Advances in Immunology - 1st Edition - ISBN: 9780128001004, 9780128002575

Advances in Immunology, Volume 121

1st Edition

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Editors: Frederick Alt
Hardcover ISBN: 9780128001004
eBook ISBN: 9780128002575
Imprint: Academic Press
Published Date: 14th January 2014
Page Count: 276
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Table of Contents

  • Contributors
  • Chapter One. Multifarious Determinants of Cytokine Receptor Signaling Specificity
    • Abstract
    • 1 Introduction
    • 2 Ligand–Receptor Complex Formation: Geometry and Affinity
    • 3 Receptor Dynamics and Endosomal Trafficking
    • 4 Intracellular Protein Levels and Signaling Activation
    • 5 Tuning Cytokine Signaling via Protein Engineering
    • 6 Perspectives
    • Acknowledgments
    • References
  • Chapter Two. Pathogenic Mechanisms of Bradykinin Mediated Diseases: Dysregulation of an Innate Inflammatory Pathway
    • Abstract
    • 1 Introduction
    • 2 Contact Activation: Factor XII-Dependent Initiation of Bradykinin Formation
    • 3 Assembly on Cell Surfaces: Binding of HK to HUVEC
    • 4 Binding of Factor XII to HUVEC
    • 5 Interaction of gC1qR, Cytokeratin 1, and u-PAR Within HUVEC Cell Membranes
    • 6 Binding to Other Cells
    • 7 Activation of the Kinin Cascade: The Role of Endothelial Cells
    • 8 Inhibition of Contact Activation
    • 9 Inactivation of Bradykinin
    • 10 Further Considerations of the Initiating Site for Bradykinin Formation: Evidence That the PK–HK Complex has Enzymatic Activity
    • 11 Hereditary Angioedema (Types I and II = C1 Inhibitor Deficiency)
    • 12 Bradykinin Formation When C1 INH is Absent/Dysfunctional
    • 13 Type III HAE
    • 14 New Modalities for Treatment of HAE
    • 15 Proteoglycan-Dependent Activation of Factor XII: Theoretical Mechanisms for Bradykinin Production in “Allergic” Diseases; Particularly Anaphylaxis, Chronic Spontaneous Urticaria, and Rhinitis/Asthma
    • 16 Activation of Factor XII by Aggregated Proteins
    • References
  • Chapter Three. The Role of Short-Chain Fatty Acids in Health and Disease
    • Abstract
    • 1 Introduction
    • 2 SCFA Sensing and Signal Transduction
    • 3 Varied Functions of SCFAs
    • 4 Integrative View of the Gut Microbiota, SCFAs, and Disease
    • 5 Perspective
    • References
  • Chapter Four. Combined Immunodeficiencies with Nonfunctional T Lymphocytes
    • Abstract
    • 1 Introduction
    • 2 Immunodeficiency Phenotypes due to Hypomorphic Mutations in SCID-Associated Genes
    • 3 Other Combined Immunodeficiencies with Dysfunctional T Cells
    • 4 Conclusions
    • References
  • Chapter Five. The CD200–CD200R1 Inhibitory Signaling Pathway: Immune Regulation and Host–Pathogen Interactions
    • Abstract
    • 1 Inhibitory Receptors
    • 2 The Inhibitory Receptor CD200R1
    • 3 Perspective
    • Acknowledgments
    • References
  • Chapter Six. Immunopathogenesis of Neuromyelitis Optica
    • Abstract
    • 1 Introduction
    • 2 Aquaporin-4 Antibodies
    • 3 Innate Immunity
    • 4 Adaptive Immunity
    • 5 Summary
    • Acknowledgments
    • References
  • Index
  • Contents of Recent Volumes


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Informs and updates on all the latest developments in the field
  • Contributions from leading authorities and industry experts


Immunologists and infectious disease specialists, cell biologists and hematologists


No. of pages:
© Academic Press 2014
14th January 2014
Academic Press
Hardcover ISBN:
eBook ISBN:


"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

Ratings and Reviews

About the Editors

Frederick Alt

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA