Advances in Lipid Research
Skin Lipids
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Advances in Lipid Research, Volume 24 provides information pertinent to the fundamental aspects of skin lipids. This book discusses the importance of epidermal lipids for cutaneous barrier function. Organized into 11 chapters, this volume begins with an overview of the biochemical, metabolic, and structural aspects of the role of lipids in permeability barrier formation and maintenance. This text then examines the lipid biophysics of the intercellular lipid domains in the stratum corneum, and the regulation of percutaneous absorption by these domains. Other chapters consider the lipid content and metabolism of cultured keratinocytes, which are grown under standard conditions and in various in vitro systems that attempt to produce an epidermal equivalent. This book discusses as well the important field of lipid signaling mechanisms in the epidermis. The final chapter deals with the clinical, pathophysiological, and therapeutic applications of vitamin D. This book is a valuable resource for chemist, cytochemists, and clinicians.
Table of Contents
Preface
Structural and Lipid Biochemical Correlates of the Epidermal Permeability Barrier
I. Introduction and Historical Perspective
II. Stratum Corneum Two-Compartment Model
III. Cellular Basis for Lipid-Protein Sequestration in the Stratum Corneum of Terrestrial Mammals
IV. Insights from Aves and Marine Mammals (Cetaceans)
V. Intercellular Membrane Structures in Mammalian Stratum Corneum
VI. Structural Alterations in Pathological Stratum Corneum
VII. Structural-Lipid Biochemical Correlates
VIII. Summary
References
The Biochemistry and Function of Stratum Corneum Lipids
I. Introduction
II. Historical Overview
III. Biochemistry and Function
IV. Essential Fatty Acid Metabolism
V. Fatty Acid Uptake and Binding
References
The Regulation and Role of Epidermal Lipid Synthesis
I. Introduction
II. Methodological Considerations
III. Lipid Synthesis in the Skin
IV. Systemic Regulation of Epidermal Lipid Synthesis
V. Local Regulation of Epidermal Lipid Synthesis-Role of the Barrier
VI. Importance of Epidermal Lipid Synthesis for Barrier Repair
VII. Signals Initiating Barrier Repair
VIII. Local Regulation of Epidermal Lipid Synthesis-Potential Role of Cell Proliferation
IX. Summary
References
Lipid Metabolism in Cultured Keratinocytes
I. Introduction
II. Changes in LDL Receptor Expression and in Regulation of Cholesterol Synthesis in Relation to Keratinocyte Differentiation
III. Differentiation-Linked Changes in the Rate of Lipid Synthesis: Effect of Extracellular Lipoproteins
IV. Differentiation-Linked Modulations of Keratinocyte Lipid Composition
V. Changes in the Plasma Membrane Lipid Composition and Fluidity in Relation to Keratinocyte Differentiation
VI. Retinoid-Induced Modulations of Lipid Composition in Cultured Keratinocytes
VII. Conclusion
VIII. Appendix
References
Lipid Modulators of Epidermal Proliferation and Differentiation
I. Introduction
II. Ether Phospholipids: Platelet-Activating Factor
III. Phospholipase-Initiated Signaling Mechanisms
IV. Sphingolipids as Effector Molecules
V. Miscellaneous Lipid Effectors
VI. Summary
References
X-Ray Diffraction and Electron Paramagnetic Resonance Spectroscopy of Mammalian Stratum Corneum Lipid Domains
I. Introduction
II. X-Ray Diffraction
III. Electron Paramagnetic Resonance
IV. Conclusions
References
Strategies to Enhance Permeability via Stratum Corneum Lipid Pathways
I. Introduction
II. In Vitro Studies
III. In Vivo Studies: Use of Attenuated Total Reflectance Infrared Spectroscopy to Evaluate the SC
IV. Conclusion
References
Lipids in Normal and Pathological Desquamation
I. Introduction
II. Cholesterol and Sterol Metabolites in Desquamation
III. Fatty Acids and Acyl Lipids in Desquamation
IV. Possible Lipid Metabolic Defects in Other Cornification Disorders
V. Conclusion: Lipid and Nonlipid Effectors of Desquamation
References
Chemistry and Function of Mammalian Sebaceous Lipids
I. Introduction
II. Anatomy and Distribution
III. Comparative Chemistry of Cutaneous Lipids
IV. Analysis of Sebum
V. Physiology of Sebum Secretion
VI. Biochemistry of Sebum
VII. Function of Sebum
References
Integumental Lipids of Plants and Animals: Comparative Function and Biochemistry
I. Introduction
II. General Design of Surface Lipids
III. Composition and Structure of Integumental Lipids
IV. Synthesis and Transport of Integumental Lipids
V. Water Barrier Function: Working Models
References
Epidermal Vitamin D Metabolism, Function, and Regulation
I. Introduction
II. Historical Perspective
III. Chemistry of Vitamin D
IV. Role of Vitamin D in Calcium Homeostasis
V. Other Biological Actions of 1,25-(OH)2D3
VI. Mechanism of Action of 1,25-(OH)2D3
VII. Cutaneous Production of Vitamin D
VIII. Production of 1,25-(OH)2D3 and Its Regulation
IX. Production of 1,25-(OH)2D3 by Epidermal Cells in Culture
X. Effects of 1,25-(OH)2D3 on Growth and Differentiation of Keratinocytes
XI. Mechanism of Action of 1,25-(OH)2D3 in the Regulation of Epidermal Differentiation
XII. Effect of 1,25-(OH)2D3 on Other Types of Skin Cells
XIII. Concluding Remarks
References
Index
Contents of Previous Volumes
Product details
- No. of pages: 366
- Language: English
- Copyright: © Academic Press 1991
- Published: November 14, 1991
- Imprint: Academic Press
- eBook ISBN: 9781483215457