV. Some Observations on the Clearing Factor and Human Atherosclerosis

    V. The Relationship between Lipoprotein Lipase, Postherapin Esterase, and Other "Clearing Factor Enzymes"

    VI. Lipolytic and Esterolytic Activity of Tissues

    VII. Concluding Remarks


    Evaluation of Drugs Active Against Experimental Atherosclerosis

    I. Introduction

    II. Experimental Atherosclerosis

    III. Cholesterol Synthesis Inhibitors

    IV. Acceleration of Cholesterol Degradation and Excretion

    V. Sterols Related to Cholesterol

    VI. Estrogens and Related Compounds

    VII. Androgens and Related Compounds

    VIII. Thyroid Hormones and Analogs

    IX. Adrenal and Pituitary Hormones

    X. Hypotensive Agents

    XI. Vitamins and Atherogenesis

    XII. Unsaturated Fatty Acids

    XIII. Lipoprotein Lipase and Heparin

    XIV. Thrombosis, Fibrinolysis, and Anticoagulation

    XV. Conclusions


    Comparative Evaluation of Lipid Biosynthesis in Vitro and in Vivo

    I. Introduction

    II. Study of Precursors

    III. The Enzymatic Systems and the Mechanisms of Synthesis

    IV. Localization of Synthesis

    V. The Qualitative and Quantitative Regulation of Fatty Acid Synthesis

    VI. Conclusion


    Author Index

    Subject Index

Product details

  • No. of pages: 512
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9781483224411

About the Editors

Rodolfo Paoletti

David Kritchevsky

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