Advances in Drug Research

Contributors

Preface: Poking the Fire

Drug Targeting Towards the Lymphatics


1 Introduction


2 The Lymphatic System and Lymphatic Circulation


3 Lymphotropic Carriers and the Lymph Uptake Mechanism


4 Properties of Drug-Carrier Complexes


5 Basis of Circulation in Lymphatic Transport of Molecules via Various Routes of Administration


6 Lymphatic Delivery by Gastrointestinal Drug Dosing


7 Lymphatic Delivery by Parenteral Drug Administration


8 Conclusions and Speculation

References

Recent Developments in the Field of Quinolone Antibacterial Agents


1 Introduction


2 General Aspects and Characteristics


3 Chemical Variations and Biological Activity


4 Compounds on the Market and Under Development


5 Mode of Action and Mechanisms of Resistance


6 Perspectives

References

Design and Therapeutic Potential of Peptides


1 Introduction


2 Identification of the Minimum Active Fragment


3 Increasing the Enzymic Stability of Peptides


4 Potent Agonists and Antagonists of Peptides


5 Inhibitors of the Enkephalindegrading Dipeptidyl Carboxypeptidase (Enkephalinase)


6 Inhibitors of Atrial Natriuretic Factordegrading Enzymes


7 Angiotensin-Converting Enzyme Inhibitors


8 Renin Inhibitors


9 Nonpeptide Antagonists of Angiotensin II


10 Nonpeptide Antagonists of CCK and Gastrin


11 Delivery of Therapeutic Peptides


12 Summary and Recent Developments

Acknowledgment

References

Subject Index

Cumulative Index of Authors

Cumulative Index of Titles