Advances in Lipid Research - 1st Edition - ISBN: 9780120249145, 9781483215365

Advances in Lipid Research, Volume 14

1st Edition

Editors: Rodolfo Paoletti David Kritchevsky
eBook ISBN: 9781483215365
Imprint: Academic Press
Published Date: 28th March 1976
Page Count: 288
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Table of Contents

List of Contributors


Contents of Previous Volumes

Regulation of HMG-CoA Reductase

I. Introduction

II. Unique Role of HMG-CoA Reductase in Sterol Biosynthesis

III. Distribution of HMG-CoA Reductase

IV. Assay of HMG-CoA Reductase Activity

V. Solubilized Mammalian Liver Microsomal HMG-CoA Reductase

VI. Diurnal Rhythm of Mammalian Liver HMG-CoA Reductase

VII. Developmental Pattern of Rat Liver HMG-CoA Reductase

VIII. Hormonal Effects on HMG-CoA Reductase

IX. Modulation of HMG-CoA Reductase Activity

X. Regulation of Mammalian HMG-CoA Reductase by Steroids

XI. Familial Hypercholesterolemia

XII. Microbial HMG-CoA Reductases

XIII. Conclusion


Fatty Acid Activation: Specificity, Localization, and Function

I. Introduction

II. Assays for Acyl-CoA Synthetases

III. Reaction Mechanism

IV. Substrate Specificity of Acyl-CoA Synthetases

V. Subcellular Localization of Acyl-CoA Synthetases

VI. Organ Distribution of Acyl-CoA Synthetases

VII. Function and Regulation of Acyl-CoA Synthetases

Note Added in Proof


Polyene Antibiotic-Sterol Interaction

I. Introduction

II. Structures and Chemical Properties of Polyene Antibiotics

III. Biological Properties of Polyene Antibiotics

IV. Molecular Basis of Polyene Antibiotics—Interaction with Membrane Sterols

V. Polyene Antibiotics in the Study of Membrane Structure-Function Relationships

VI. Concluding Remarks


The Lipids of Plant Tissue Cultures

I. Introduction

II. The Plant Tissue Culture Technique

III. Total Lipids of Plant Tissue Cultures

IV. Fatty Acid Patterns of Lipids in Plant Tissue Cultures

V. Variables Affecting the Lipids of Plant Tissue Cultures

VI. Applications of Plant Tissue Cultures

VII. Summary and Conclusion


Synthesis of Some Acylglycerols and Phosphoglycerides

I. Introduction

II. General Considerations

III. Racemic Acylglycerols

IV. Synthesis of Enantiomeric Acylglycerols

V. Synthesis of Phosphoglycerides

VI. Summary


Author Index

Subject Index


Advances in Lipid Research, Volume 14 is a five-chapter text that covers other important aspects of lipid chemistry, including an enzyme controlling cholesterol biogenesis, fatty acid activation, and lipid synthesis.

The first chapter concerns with the control of activity of ?-hydroxy-?-methylglutaryl coenzyme A reductase. The second chapter deals with the specificity, localization, and function of fatty acid activation. The third chapter describes the interaction between polyene antibiotics and sterols. This chapter specifically tackles some antibiotic activity to understand membrane function and in vivo hypolipidemic activity. The fourth chapter focuses on the lipids in plant cultures, while the fifth chapter looks into the methods of synthesis of acylglycerols and phosphoglycerides.

This book will prove useful to lipid chemists, biochemists, and researchers.


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© Academic Press 1976
Academic Press
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About the Editors

Rodolfo Paoletti Editor

David Kritchevsky Editor