Advances in Immunology - 1st Edition - ISBN: 9780124105249, 9780124105454

Advances in Immunology, Volume 117

1st Edition

Editors: Frederick Alt
eBook ISBN: 9780124105454
Hardcover ISBN: 9780124105249
Imprint: Academic Press
Published Date: 9th May 2013
Page Count: 160
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Table of Contents

Series Page


Chapter One. Mechanisms of Epigenetic Regulation of Leukemia Onset and Progression

1 Introduction

2 Aberrant DNA Methylation in Leukemia

3 Disruption of Histone-Modifying Complexes Polycomb and MLL in Leukemia

4 Other Epigenetic Writers, Erasers, and Readers

5 Novel Aspects and Technologies in Epigenetics: Implications for Leukemia

Chapter Two. Translocations in Normal B Cells and Cancers: Insights from New Technical Approaches

1 Mechanistic Elements that Generate Chromosomal Translocations

2 Novel High-Throughput Methods to Study Chromosomal Translocations

3 New Findings on Translocation Formation Obtained by HTGTS and TC-Seq

4 Landscape of Translocations in Cancers

5 Perspectives

Chapter Three. The Intestinal Microbiota in Chronic Liver Disease

1 Introduction

2 Role of the Intestinal Microbiota on Chronic Liver Diseases

3 Role of the Interactions Between the Innate Immune System and the Intestinal Microbiota on Chronic Liver Diseases

4 Probiotics and their Potential Role in Liver Disease Therapy

5 Conclusions

Chapter Four. Intracellular Pathogen Detection by RIG-I-Like Receptors

1 General Principles of the Antiviral Innate Immune Response

2 RLRs are RNA Sensors

3 RIG-I Activation and Receptor Proximal Signal Propagation

4 Regulatory Mechanisms of RIG-I Signaling

5 Conclusions and Future Directions


Contents of Recent Volumes


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Immunologists and infectious disease specialists, cell biologists and hematologists


No. of pages:
© Academic Press 2013
Academic Press
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"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

Ratings and Reviews

About the Editors

Frederick Alt Editor

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA