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Advances in Immunology
1st Edition, Volume 78 - June 15, 2001
Editor: Frank J. Dixon
Language: English
Hardback ISBN:9780120224784
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eBook ISBN:9780080493633
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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that constitue immunology, includ…Read more
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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that constitue immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.Immunology is vital to the understanding of infection and disease. Application of this information may lead to resistance and cures for higher animals and humans.
Graduate students, researchers, and clinicians in immunology and cell and molecular biology.
Toll-like Receptors and Innate Immunity
I Introduction
II Toll Receptors in Drosophila Development
III Toll Receptors in Innate Immunity of Drosophila
IV Mammalian IL-1R-Signaling Pathway: Its Similarity with Drosophila Toll Signaling
V Discovery of Toll-like Receptors in Mammals
VI LPS and Its Binding Molecules
VII Intracellular Events Following LPS Stimulation
VIII Nuclear Factors Activated by LPS
IX TLR4 and LPS Signaling
X Role of MyD88 in LPS Signaling
XI MyD88-Dependent and -Independent Pathways in LPS Signaling
XII LPS Internalization
XIII Species Differences in LPS Response
XIV Taxol and LPS
XV LPS Tolerance
XVI TLR2 and LPS Signaling
XVII Recognition of Microbial Cell Wall Components by TLRs
XVIII Toll-like Receptors and Host Resistance to Microbial Infection
XIX Conclusion
ACKNOWLEDGMENTS
Chemokines in Immunity
Abstract
I Introduction
II Chemokine Superfamily
III Migratory Properties of Lymphocytes and Dendritic Cells
IV Primary Lymphoid Organs and Chemokines
V Secondary Lymphoid Organs and Chemokines
VI Effector/Memory Cells and Chemokines
VII Dendritic Cells and Chemokines
VIII Concluding Remarks
ACKNOWLEDGMENT
Attractions and Migrations of Lymphoid Cells in the Organization of Humoral Immune Responses
I Introduction
II Structures of Chemokines and Their Receptors
III Rules to Understand Receptor–Ligand Interaction and Migration in vivo
IV The Generation of Cells Involved in the Humoral Defense against Foreign Invaders
V The Population of Secondary Lymphoid Organs by Lymphoid Cells
VI Compartmental Homing within Secondary Lymphoid Organs
VII Cellular Traffic Leading to a Humoral Immune Response: Finding the Right Partner
VIII Migration of Effector and Memory T and B Cells
IX Possible Clinical Relevance of the ABCD Chemokines
X Future Perspectives
ACKNOWLEDGMENT
Factors and Forces Controlling V(D)J Recombination
I Introduction
II Basic Features of V(D)J Recombination
III Forces Controlling Chromatin Structure and Accessibility
IV Cis-Acting Elements and the Assembly of Antigen Receptor Loci
V The Factors
VI The Two Substrate Problem
VII Models
Note Added in Proof
ACKNOWLEDGMENTS
T Cell Effector Subsets: Extending the Th1/Th2 Paradigm
I Introduction
II T Cell Effector Subsets
III What Determines Effector T Cell Differentiation?
IV Transcription Factors for T Cell Differentiation
V The Link between Chemokine Receptors and T Cell Effector Function
VI Cell Surface and Costimulatory Molecules That Distinguish T Cell Effector Functions
VII Microarrays for the Identification of T Cell Subset Expressed Genes
VIII Conclusions
ACKNOWLEDGMENTS
MHC-Restricted T Cell Responses against Posttranslationally Modified Peptide Antigens
I Introduction
II Posttranslational Modifications of Proteins
III Posttranslational Modifications and Antigen Processing
IV Posttranslational Modifications and MHC Binding
V Posttranslational Modifications and T Cell Recognition
VI Post translationally Modified Peptide Antigens: Are They Immunologically Relevant?
Gastrointestinal Eosinophils in Health and Disease
I Introduction
II Gastrointestinal Eosinophils in Healthy States
III Gastrointestinal Eosinophils in Disease States
IV Experimental Dissection of Eosinophilic Gastrointestinal Inflammation
V Function of Eosinophils
VI Summary and Concluding Remarks
ACKNOWLEDGMENTS
Index
Contents of Recent Volumes
No. of pages: 340
Language: English
Edition: 1
Volume: 78
Published: June 15, 2001
Imprint: Academic Press
Hardback ISBN: 9780120224784
eBook ISBN: 9780080493633
FD
Frank J. Dixon
Affiliations and expertise
The Scripps Research Institute, La Jolla, California, U.S.A.