Volume 76. Advances in Genetics

Series Page

Contributors

Sensory Functions for Degenerin/Epithelial Sodium Channels (DEG/ENaC)

I. Introduction

II. Chemosensation

III. Mechanosensation

IV. Peripheral Pain

V. Conclusions

Genetic and Phenotypic Consequences of Introgression Between Humans and Neanderthals

I. Introduction

II. The First Genetic Evidence for Introgression in Our Species

III. Evidence for Introgression Obtained from Present-Day Human Genomes

IV. History of Hominans in Europe

V. Comparison of Middle European Neanderthal Nuclear DNA with Modern Human Nuclear DNA

VI. The ABBA–BABA Test for Introgression

VII. Different Regions of the Neanderthal Genome are Found in Different Modern Humans

VIII. The Genetic Contribution of the Denisovans to Our Species

IX. Possible Range of Phenotypic Impacts of Neanderthal and Denisovan Introgressions into Modern Humans

Acknowledgments

Genomic Approaches to Understanding Hox Gene Function

I. Introduction: Historical Perspective

II. The Molecular Genetics of Hox Complexes: Conservation and Colinearity

III. Hox Target Genes and Functions

IV. Early Experiments to Identify Hox Target Genes

V. Genomic Approaches to Identifying Hox Target Genes

VI. Microarray Expression Profiling

VII. ChIP Approaches

VIII. Computational Approaches

IX. Prospects

GATA Transcription Factors in the Developing Reproductive System

I. Introduction

II. Molecular Control of Gonadal Development

III. Canonical WNT Signaling Control of Gonadal Development

IV. The GATA–FOG Transcriptional Partnership

V. GATA4–FOG2 Control of Gonadal Development

VI. Conclusions

Acknowledgment