Advances in Lipid Research

Advances in Lipid Research

Skin Lipids

1st Edition - November 14, 1991

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  • Editor: Peter M. Elias
  • eBook ISBN: 9781483215457

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Advances in Lipid Research, Volume 24 provides information pertinent to the fundamental aspects of skin lipids. This book discusses the importance of epidermal lipids for cutaneous barrier function. Organized into 11 chapters, this volume begins with an overview of the biochemical, metabolic, and structural aspects of the role of lipids in permeability barrier formation and maintenance. This text then examines the lipid biophysics of the intercellular lipid domains in the stratum corneum, and the regulation of percutaneous absorption by these domains. Other chapters consider the lipid content and metabolism of cultured keratinocytes, which are grown under standard conditions and in various in vitro systems that attempt to produce an epidermal equivalent. This book discusses as well the important field of lipid signaling mechanisms in the epidermis. The final chapter deals with the clinical, pathophysiological, and therapeutic applications of vitamin D. This book is a valuable resource for chemist, cytochemists, and clinicians.

Table of Contents

  • Preface

    Structural and Lipid Biochemical Correlates of the Epidermal Permeability Barrier

    I. Introduction and Historical Perspective

    II. Stratum Corneum Two-Compartment Model

    III. Cellular Basis for Lipid-Protein Sequestration in the Stratum Corneum of Terrestrial Mammals

    IV. Insights from Aves and Marine Mammals (Cetaceans)

    V. Intercellular Membrane Structures in Mammalian Stratum Corneum

    VI. Structural Alterations in Pathological Stratum Corneum

    VII. Structural-Lipid Biochemical Correlates

    VIII. Summary


    The Biochemistry and Function of Stratum Corneum Lipids

    I. Introduction

    II. Historical Overview

    III. Biochemistry and Function

    IV. Essential Fatty Acid Metabolism

    V. Fatty Acid Uptake and Binding


    The Regulation and Role of Epidermal Lipid Synthesis

    I. Introduction

    II. Methodological Considerations

    III. Lipid Synthesis in the Skin

    IV. Systemic Regulation of Epidermal Lipid Synthesis

    V. Local Regulation of Epidermal Lipid Synthesis-Role of the Barrier

    VI. Importance of Epidermal Lipid Synthesis for Barrier Repair

    VII. Signals Initiating Barrier Repair

    VIII. Local Regulation of Epidermal Lipid Synthesis-Potential Role of Cell Proliferation

    IX. Summary


    Lipid Metabolism in Cultured Keratinocytes

    I. Introduction

    II. Changes in LDL Receptor Expression and in Regulation of Cholesterol Synthesis in Relation to Keratinocyte Differentiation

    III. Differentiation-Linked Changes in the Rate of Lipid Synthesis: Effect of Extracellular Lipoproteins

    IV. Differentiation-Linked Modulations of Keratinocyte Lipid Composition

    V. Changes in the Plasma Membrane Lipid Composition and Fluidity in Relation to Keratinocyte Differentiation

    VI. Retinoid-Induced Modulations of Lipid Composition in Cultured Keratinocytes

    VII. Conclusion

    VIII. Appendix


    Lipid Modulators of Epidermal Proliferation and Differentiation

    I. Introduction

    II. Ether Phospholipids: Platelet-Activating Factor

    III. Phospholipase-Initiated Signaling Mechanisms

    IV. Sphingolipids as Effector Molecules

    V. Miscellaneous Lipid Effectors

    VI. Summary


    X-Ray Diffraction and Electron Paramagnetic Resonance Spectroscopy of Mammalian Stratum Corneum Lipid Domains

    I. Introduction

    II. X-Ray Diffraction

    III. Electron Paramagnetic Resonance

    IV. Conclusions


    Strategies to Enhance Permeability via Stratum Corneum Lipid Pathways

    I. Introduction

    II. In Vitro Studies

    III. In Vivo Studies: Use of Attenuated Total Reflectance Infrared Spectroscopy to Evaluate the SC

    IV. Conclusion


    Lipids in Normal and Pathological Desquamation

    I. Introduction

    II. Cholesterol and Sterol Metabolites in Desquamation

    III. Fatty Acids and Acyl Lipids in Desquamation

    IV. Possible Lipid Metabolic Defects in Other Cornification Disorders

    V. Conclusion: Lipid and Nonlipid Effectors of Desquamation


    Chemistry and Function of Mammalian Sebaceous Lipids

    I. Introduction

    II. Anatomy and Distribution

    III. Comparative Chemistry of Cutaneous Lipids

    IV. Analysis of Sebum

    V. Physiology of Sebum Secretion

    VI. Biochemistry of Sebum

    VII. Function of Sebum


    Integumental Lipids of Plants and Animals: Comparative Function and Biochemistry

    I. Introduction

    II. General Design of Surface Lipids

    III. Composition and Structure of Integumental Lipids

    IV. Synthesis and Transport of Integumental Lipids

    V. Water Barrier Function: Working Models


    Epidermal Vitamin D Metabolism, Function, and Regulation

    I. Introduction

    II. Historical Perspective

    III. Chemistry of Vitamin D

    IV. Role of Vitamin D in Calcium Homeostasis

    V. Other Biological Actions of 1,25-(OH)2D3

    VI. Mechanism of Action of 1,25-(OH)2D3

    VII. Cutaneous Production of Vitamin D

    VIII. Production of 1,25-(OH)2D3 and Its Regulation

    IX. Production of 1,25-(OH)2D3 by Epidermal Cells in Culture

    X. Effects of 1,25-(OH)2D3 on Growth and Differentiation of Keratinocytes

    XI. Mechanism of Action of 1,25-(OH)2D3 in the Regulation of Epidermal Differentiation

    XII. Effect of 1,25-(OH)2D3 on Other Types of Skin Cells

    XIII. Concluding Remarks



    Contents of Previous Volumes

Product details

  • No. of pages: 366
  • Language: English
  • Copyright: © Academic Press 1991
  • Published: November 14, 1991
  • Imprint: Academic Press
  • eBook ISBN: 9781483215457

About the Editor

Peter M. Elias

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