Advances in Immunology - 1st Edition - ISBN: 9780124077072, 9780124077355

Advances in Immunology, Volume 119

1st Edition

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Editors: Frederick Alt
Hardcover ISBN: 9780124077072
eBook ISBN: 9780124077355
Imprint: Academic Press
Published Date: 5th August 2013
Page Count: 186
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Table of Contents

Series Page


Chapter One. The Interdisciplinary Science of T-cell Recognition

1 Introduction

2 The First Level of Complexity: The Kinetics and Structural Basis of TCR–pMHC Engagement

3 The Second Level of Complexity: The TCR–CD3 Complex and Approaches to Answers of How It Works

4 The Third Level of Complexity: Antigen Recognition and the Immunological Synapse

5 Perspective



Chapter Two. Residual Immune Dysregulation Syndrome in Treated HIV infection

1 The Role of Activation and Inflammation in the Natural History of Infection

2 Inflammatory and Coagulation Indices Predict Morbidity in Treated HIV Infection

3 Persistent CD4 + T Cell Lymphopenia Predicts Clinical Outcomes During ART

4 Immune Activation/Inflammation Predicts Morbidity and Mortality During ART

5 Failure to Restore Circulating CD4 + T Cells in HIV Infection

6 The LN in Treated HIV Infection

7 The Gut in Treated HIV Infection

8 Other Possible Drivers of Residual Immune Dysregulation in Treated HIV Infection

9 Therapeutic Approaches

10 Summary



Chapter Three. Developmental Plasticity of Murine and Human Foxp3+ Regulatory T Cells

1 Introduction

2 Stability and Plasticity of Regulatory T Cells

3 A Transient Flexibility Model for Regulatory T Cell Plasticity

4 Differences in Foxp3/FOXP3 Between Mice and Humans

5 Significance and Future Directions



Chapter Four. Logic of the Inflammation-Associated Transcriptional Response

1 Dynamic of Inflammatory Gene Expression—Bursts and Noise

2 Control of Inflammation by RNA Elongation

3 Pharmacological Targeting of RNA Elongation by BET Antagonists

4 Targeting of Inflammation by Pathogen-Derived Chromatin Modifiers

5 Concluding Remarks


Chapter Five. Structural Basis of Signal Transduction in the TNF Receptor Superfamily

1 Introduction

2 NF-κB Activation

3 TNFR1 and Fas-Induced Apoptosis

4 TNFR1-Induced Programmed Necrosis

5 Conclusions




Contents of Recent Volumes


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Immunologists and infectious disease specialists, cell biologists and hematologists.


No. of pages:
© Academic Press 2013
5th August 2013
Academic Press
Hardcover ISBN:
eBook ISBN:


"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

Ratings and Reviews

About the Editors

Frederick Alt

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA