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Advances in Drug Research - 1st Edition - ISBN: 9780120133222, 9781483266893

Advances in Drug Research, Volume 22

1st Edition

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Editor: Bernard Testa
eBook ISBN: 9781483266893
Imprint: Academic Press
Published Date: 28th January 1992
Page Count: 216
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Table of Contents


Preface: "All Mimsy Were the Borogoves"

Atom Description in QSAR Models: Development and Use of an Atom Level Index

1 Introduction

2 An Atom Level Description of Structure

3 Formulation of an Atom-Centered Index

4 Information from Electrotopological State Values

5 QSAR Strategy

6 Applications to Drug QSAR Problems

7 Discussion


Pharmacokinetics of Peptides and Proteins: Opportunities and Challenges

1 Introduction

2 Physicochemical Factors and Passive Distribution

3 Clearance

4 Transport of Peptides Across Mucosal Surfaces

5 Conclusions


Towards Genomic Pharmacology: From Membranal to Nuclear Receptors

1 Introduction

2 Regulation of Gene Expression

3 Nuclear Receptors

4 Induced Changes in Gene Expression

5 The Nucleus as a Target for Drug Action

6 Signal Pathways: From Membrane to Nuclear Receptors

7 Future Prospects


Medicinal Chemistry of Steroids: Recent Developments

1 Introduction

2 Steroid Receptors

3 Steroid-Converting Enzymes: The Case of 3-Oxo-Δ5-Steroid Isomerase

4 Inhibitors of Steroid-Converting Enzymes

5 Oestrogen Receptor-Based Imaging Agents

6 Conclusions and Future Developments


Subject Index

Cumulative Index of Authors

Cumulative Index of Titles


Advances in Drug Research, Volume 22 focuses on the concepts and facts of drug research. This book is divided into four chapters. Chapter 1 discusses the use of atomic properties and atom-centered indices in QSAR models, while Chapter 2 describes the pharmacokinetics of peptides and proteins. The nuclear receptors, emphasizing the aspects of molecular and genomic pharmacology are elaborated in Chapter 3. The last chapter covers the medicinal chemistry of a vast group of agents acting on nuclear receptors. This publication is valuable to drug researchers and students interested in advances in drugs.


No. of pages:
© Academic Press 1992
28th January 1992
Academic Press
eBook ISBN:

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About the Editor

Bernard Testa

Affiliations and Expertise

University Hospital Centre, Lausanne, Switzerland