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Advances in Immunology - 1st Edition - ISBN: 9780128124079, 9780128124086

Advances in Immunology, Volume 134

1st Edition

Serial Editor: Frederick Alt
Hardcover ISBN: 9780128124079
eBook ISBN: 9780128124086
Imprint: Academic Press
Published Date: 22nd April 2017
Page Count: 360
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Table of Contents

Chapter One: γδ T Cells and B Cells
W.K. Born, Y. Huang, R.L Reinhardt, H. Huang, D. Sun and R.L. O’Brien

  • Abstract
  • 1 Tripartite Adaptive Immune System
  • 2 γδ T Cells
  • 3 Interaction Between γδ T Cells and B Cells

Chapter Two: A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes
V.Y. Lim, S. Zehentmeier, C. Fistonich and J.P. Pereira

  • Abstract
  • 1 Introduction
  • 2 HSC Niches
  • 3 Hematopoietic Multipotent Progenitor Niches
  • 4 Bone Marrow Niches Controlling Lymphoid Lineage Commitment
  • 5 Transition From ProB to PreB to Immature B Cell
  • 6 Egress From Bone Marrow
  • 7 Transitional Differentiation in Periphery
  • 8 Concluding Remarks
  • Acknowledgments

Chapter Three: Tissue-Specific Diversity and Functions of Conventional Dendritic Cells
D. Pakalniškytė and B.U. Schraml

  • Abstract
  • 1 Dendritic Cell Development
  • 2 cDCs in Lymphoid Organs
  • 3 cDCs in Nonlymphoid Organs
  • 4 Concluding Remarks
  • Acknowledgments

Chapter Four: Regulation of Innate and Adaptive Immunity by TGFβ

  • 1 Introduction
  • 2 TGFβ and the Adaptive Immune System
  • 3 TGFβ and the Innate Immune System
  • 4 Concluding Remarks
  • Acknowledgments

Chapter Five: Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem
L. Verkoczy

  • Abstract
  • 1 Overview of the Current State of HIV Vaccine Research
  • 2 Characteristics of bnAbs Isolated During Infection and Their Env Targets: Clues for Vaccine Design
  • 3 Current Gaps in HIV Vaccinology
  • 4 Human Ig KI Models in Elucidating bnAb Tolerance Controls and Testing Ways to Overcome Them
  • 5 bnAb KI Models for Testing New HIV Vaccine Strategies
  • 6 Ig KI-Related Methodological Advances Relevant for Studying bnAb Development
  • 7 Perspectives
  • Acknowledgments


Advances in Immunology, Volume 134, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Topics covered in this new volume include γδ T Cells and B Cells, A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes. Tissue Specific Regulation of Dendritic Cell Development and Function, and the Regulation of Innate and Adaptive Immunity by Transforming Growth Factor Beta (TGFβ). Articles in this long running series address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities.

Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Contains contributions from leading authorities
  • Informs and updates on all the latest developments in the field of immunology


Immunologists and infectious disease specialists, cell biologists and hematologists


No. of pages:
© Academic Press 2017
22nd April 2017
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Editor

Frederick Alt

Frederick Alt

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Affiliations and Expertise

Harvard Medical School, Boston, MA, USA