Advances in Immunology - 1st Edition - ISBN: 9780123743244, 9780080879017

Advances in Immunology, Volume 97

1st Edition

Editors: Frederick Alt
Hardcover ISBN: 9780123743244
eBook ISBN: 9780080879017
Imprint: Academic Press
Published Date: 11th June 2008
Page Count: 312
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Table of Contents

  • Contributors to Volume 97
    • Publisher Summary
  • T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other
    • Abstract
    • 1 Introduction
    • 2 TCR Signaling Leading to Actin Cytoskeletal Remodeling
    • 3 Cytoskeletal Control of IS Formation
    • 4 Regulation of TCR‐Mediated MTOC Polarization
    • 5 F‐Actin‐Mediated Regulation of Integrins
    • 6 Cytoskeletal Dynamics and Cell Migration
    • 7 Conclusion
  • HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases
    • Abstract
    • 1 Introduction
    • 2 Expression and Function of HLA‐DQ Transgenes in Mice
    • 3 HLA‐DQ Transgenic Mice as Models for Human Allergies
    • 4 Expression and Function of HLA‐DR Transgenic Mice
    • 5 HLA Class II Transgenic Mice Identify the Same Determinants of M. Tuberculosis‐Derived Proteins as Humans
    • 6 Collagen‐Induced Arthritis—Model for Human Rheumatoid Arthritis
    • 7 Experimental Autoimmune Encephalomyelitis: A Model for Multiple Sclerosis
    • 8 Spontaneous Models for Human Type I Diabetes
    • 9 Experimental Autoimmune Myasthenia Gravis
    • 10 HLA and Gluten Sensitivity‐Celiac Disease and Dermatitis herpetiformis
    • 11 Relapsing Polychondritis
    • 12 Spontaneous Autoimmune Myocarditis
    • 13 Experimental Autoimmune Thyroiditis (Adapted from Kong et al., 2007)
    • 14 Experimental Autoimmune Uveitis (Adapted fromPennesi et al., 2003)
    • 15 Bacterial Superantigens and Toxic Shock Syndrome
    • 16 Concluding Remarks
  • Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule
    • Abstract
    • 1 Introduction
    • 2 Zn Homeostasis, Zn Transporters, and Metallothioneins in Health and Disease
    • 3 Role of Zn in the Immune Response
    • 4 Role of Zn in Mast Cells
    • 5 Zn Signaling
    • 6 Conclusion and Future Prospects
    • Acknowledgements
  • The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses
    • Abstract
    • 1 Introduction
    • 2 Structure, Ligands, and Expression of the SLAM‐Family Receptors
    • 3 The SLAM‐Family Gene Isoforms and Polymorphisms and their Role in a Genetic Predisposition for Systemic Lupus Erythematosus
    • 4 The SLAM‐Associated Protein
    • 5 The Protective Role of SAP in X‐Linked Lympho‐Proliferative Disease
    • 6 The SAP‐Related Single SH2‐Domain Proteins EAT‐2A and EAT‐2B
    • 7 The SLAM‐Family Receptors in NK Cell Responses
    • 8 The Role of the SLAM‐Family in Lymphoid Cells
    • 9 The Role of the SLAM‐Family on Nonlymphoid Cells
    • 10 Concluding Remarks
  • Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lymphocytes
    • Abstract
    • 1 Introduction
    • 2 A Minimal Signaling Kit Couples to Proximal Transducer Enzymes
    • 3 Signal Initiation: BCR Clusters with an Open Conformation
    • 4 SLP-65: A Gateway to Intracellular Signaling Pathways
    • 5 Dynamic Regulation of the BCR-Triggered Ca2+ Response
    • 6 Mechanism and Function of BCR-Induced Ras Activation
    • 7 Concluding Remarks
  • Subject Index
    • Publisher Summary
  • Contents of Recent volumes

Description

  • Contributors to Volume 97
    • Publisher Summary
  • T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other
    • Abstract
    • 1 Introduction
    • 2 TCR Signaling Leading to Actin Cytoskeletal Remodeling
    • 3 Cytoskeletal Control of IS Formation
    • 4 Regulation of TCR‐Mediated MTOC Polarization
    • 5 F‐Actin‐Mediated Regulation of Integrins
    • 6 Cytoskeletal Dynamics and Cell Migration
    • 7 Conclusion
  • HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases
    • Abstract
    • 1 Introduction
    • 2 Expression and Function of HLA‐DQ Transgenes in Mice
    • 3 HLA‐DQ Transgenic Mice as Models for Human Allergies
    • 4 Expression and Function of HLA‐DR Transgenic Mice
    • 5 HLA Class II Transgenic Mice Identify the Same Determinants of M. Tuberculosis‐Derived Proteins as Humans
    • 6 Collagen‐Induced Arthritis—Model for Human Rheumatoid Arthritis
    • 7 Experimental Autoimmune Encephalomyelitis: A Model for Multiple Sclerosis
    • 8 Spontaneous Models for Human Type I Diabetes
    • 9 Experimental Autoimmune Myasthenia Gravis
    • 10 HLA and Gluten Sensitivity‐Celiac Disease and Dermatitis herpetiformis
    • 11 Relapsing Polychondritis
    • 12 Spontaneous Autoimmune Myocarditis
    • 13 Experimental Autoimmune Thyroiditis (Adapted from Kong et al., 2007)
    • 14 Experimental Autoimmune Uveitis (Adapted fromPennesi et al., 2003)
    • 15 Bacterial Superantigens and Toxic Shock Syndrome
    • 16 Concluding Remarks
  • Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule
    • Abstract
    • 1 Introduction
    • 2 Zn Homeostasis, Zn Transporters, and Metallothioneins in Health and Disease
    • 3 Role of Zn in the Immune Response
    • 4 Role of Zn in Mast Cells
    • 5 Zn Signaling
    • 6 Conclusion and Future Prospects
    • Acknowledgements
  • The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses
    • Abstract
    • 1 Introduction
    • 2 Structure, Ligands, and Expression of the SLAM‐Family Receptors
    • 3 The SLAM‐Family Gene Isoforms and Polymorphisms and their Role in a Genetic Predisposition for Systemic Lupus Erythematosus
    • 4 The SLAM‐Associated Protein
    • 5 The Protective Role of SAP in X‐Linked Lympho‐Proliferative Disease
    • 6 The SAP‐Related Single SH2‐Domain Proteins EAT‐2A and EAT‐2B
    • 7 The SLAM‐Family Receptors in NK Cell Responses
    • 8 The Role of the SLAM‐Family in Lymphoid Cells
    • 9 The Role of the SLAM‐Family on Nonlymphoid Cells
    • 10 Concluding Remarks
  • Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lymphocytes
    • Abstract
    • 1 Introduction
    • 2 A Minimal Signaling Kit Couples to Proximal Transducer Enzymes
    • 3 Signal Initiation: BCR Clusters with an Open Conformation
    • 4 SLP-65: A Gateway to Intracellular Signaling Pathways
    • 5 Dynamic Regulation of the BCR-Triggered Ca2+ Response
    • 6 Mechanism and Function of BCR-Induced Ras Activation
    • 7 Concluding Remarks
  • Subject Index
    • Publisher Summary
  • Contents of Recent volumes

Readership

Immunologists and infectious disease specialists, cell biologists and hematologists


Details

No. of pages:
312
Language:
English
Copyright:
© Academic Press 2008
Published:
Imprint:
Academic Press
eBook ISBN:
9780080879017
Hardcover ISBN:
9780123743244

About the Editors

Frederick Alt Editor

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA