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Preface: "All Mimsy Were the Borogoves"
Atom Description in QSAR Models: Development and Use of an Atom Level Index
2 An Atom Level Description of Structure
3 Formulation of an Atom-Centered Index
4 Information from Electrotopological State Values
5 QSAR Strategy
6 Applications to Drug QSAR Problems
Pharmacokinetics of Peptides and Proteins: Opportunities and Challenges
2 Physicochemical Factors and Passive Distribution
4 Transport of Peptides Across Mucosal Surfaces
Towards Genomic Pharmacology: From Membranal to Nuclear Receptors
2 Regulation of Gene Expression
3 Nuclear Receptors
4 Induced Changes in Gene Expression
5 The Nucleus as a Target for Drug Action
6 Signal Pathways: From Membrane to Nuclear Receptors
7 Future Prospects
Medicinal Chemistry of Steroids: Recent Developments
2 Steroid Receptors
3 Steroid-Converting Enzymes: The Case of 3-Oxo-Δ5-Steroid Isomerase
4 Inhibitors of Steroid-Converting Enzymes
5 Oestrogen Receptor-Based Imaging Agents
6 Conclusions and Future Developments
Cumulative Index of Authors
Cumulative Index of Titles
Advances in Drug Research, Volume 22 focuses on the concepts and facts of drug research. This book is divided into four chapters. Chapter 1 discusses the use of atomic properties and atom-centered indices in QSAR models, while Chapter 2 describes the pharmacokinetics of peptides and proteins. The nuclear receptors, emphasizing the aspects of molecular and genomic pharmacology are elaborated in Chapter 3. The last chapter covers the medicinal chemistry of a vast group of agents acting on nuclear receptors. This publication is valuable to drug researchers and students interested in advances in drugs.
- No. of pages:
- © Academic Press 1992
- 28th January 1992
- Academic Press
- eBook ISBN:
University Hospital Centre, Lausanne, Switzerland
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