Advances in Genetics

Advances in Genetics

1st Edition - October 9, 2014

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  • Editors: Theodore Friedmann, Jay Dunlap, Stephen Goodwin
  • eBook ISBN: 9780128003695
  • Hardcover ISBN: 9780128001493

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Description

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Volume 87 presents an eclectic mix of articles of use to all human and molecular geneticists on topics including: gene transfer, fruiting body development and the genetics of Alzheimer’s disease; and more.

Key Features

  • Includes methods for testing with ethical, legal, and social implications
  • Critically analyzes future directions
  • Written and edited by recognized leaders in the field

Readership

Molecular geneticists, clinical geneticists, neurologists, neuroscientists, molecular biologists, and biochemists.

Table of Contents

    • Advances in Genetics, Volume 87
    • Chapter One. Opportunity for Selection in Human Health
      • 1. Introduction
      • 2. Genetic Variation and Demographic Selection
      • 3. Episodes of Selection
      • 4. Selection Spectra
      • 5. Place of Multilevel Selection in Medical Practice and Public Health
      • 6. Discussion
    • Chapter Two. Clinical Applications Involving CNS Gene Transfer
      • 1. Introduction
      • 2. CNS Clinical Trials Utilizing Retroviral Vectors
      • 3. CNS Clinical Trials Utilizing AAV Vectors
      • 4. Lessons Learned from Related Studies
      • 5. Conclusion
    • Chapter Three. Methods for Gene Transfer to the Central Nervous System
      • 1. Introduction
      • 2. Vectors for CNS Gene Transfer
      • 3. Genome Designs for Optimal Expressions
      • 4. Conclusions
    • Chapter Four. The Filamentous Fungus Sordaria macrospora as a Genetic Model to Study Fruiting Body Development
      • 1. Introduction
      • 2. Genetic and Genomic Tools
      • 3. The Striatin-Interacting Phosphatase and Kinase Complex, a Multisubunit Protein Complex Governing Fruiting Body Development
      • 4. Chromatin-Related Processes
      • 5. Metabolism-Related Developmental Processes
      • 6. Autophagy
      • 7. Concluding Remarks and Outlook
    • Chapter Five. Genetics of Alzheimer’s Disease
      • 1. Introduction
      • 2. Heritability of Alzheimer’s Disease
      • 3. Genetic Causes of Early-Onset Alzheimer’s Disease
      • 4. Genetic Risk Factors for Late-Onset Alzheimer’s Disease
      • 5. Discussion
    • Index

Product details

  • No. of pages: 312
  • Language: English
  • Copyright: © Academic Press 2014
  • Published: October 9, 2014
  • Imprint: Academic Press
  • eBook ISBN: 9780128003695
  • Hardcover ISBN: 9780128001493

About the Serial Volume Editors

Theodore Friedmann

School of Medicine, University of California at San Diego, USA

Affiliations and Expertise

School of Medicine, University of California at San Diego, USA

Jay Dunlap

Dr. Jay Dunlap works at the Geisel School of Medicine at Dartmouth.

Affiliations and Expertise

The Geisel School of Medicine, Dartmouth, NH, USA

Stephen Goodwin

Dr. Stephen Goodwin works at the University of Oxford.

Affiliations and Expertise

University of Oxford, UK

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