Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Immunologists and infectious disease specialists, cell biologists and hematologists

Table of Contents

Series Page


Chapter One. Fate Determination of Mature Autoreactive B Cells

1 Introduction

2 Formation of the Naive B Cell Repertoire

3 B Cell Activation

4 The Cellular Composition of GC

5 The GC Response

6 Regulating Autoreactivity Within the GC

7 Cellular Mediators of GC Selection

8 Regulation of Plasma Cells

9 Conclusion


Chapter Two. Epigenetic Control of Cytokine Gene Expression: Regulation of the TNF/LT Locus and T Helper Cell Differentiation

1 The Components of Epigenetic Transcriptional Regulation

2 Cytokine Gene Regulation

3 Perspectives and Future Directions


Chapter Three. Autoimmunity in Rheumatoid Arthritis: Citrulline Immunity and Beyond

1 Introduction

2 Present State of the Art Concerning Genes, Environment, and Anticitrulline Immunity in RA

3 Unresolved Issues Concerning the Specificity and Genetic Basis of Autoimmune Reactions in RA: Focus on the Heterogeneity of the RA Syndrome

4 Unresolved Issues Concerning the Triggering of Various Autoimmune Reactions in RA: Focus on Events Outside the Joints

5 Unresolved Issues Concerning the Contributions of Various Autoimmune Reactions to Symptoms of RA: Focus on Events in Joints and in Sites of Extra-Articular Manifestations of RA

6 Conclusions Concerning Research Strategies and Efforts to Turn the Emerging Insights of Adaptive Immunity in RA into Personalized Prevention and Therapy



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© 2013
Academic Press
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About the editor

Frederick Alt

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA


"The series which all immunologists need." --The Pharmaceutical Journal

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