Advances in Lipid Research

Advances in Lipid Research

1st Edition - October 28, 1974

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  • Editors: Rodolfo Paoletti, David Kritchevsky
  • eBook ISBN: 9781483215341

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Advances in Lipid Research, Volume 12 is a seven-chapter text that focuses on the significant progress in lipid metabolism. The opening chapter reviews the relationships between plasma and tissue lipids and atherosclerosis. Understanding the dynamics of exchange of plasma lipoproteins with aortic tissue is the basis of understanding the etiology of this disease and the approaches to therapy. The succeeding chapters describe the phases of lipid metabolism in cultured cells and the influences of various dietary components on the specific enzymes of fatty acid and cholesterol biogenesis. Other chapters discuss the role of phospholipids in transport and enzymic reactions, membrane fluidity, aspects of lipid-protein interactions, and the physiologic role of thyroid lipids. The closing chapters explore the chemistry and biological function of glycosyl glycerides, as well as the physiopathology of the biguanidines, a class of oral hypoglycemic agents. This book will prove useful to lipid chemists, biochemists, and researchers.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    The Relationship Between Plasma and Tissue Lipids in Human Atherosclerosis

    I. Introduction

    II. Relationship Between the Chemical and Morphological Characteristics of Lipid in Human Aortic Intima

    III. Concentration of Plasma LD-Lipoprotein in Normal Intima and Lesions

    IV. Quantitative Relationship Between Plasma Constituents in Intima

    V. Relationship Between LD-Lipoprotein and the Lipid "Deposited" in Intima

    VI. Conclusions


    Lipid Metabolism in Cultured Cells

    I. Introduction

    II. Methodology

    III. Fatty Acids

    IV. Glycerides

    V. Sterols

    VI. Phospholipids

    VII. Lipid Ethers

    VIII. Studies of Drugs and Inhibitors of Lipid Metabolism in Cultured Cells

    IX. Studies of Lipids in Differentiated Cells in Culture

    X. Use of Cell Cultures for the Study of Lipidoses

    XI. Comparison of Lipid Metabolism in Normal and Tumor Cells in Culture

    XII. Summary and Conclusions


    Effect of Diet on Activity of Enzymes Involved in Fatty Acid and Cholesterol Synthesis

    I. Introduction

    II. Dietary Adaptation of Specific Enzymes Involved in Fatty Acid and Cholesterol Synthesis

    III. Overview


    Role of Phospholipids in Transport and Enzymic Reactions

    I. Introduction

    II. Criteria for Establishing and Determining the Role of Lipids in Biological Processes

    III. Nonspecific Role of Lipids in Biological Processes

    IV. Effect of Membrane Fluidity and Lipid Phase Transitions on Functioning of Membrane-Bound Proteins

    V. Specific Role of Lipids

    VI. Partially Characterized Aspects of Lipid-Protein Interactions

    VII. Epilogue and Prospects


    The Composition and Possible Physiologie Role of the Thyroid Lipids

    I. Introduction

    II. Methods and Materials

    III. Results

    IV. Discussion

    V. Summary


    Glycosyl Glycerides

    I. Introduction

    II. Discovery and Elucidation of Structure

    III. Isolation and Analytical Methodology

    IV. Occurrence and Distribution

    V. Chemical Synthesis

    VI. Metabolism in Plants, Bacteria, and Animals

    VII. Biological Function


    Inhibition of Fatty Acid Oxidation by Biguanides: Implications for Metabolic Physiopathology

    I. Introduction

    II. Preliminary Pharmacobiological Criteria

    III. Glucose Turnover and Oxidation

    IV. Gluconeogenesis

    V. Peripheral Glucose Utilization

    VI. Secondary Hyperinsulinemia

    VII. Intestinal Glucose Absorption

    VIII. Lactate Metabolism

    IX. Adipose Tissue Metabolism

    X. Hyperlipoproteinemia

    XI. Nitrogen Metabolism

    XII. Relationships Between Biguanides and Insulin

    XIII. A Further Hypothesis

    XIV. Conclusions

    XV. Summary


    Author Index

    Subject Index

Product details

  • No. of pages: 436
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: October 28, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9781483215341

About the Editors

Rodolfo Paoletti

David Kritchevsky

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