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- Chapter One: Context- and Tissue-Specific Regulation of Immunity and Tolerance by Regulatory T Cells
- 1 Introduction
- 2 Origins of Treg Cells: “The Third Function of the Thymus (Seddon & Mason, 2000)”
- 3 Suppressive Properties of Treg Cells
- 4 Murine Tissue-Specific Treg Cells
- 5 Human Tissue-Resident Treg Cells
- 6 Conclusions
- Chapter Two: Endogenous Retroelements and the Host Innate Immune Sensors
- 1 Introduction
- 2 Toll-Like Receptors
- 3 RIG-I and MDA5
- 4 Protein Kinase R
- 5 Inflammasome
- 6 Conclusion and Perspectives
- Chapter Three: B-Lymphopoiesis in Fetal Liver, Guided by Chemokines
- 1 Introduction
- 2 Lineage Choice Between Myeloid and Lymphoid Development
- 3 Cytokine Receptor Expressions on Early Progenitors in Fetal Liver
- 4 Changes of Transcription Factor Expressions and of Hematopoietic Differentiation Capacities During Myeloid/Lymphoid Progenitor Development
- 5 B-Cell Development from Early Fetal Liver Progenitors
- 6 Nonhematopoietic Mesenchymal Stromal Cells, but not Endothelial Cells, Produce Myeloid-Inducing CSF-1 and Lymphoid-Inducing IL7
- 7 Selective Chemokines Produced by Endothelium or Mesenchyme Guide Migration of Single Progenitors Expressing Several Chemokine Receptors from Blood to Hepatic Mesenchyme
- 8 Outlook
- Chapter Four: The Roles of the Secreted Phospholipase A2 Gene Family in Immunology
- 1 General Aspects of sPLA2s
- 2 Potential Roles of sPLA2s: Lessons from sPLA2 Transgenic Mice
- 3 Group IIA sPLA2 (PLA2G2A)
- 4 Group IID sPLA2 (PLA2G2D)
- 5 Group IIF sPLA2 (PLA2G2F)
- 6 Group III sPLA2 (PLA2G3)
- 7 Group V sPLA2 (PLA2G5)
- 8 Group X sPLA2 (PLA2G10)
- 9 Other sPLA2s and sPLA2 Receptor (PLA2R1)
- 10 Perspectives
- Chapter Five: Pleiotropic Roles of Type 1 Interferons in Antiviral Immune Responses
- 1 Type 1 Interferon Signaling During Acute Viral Infection
- 2 Type I Interferon Signaling and Persistent/Chronic Viral Infection
- 3 Perspective
- Contents of Recent Volumes
Advances in Immunology, a long-established and highly respected publication, presents current developments and comprehensive reviews on immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.
- Contains contributions from leading authorities
- Informs and updates on all the latest developments in the field of immunology
Immunologists and infectious disease specialists, cell biologists and hematologists
- No. of pages:
- © Academic Press 2016
- 19th October 2016
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Harvard Medical School, Boston, MA, USA
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