Advances in Drug Research - 1st Edition - ISBN: 9780120133222, 9781483266893

Advances in Drug Research, Volume 22

1st Edition

Editors: Bernard Testa
eBook ISBN: 9781483266893
Imprint: Academic Press
Published Date: 28th January 1992
Page Count: 216
Tax/VAT will be calculated at check-out Price includes VAT (GST)
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
54.95
38.47
38.47
38.47
38.47
38.47
43.96
43.96
72.95
51.06
51.06
51.06
51.06
51.06
58.36
58.36
43.99
30.79
30.79
30.79
30.79
30.79
35.19
35.19
Unavailable
Price includes VAT (GST)
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents


Contributors

Preface: "All Mimsy Were the Borogoves"

Atom Description in QSAR Models: Development and Use of an Atom Level Index

1 Introduction

2 An Atom Level Description of Structure

3 Formulation of an Atom-Centered Index

4 Information from Electrotopological State Values

5 QSAR Strategy

6 Applications to Drug QSAR Problems

7 Discussion

References

Pharmacokinetics of Peptides and Proteins: Opportunities and Challenges

1 Introduction

2 Physicochemical Factors and Passive Distribution

3 Clearance

4 Transport of Peptides Across Mucosal Surfaces

5 Conclusions

References

Towards Genomic Pharmacology: From Membranal to Nuclear Receptors

1 Introduction

2 Regulation of Gene Expression

3 Nuclear Receptors

4 Induced Changes in Gene Expression

5 The Nucleus as a Target for Drug Action

6 Signal Pathways: From Membrane to Nuclear Receptors

7 Future Prospects

References

Medicinal Chemistry of Steroids: Recent Developments

1 Introduction

2 Steroid Receptors

3 Steroid-Converting Enzymes: The Case of 3-Oxo-Δ5-Steroid Isomerase

4 Inhibitors of Steroid-Converting Enzymes

5 Oestrogen Receptor-Based Imaging Agents

6 Conclusions and Future Developments

References

Subject Index

Cumulative Index of Authors

Cumulative Index of Titles



Description

Advances in Drug Research, Volume 22 focuses on the concepts and facts of drug research. This book is divided into four chapters. Chapter 1 discusses the use of atomic properties and atom-centered indices in QSAR models, while Chapter 2 describes the pharmacokinetics of peptides and proteins. The nuclear receptors, emphasizing the aspects of molecular and genomic pharmacology are elaborated in Chapter 3. The last chapter covers the medicinal chemistry of a vast group of agents acting on nuclear receptors. This publication is valuable to drug researchers and students interested in advances in drugs.


Details

No. of pages:
216
Language:
English
Copyright:
© Academic Press 1992
Published:
Imprint:
Academic Press
eBook ISBN:
9781483266893

About the Editors

Bernard Testa Editor

Affiliations and Expertise

University Hospital Centre, Lausanne, Switzerland