Advances in Immunology - 1st Edition - ISBN: 9780124077089, 9780124077362

Advances in Immunology, Volume 118

1st Edition

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Editors: Frederick Alt
Hardcover ISBN: 9780124077089
eBook ISBN: 9780124077362
Imprint: Academic Press
Published Date: 3rd June 2013
Page Count: 198
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Table of Contents

Series Page


Chapter One. Fate Determination of Mature Autoreactive B Cells

1 Introduction

2 Formation of the Naive B Cell Repertoire

3 B Cell Activation

4 The Cellular Composition of GC

5 The GC Response

6 Regulating Autoreactivity Within the GC

7 Cellular Mediators of GC Selection

8 Regulation of Plasma Cells

9 Conclusion


Chapter Two. Epigenetic Control of Cytokine Gene Expression: Regulation of the TNF/LT Locus and T Helper Cell Differentiation

1 The Components of Epigenetic Transcriptional Regulation

2 Cytokine Gene Regulation

3 Perspectives and Future Directions


Chapter Three. Autoimmunity in Rheumatoid Arthritis: Citrulline Immunity and Beyond

1 Introduction

2 Present State of the Art Concerning Genes, Environment, and Anticitrulline Immunity in RA

3 Unresolved Issues Concerning the Specificity and Genetic Basis of Autoimmune Reactions in RA: Focus on the Heterogeneity of the RA Syndrome

4 Unresolved Issues Concerning the Triggering of Various Autoimmune Reactions in RA: Focus on Events Outside the Joints

5 Unresolved Issues Concerning the Contributions of Various Autoimmune Reactions to Symptoms of RA: Focus on Events in Joints and in Sites of Extra-Articular Manifestations of RA

6 Conclusions Concerning Research Strategies and Efforts to Turn the Emerging Insights of Adaptive Immunity in RA into Personalized Prevention and Therapy



Contents of Recent Volumes


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Immunologists and infectious disease specialists, cell biologists and hematologists


No. of pages:
© Academic Press 2013
3rd June 2013
Academic Press
Hardcover ISBN:
eBook ISBN:


"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

Ratings and Reviews

About the Editors

Frederick Alt

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA