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Chapter One: Macrophages and Mitochondria: A Critical Interplay Between Metabolism, Signaling, and the Functional Activity
- 1 Introduction
- 2 Mitochondrial Metabolism Governs Macrophage Activation State
- 3 Mitochondrial ROS in Innate Immune Responses
- 4 Mitochondrial-Mediated Antiviral Immunity
- 5 Inflammasome Activation and Mitochondria
- 6 Concluding Remarks
Chapter Two: Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination
- 1 Antibody Diversification During the Humoral Response
- 2 Molecular Mechanisms of SHM and CSR
- 3 DNA Deamination at the Igs
- 4 AID Initiates a DNA Repair Cascade
- 5 Postdeamination Roles of AID?
- 6 Perspectives
Chapter Three: Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5
- 1 Background
- 2 Lessons From CIITA
- 3 NLRC5 and Its Role in Regulating MHC Class I Levels
- 4 NLRC5 and Its Emerging Roles in Health and Disease
- 5 Concluding Remarks
Chapter Four: Nucleic Acid Immunity
- 1 Introduction
- 2 Principles of Nucleic Acid Immunity in Different Species
- 3 Historic Overview of Different Fields Merging Into Nucleic Acid Immunity
- 4 Functional Components of Nucleic Acid Immunity
- 5 Innate and Adaptive Components in Nucleic Acid Immunity
- 6 Innate and Adaptive Nucleic Acid Immunity in Prokaryotes
- 7 Receptors and Nucleases Not Involving Classical Immune Functions
- 8 RNA Interference
- 9 Immune-Sensing Receptors
- 10 Conclusions
Chapter Five: About Training and Memory: NK-Cell Adaptation to Viral Infections
- 1 Introduction
- 2 NK-Cell Adaptations to Viral Infections
- 3 Functional Imprinting of Adaptive NK Cells
- 4 Epigenetic Remodeling as Hallmark of Immune Training and Memory
- 5 Training and Cross-Reactive Memory: Consequences for Heterologous Immunity
- 6 Outlook and Outstanding Questions
Advances in Immunology, Volume 133, the latest release in this long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.
- Contains contributions from leading authorities
- Informs and updates on all the latest developments in the field of immunology
- Addresses molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities
Immunologists and infectious disease specialists, cell biologists and hematologists
- No. of pages:
- © Academic Press 2017
- 20th February 2017
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Harvard Medical School, Boston, MA, USA
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