Advances in Immunology

Advances in Immunology

1st Edition - April 20, 2013

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  • Editor: Frederick Alt
  • eBook ISBN: 9780124105454
  • Hardcover ISBN: 9780124105249

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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Immunologists and infectious disease specialists, cell biologists and hematologists

Table of Contents

  • Series Page


    Chapter One. Mechanisms of Epigenetic Regulation of Leukemia Onset and Progression

    1 Introduction

    2 Aberrant DNA Methylation in Leukemia

    3 Disruption of Histone-Modifying Complexes Polycomb and MLL in Leukemia

    4 Other Epigenetic Writers, Erasers, and Readers

    5 Novel Aspects and Technologies in Epigenetics: Implications for Leukemia

    Chapter Two. Translocations in Normal B Cells and Cancers: Insights from New Technical Approaches

    1 Mechanistic Elements that Generate Chromosomal Translocations

    2 Novel High-Throughput Methods to Study Chromosomal Translocations

    3 New Findings on Translocation Formation Obtained by HTGTS and TC-Seq

    4 Landscape of Translocations in Cancers

    5 Perspectives

    Chapter Three. The Intestinal Microbiota in Chronic Liver Disease

    1 Introduction

    2 Role of the Intestinal Microbiota on Chronic Liver Diseases

    3 Role of the Interactions Between the Innate Immune System and the Intestinal Microbiota on Chronic Liver Diseases

    4 Probiotics and their Potential Role in Liver Disease Therapy

    5 Conclusions

    Chapter Four. Intracellular Pathogen Detection by RIG-I-Like Receptors

    1 General Principles of the Antiviral Innate Immune Response

    2 RLRs are RNA Sensors

    3 RIG-I Activation and Receptor Proximal Signal Propagation

    4 Regulatory Mechanisms of RIG-I Signaling

    5 Conclusions and Future Directions


    Contents of Recent Volumes

Product details

  • No. of pages: 160
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: April 20, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780124105454
  • Hardcover ISBN: 9780124105249

About the Editor

Frederick Alt

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Affiliations and Expertise

Investigator and Director of the Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA

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