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Advances in Immunology - 1st Edition - ISBN: 9780120224784, 9780080493633

Advances in Immunology, Volume 78

1st Edition

Serial Volume Editor: Frank Dixon
eBook ISBN: 9780080493633
Hardcover ISBN: 9780120224784
Imprint: Academic Press
Published Date: 15th June 2001
Page Count: 340
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Table of Contents

  • Toll-like Receptors and Innate Immunity
    • I Introduction
    • II Toll Receptors in Drosophila Development
    • III Toll Receptors in Innate Immunity of Drosophila
    • IV Mammalian IL-1R-Signaling Pathway: Its Similarity with Drosophila Toll Signaling
    • V Discovery of Toll-like Receptors in Mammals
    • VI LPS and Its Binding Molecules
    • VII Intracellular Events Following LPS Stimulation
    • VIII Nuclear Factors Activated by LPS
    • IX TLR4 and LPS Signaling
    • X Role of MyD88 in LPS Signaling
    • XI MyD88-Dependent and -Independent Pathways in LPS Signaling
    • XII LPS Internalization
    • XIII Species Differences in LPS Response
    • XIV Taxol and LPS
    • XV LPS Tolerance
    • XVI TLR2 and LPS Signaling
    • XVII Recognition of Microbial Cell Wall Components by TLRs
    • XVIII Toll-like Receptors and Host Resistance to Microbial Infection
    • XIX Conclusion
  • Chemokines in Immunity
    • Abstract
    • I Introduction
    • II Chemokine Superfamily
    • III Migratory Properties of Lymphocytes and Dendritic Cells
    • IV Primary Lymphoid Organs and Chemokines
    • V Secondary Lymphoid Organs and Chemokines
    • VI Effector/Memory Cells and Chemokines
    • VII Dendritic Cells and Chemokines
    • VIII Concluding Remarks
  • Attractions and Migrations of Lymphoid Cells in the Organization of Humoral Immune Responses
    • I Introduction
    • II Structures of Chemokines and Their Receptors
    • III Rules to Understand Receptor–Ligand Interaction and Migration in vivo
    • IV The Generation of Cells Involved in the Humoral Defense against Foreign Invaders
    • V The Population of Secondary Lymphoid Organs by Lymphoid Cells
    • VI Compartmental Homing within Secondary Lymphoid Organs
    • VII Cellular Traffic Leading to a Humoral Immune Response: Finding the Right Partner
    • VIII Migration of Effector and Memory T and B Cells
    • IX Possible Clinical Relevance of the ABCD Chemokines
    • X Future Perspectives
  • Factors and Forces Controlling V(D)J Recombination
    • I Introduction
    • II Basic Features of V(D)J Recombination
    • III Forces Controlling Chromatin Structure and Accessibility
    • IV Cis-Acting Elements and the Assembly of Antigen Receptor Loci
    • V The Factors
    • VI The Two Substrate Problem
    • VII Models
    • Note Added in Proof
  • T Cell Effector Subsets: Extending the Th1/Th2 Paradigm
    • I Introduction
    • II T Cell Effector Subsets
    • III What Determines Effector T Cell Differentiation?
    • IV Transcription Factors for T Cell Differentiation
    • V The Link between Chemokine Receptors and T Cell Effector Function
    • VI Cell Surface and Costimulatory Molecules That Distinguish T Cell Effector Functions
    • VII Microarrays for the Identification of T Cell Subset Expressed Genes
    • VIII Conclusions
  • MHC-Restricted T Cell Responses against Posttranslationally Modified Peptide Antigens
    • I Introduction
    • II Posttranslational Modifications of Proteins
    • III Posttranslational Modifications and Antigen Processing
    • IV Posttranslational Modifications and MHC Binding
    • V Posttranslational Modifications and T Cell Recognition
    • VI Post translationally Modified Peptide Antigens: Are They Immunologically Relevant?
  • Gastrointestinal Eosinophils in Health and Disease
    • I Introduction
    • II Gastrointestinal Eosinophils in Healthy States
    • III Gastrointestinal Eosinophils in Disease States
    • IV Experimental Dissection of Eosinophilic Gastrointestinal Inflammation
    • V Function of Eosinophils
    • VI Summary and Concluding Remarks
  • Index
  • Contents of Recent Volumes


Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that constitue immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Immunology is vital to the understanding of infection and disease. Application of this information may lead to resistance and cures for higher animals and humans.


Graduate students, researchers, and clinicians in immunology and cell and molecular biology.


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© Academic Press 2001
15th June 2001
Academic Press
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Ratings and Reviews

About the Serial Volume Editor

Frank Dixon

Affiliations and Expertise

The Scripps Research Institute, La Jolla, California, U.S.A.