Advances in Immunology - 1st Edition - ISBN: 9780128002674, 9780128003640

Advances in Immunology, Volume 122

1st Edition

Editors: Frederick Alt
Hardcover ISBN: 9780128002674
eBook ISBN: 9780128003640
Imprint: Academic Press
Published Date: 14th January 2014
Page Count: 310
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Table of Contents

Contributors
Chapter One: Regulation of Immunoglobulin Class-Switch Recombination
Abstract

1 Overview of Genomic Alterations in B Cells

2 Initiation of CSR: S Regions and Germline Transcription

3 Induction of DNA Lesions in CSR: Essential Requirement of AID

4 Processing of Deaminated DNA: Requirements for BER and MMR Proteins

5 Completion of CSR: Synapsis and End-Joining

6 AID Phosphorylation at Serine-38 and a Role Beyond DNA Deamination

7 Multifaceted Regulation of AID Expression and Activity

8 Targeting of AID to the Ig Loci

9 AID Activity Beyond the Ig Loci

10 Perspectives

Acknowledgments

Chapter Two: Two Forms of Adaptive Immunity in Vertebrates
Abstract

1 Introduction

2 Discovery of VLR

3 Structure of VLR Proteins and Genes

4 Functions of VLR and Lymphocyte Lineages

5 Interplay of VLRB and the Complement System

6 Similarities and Differences in the Two Forms of Adaptive Immunity

7 Evolution of Antigen Receptors

8 Concluding Remarks

Acknowledgments

Chapter Three: Recognition of Tumors by the Innate Immune System and Natural Killer Cells
Abstract

1 Introduction

2 Innate Cells and Effector Molecules in Tumor Surveillance

3 Germline-Encoded Receptors Implicated in Tumor Surveillance

4 The Immunogenicity of Cancer: How Alterations Common to Cancer Can Result in Detection by Innate Immune Cells

5 Interplay Between Tumors and Innate Lymphocytes

6 Concluding Remarks

Acknowledgments

Chapter Four: Signaling Circuits in Early B-Cell Development
Abstract

1 Introduction

2 Moving from the pro-B to the pre-B Stage

3 The Interleukin 7 Receptor

4 The preBCR and Its Autonomous Signaling

5 Lessons from Transgenic and Knockout Mouse Studies

6 Signaling Pathways Controlling pre-B-Cell Expansion

7 The Switch from Proliferation to Differentiation

8 pre-B Cells and Tumors

9 Perspectives

Acknowledgments

Chapter Five: Interleukin 10 Receptor Signaling
Abstract

1 Introduction

2 IL10 and IL10 Receptor Expression and Regulation

3 Down-stream Signaling Through the IL10 Receptor

4 Regulation of Intestinal Immune Responses by IL10 in Murine Models

5 Regulation of Mucosal Homeostasis by IL10 Receptor Signaling in Mice

6 IL10-Dependent Signaling Shapes the Intestinal Microbiome

7 Impact of IL10 and IL10R Signaling Defects in Humans

8 Conclusions

Acknowledgments

Chapter Six: Development of Mast Cells and Importance of Their Tryptase and Chymase Serine Proteases in Inflammation and Wound Healing
Abstract

1 Introduction

2 Development of MCs

3 Secretory Granule Proteases of Human and Mouse MCs

4 MC Involvement in Wound Healing

5 Conclusions and Therapeutic Directions

Acknowledgments

Chapter Seven: Why Does Somatic Hypermutation by AID Require Transcription of Its Target Genes?
Abstract

1 The Basic Process of Somatic Hypermutation Before AID

2 History and Structure of AID

3 Control of Expression and Function of AID

4 Is RNA an AID Target?

5 Properties of AID Target Genes

6 SHM of Non-Ig Genes

7 SHM Versus CSR

8 A Revised Model for AID Function in SHM

9 Concluding Remarks

Acknowledgments

Index
Contents of Recent Volumes


Description

Contributors
Chapter One: Regulation of Immunoglobulin Class-Switch Recombination
Abstract

1 Overview of Genomic Alterations in B Cells

2 Initiation of CSR: S Regions and Germline Transcription

3 Induction of DNA Lesions in CSR: Essential Requirement of AID

4 Processing of Deaminated DNA: Requirements for BER and MMR Proteins

5 Completion of CSR: Synapsis and End-Joining

6 AID Phosphorylation at Serine-38 and a Role Beyond DNA Deamination

7 Multifaceted Regulation of AID Expression and Activity

8 Targeting of AID to the Ig Loci

9 AID Activity Beyond the Ig Loci

10 Perspectives

Acknowledgments

Chapter Two: Two Forms of Adaptive Immunity in Vertebrates
Abstract

1 Introduction

2 Discovery of VLR

3 Structure of VLR Proteins and Genes

4 Functions of VLR and Lymphocyte Lineages

5 Interplay of VLRB and the Complement System

6 Similarities and Differences in the Two Forms of Adaptive Immunity

7 Evolution of Antigen Receptors

8 Concluding Remarks

Acknowledgments

Chapter Three: Recognition of Tumors by the Innate Immune System and Natural Killer Cells
Abstract

1 Introduction

2 Innate Cells and Effector Molecules in Tumor Surveillance

3 Germline-Encoded Receptors Implicated in Tumor Surveillance

4 The Immunogenicity of Cancer: How Alterations Common to Cancer Can Result in Detection by Innate Immune Cells

5 Interplay Between Tumors and Innate Lymphocytes

6 Concluding Remarks

Acknowledgments

Chapter Four: Signaling Circuits in Early B-Cell Development
Abstract

1 Introduction

2 Moving from the pro-B to the pre-B Stage

3 The Interleukin 7 Receptor

4 The preBCR and Its Autonomous Signaling

5 Lessons from Transgenic and Knockout Mouse Studies

6 Signaling Pathways Controlling pre-B-Cell Expansion

7 The Switch from Proliferation to Differentiation

8 pre-B Cells and Tumors

9 Perspectives

Acknowledgments

Chapter Five: Interleukin 10 Receptor Signaling
Abstract

1 Introduction

2 IL10 and IL10 Receptor Expression and Regulation

3 Down-stream Signaling Through the IL10 Receptor

4 Regulation of Intestinal Immune Responses by IL10 in Murine Models

5 Regulation of Mucosal Homeostasis by IL10 Receptor Signaling in Mice

6 IL10-Dependent Signaling Shapes the Intestinal Microbiome

7 Impact of IL10 and IL10R Signaling Defects in Humans

8 Conclusions

Acknowledgments

Chapter Six: Development of Mast Cells and Importance of Their Tryptase and Chymase Serine Proteases in Inflammation and Wound Healing
Abstract

1 Introduction

2 Development of MCs

3 Secretory Granule Proteases of Human and Mouse MCs

4 MC Involvement in Wound Healing

5 Conclusions and Therapeutic Directions

Acknowledgments

Chapter Seven: Why Does Somatic Hypermutation by AID Require Transcription of Its Target Genes?
Abstract

1 The Basic Process of Somatic Hypermutation Before AID

2 History and Structure of AID

3 Control of Expression and Function of AID

4 Is RNA an AID Target?

5 Properties of AID Target Genes

6 SHM of Non-Ig Genes

7 SHM Versus CSR

8 A Revised Model for AID Function in SHM

9 Concluding Remarks

Acknowledgments

Index
Contents of Recent Volumes

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Immunologists and infectious disease specialists, cell biologists and hematologists


Details

No. of pages:
310
Language:
English
Copyright:
© Academic Press 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780128003640
Hardcover ISBN:
9780128002674

Reviews

"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods


About the Editors

Frederick Alt Editor

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA