Volume 45 of Advances in Enzyme Regulation is the proceedings of the 45th International Synthesis in Normal and Neoplastic Tissues held at Indiana University School of Medicine Indianapolis, Indiana September 27-28, 2004. Volume 45 concentrates on subjects which have reached the stage of productive summarizaiton and critical evaluation in the light of extensive new results. This book also lives up to its goal of advancing a few steps ahead of the general front of mammalian enzymic and metabolic regulation studies.

Key Features

*Latest information about mammalian enzymic and metabolic regulation studies *Comprehensive lab resource and teaching companion *International contributors from academia and industry


Biochemists, biophysicists, cell biologists, molecular biologists, geneticists, developmental biologists

Table of Contents

Acknowledgments List of participants SESSION I NUCLEAR CONTROL Implications for Nuclear Organization and Gene Transcription of Lamin A/C Specific Mutations. Spatio-Temporal Dynamics of Genomic Organization and Function in the Mammalian Cell Nucleus SESSION II METABOLIC DESIGN AND REGULATION Metabolic Design Principles: Chemical and Physical Determinants of Cell Chemistry. Down-regulation of Increased Signal Transduction in Human Cancer Cells. SESSION III RAS AND REGULATION Ras Initiates Phosphatidyl-Inositol-3-Kinase(P13K)/PKB Mediated Signalling Pathways in Untransformed Human Peripheral Blood T Lymphocytes. Functional Analysis and Secondary Espression Profiling of Candidate Genes Deregulated in Conjunction with Oncogenic Ras Signaling SESSION IV CONTROLS AND APOPTOSIS Induction of Apoptosis in p53-Deficient L1210 Cells by an I KAPPA Beta Alpha Inhibitor (Bay 11-7085) via a NF KAPPA-Beta-Independent Mechanism. Regulation of Gene and Protein Expression in Cardiac Myocyte Hypertrophy and Apoptosis. SESSION V REGULATION OF KEY ENZYMES Peptide Inhibitors of Mammalian Ribonucleotide Reductase. SESSION VI NUCLEAR FUNCTION AND HUMAN NEOPLASIA Nuclear Phospholipase C Beta1, Regulation of the Cell Cycle and Progression of Acute Myeloid Leukemia. Combinatorial Organization of the Transcriptional Regulatory Machinery in Biological Control and Cancer. SESSION VII EVOLUTIONARY CONSERVED SIGNAL PATHWAYS Phosphatidylinositol Transfer Protein Function in the Yeast Saccharomyces cerevisiae. Modification of Protein Sub-Nuclear Location by Synthetic Phosphoinositides: Evidence for Nuclear Phosphoinositide Sign


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Elsevier Science
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About the editor

George Weber

Affiliations and Expertise

Indiana University School of Medicine, Indianapolis, USA