Advances in Immunology - 1st Edition - ISBN: 9780124077072, 9780124077355

Advances in Immunology, Volume 119

1st Edition

Editors: Frederick Alt
Hardcover ISBN: 9780124077072
eBook ISBN: 9780124077355
Imprint: Academic Press
Published Date: 5th August 2013
Page Count: 186
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Table of Contents

Series Page

Contributors

Chapter One. The Interdisciplinary Science of T-cell Recognition

1 Introduction

2 The First Level of Complexity: The Kinetics and Structural Basis of TCR–pMHC Engagement

3 The Second Level of Complexity: The TCR–CD3 Complex and Approaches to Answers of How It Works

4 The Third Level of Complexity: Antigen Recognition and the Immunological Synapse

5 Perspective

Acknowledgments

References

Chapter Two. Residual Immune Dysregulation Syndrome in Treated HIV infection

1 The Role of Activation and Inflammation in the Natural History of Infection

2 Inflammatory and Coagulation Indices Predict Morbidity in Treated HIV Infection

3 Persistent CD4 + T Cell Lymphopenia Predicts Clinical Outcomes During ART

4 Immune Activation/Inflammation Predicts Morbidity and Mortality During ART

5 Failure to Restore Circulating CD4 + T Cells in HIV Infection

6 The LN in Treated HIV Infection

7 The Gut in Treated HIV Infection

8 Other Possible Drivers of Residual Immune Dysregulation in Treated HIV Infection

9 Therapeutic Approaches

10 Summary

Acknowledgment

References

Chapter Three. Developmental Plasticity of Murine and Human Foxp3+ Regulatory T Cells

1 Introduction

2 Stability and Plasticity of Regulatory T Cells

3 A Transient Flexibility Model for Regulatory T Cell Plasticity

4 Differences in Foxp3/FOXP3 Between Mice and Humans

5 Significance and Future Directions

Acknowledgments

References

Chapter Four. Logic of the Inflammation-Associated Transcriptional Response

1 Dynamic of Inflammatory Gene Expression—Bursts and Noise

2 Control of Inflammation by RNA Elongation

3 Pharmacological Targeting of RNA Elongation by BET Antagonists

4 Targeting of Inflammation by Pathogen-Derived Chromatin Modifiers

5 Concluding Remarks

References

Chapter Five. Structural Basis of Signal Transduction in the TNF Receptor Superfamily

1 Introduction

2 NF-κB Activation

3 TNFR1 and Fas-Induced Apoptosis

4 TNFR1-Induced Programmed Necrosis

5 Conclusions

Acknowledgment

References

Index

Contents of Recent Volumes


Description

Series Page

Contributors

Chapter One. The Interdisciplinary Science of T-cell Recognition

1 Introduction

2 The First Level of Complexity: The Kinetics and Structural Basis of TCR–pMHC Engagement

3 The Second Level of Complexity: The TCR–CD3 Complex and Approaches to Answers of How It Works

4 The Third Level of Complexity: Antigen Recognition and the Immunological Synapse

5 Perspective

Acknowledgments

References

Chapter Two. Residual Immune Dysregulation Syndrome in Treated HIV infection

1 The Role of Activation and Inflammation in the Natural History of Infection

2 Inflammatory and Coagulation Indices Predict Morbidity in Treated HIV Infection

3 Persistent CD4 + T Cell Lymphopenia Predicts Clinical Outcomes During ART

4 Immune Activation/Inflammation Predicts Morbidity and Mortality During ART

5 Failure to Restore Circulating CD4 + T Cells in HIV Infection

6 The LN in Treated HIV Infection

7 The Gut in Treated HIV Infection

8 Other Possible Drivers of Residual Immune Dysregulation in Treated HIV Infection

9 Therapeutic Approaches

10 Summary

Acknowledgment

References

Chapter Three. Developmental Plasticity of Murine and Human Foxp3+ Regulatory T Cells

1 Introduction

2 Stability and Plasticity of Regulatory T Cells

3 A Transient Flexibility Model for Regulatory T Cell Plasticity

4 Differences in Foxp3/FOXP3 Between Mice and Humans

5 Significance and Future Directions

Acknowledgments

References

Chapter Four. Logic of the Inflammation-Associated Transcriptional Response

1 Dynamic of Inflammatory Gene Expression—Bursts and Noise

2 Control of Inflammation by RNA Elongation

3 Pharmacological Targeting of RNA Elongation by BET Antagonists

4 Targeting of Inflammation by Pathogen-Derived Chromatin Modifiers

5 Concluding Remarks

References

Chapter Five. Structural Basis of Signal Transduction in the TNF Receptor Superfamily

1 Introduction

2 NF-κB Activation

3 TNFR1 and Fas-Induced Apoptosis

4 TNFR1-Induced Programmed Necrosis

5 Conclusions

Acknowledgment

References

Index

Contents of Recent Volumes

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Immunologists and infectious disease specialists, cell biologists and hematologists.


Details

No. of pages:
186
Language:
English
Copyright:
© Academic Press 2013
Published:
Imprint:
Academic Press
eBook ISBN:
9780124077355
Hardcover ISBN:
9780124077072

Reviews

"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods


About the Editors

Frederick Alt Editor

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA