This volume contains papers of 23 outstanding scientists who are working at the leading edge of metabolic regulation studies. Much of the volume focuses on novel aspects of signal transduction with emphasis on the role of phospholipase C in cell control mechanisms.

One of the highlights of this volume is always the Special Symposium Lecture. This lecture was given for fifteen years by Nobel laureate, Sir Hans A. Krebs (UK) (now deceased). This year the Lecture was given by Nadir Maraldi, Director of the Laboratory of Cellular Biology and Electron Microscopy, University of Bologna, Italy. Professor Maraldi's presentation is on the important and novel subject of "Nuclear Proteins and Human Disease."

Table of Contents

Acknowledgements. List of Participants. Session I. Inositide Signaling: J.G. Cory. Re-examination of the significance of nuclear localization of PLC&bgr;1 in the likelihood of its involvement in neoplastic cell growth (L. Cocco, L. Manzoli et al.). The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases (K. Backers, D. Blero, et al.). Session II. Drug targeting and resistance: L. Cocco. Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression: Convergence at Caspase-3 activation (A.H. Cory, C.C. Edwards et al.). Targeting signal transduction (G. Weber, F. Shen et al.). Session III. Tumor Metabolism: J.J. Starling. Utilization of the promoter region of the midkine gene as a tool to drive therapeutic genes in a tumor specific manner (S. Sakiyama, L. Yu et al.). Opportunities for studying cancer by metabolomics: Preliminary observations on tumors deficient in hypoxia-inducible factor 1 (J.R. Griffiths, M. Stubbs). Session IV. Control of Phospholipase: O. Greengard. Structural and mechanistic aspects of phosphoinositide C&ggr; regulation (M. Katan, R. Rodriguez et al.). Phospholipase C&dgr;: From genome structure to physiological function (K. Fukami, T. Inoue et al.). Activation of PI(4)P 5-kinase by small G proteins (Y. Kanaho, H. Miyazaki, M. Yamazaki). Session V. Oxidative Stress: N. Katunuma. Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis (P. Talalay, A.T. Dinkova-Kostova, W.D. Holtzclaw). Ferritin regulation by oxidants and chemopreventive xenobiotics (J. Wilkinson, E.C. Pietsch IV et al.). Session VI. Regulation of gene expression: J.R. Griffiths. The regulation of adipocyte metab


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Elsevier Science
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About the editor

George Weber

Affiliations and Expertise

Indiana University School of Medicine, Indianapolis, USA