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Advances in Drug Research
1st Edition, Volume 20 - January 28, 1991
Editor: Bernard Testa
Language: English
eBook ISBN:9781483265438
9 7 8 - 1 - 4 8 3 2 - 6 5 4 3 - 8
Advances in Drug Research, Volume 20 focuses on the general themes of drug research and description of specific drug classes. This book is divided into four chapters. Chapter 1…Read more
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Advances in Drug Research, Volume 20 focuses on the general themes of drug research and description of specific drug classes. This book is divided into four chapters. Chapter 1 discusses the extrapolation of toxicological and pharmacological data from animals to humans. The second chapter deals with the tissue binding of drugs, considering the relative ponderal importance of tissue versus blood macromolecules. The therapeutic use of plants and consumption of medicinal plants are elaborated in Chapter 3. The last chapter covers the field of histaminergic agonists and antagonists, describing breakthroughs such as H2-receptor antagonists, non-sedating H1-receptor antagonists, and H3-receptors. This publication is valuable to drug researchers and students interested in advances in drugs.
Contributors
Preface
Extrapolation of Toxicological and Pharmacological Data from Animals to Humans
1 Overview
2 Introduction
3 The Surface Law
4 Allometric Relationships and Biological Similarity
5 Pharmacokinetics and Comparative Metabolism
6 Discussion and Conclusions
References
Tissue Binding versus Plasma Binding of Drugs: General Principles and Pharmacokinetic Consequences
1 Introduction
2 Pharmacokinetic Consequences of Plasma and Tissue Binding
3 Methods to Assess Tissue Binding of Drugs
4 Tissue Binding versus Plasma Binding of Drugs
5 Conclusion
References
Search for New Drugs of Plant Origin
1 Introduction
2 Anticancer Agents from Higher Plants
3 Antagonists of Platelet-activating Factor
4 Antimalarial Agents
5 AIDS—Antiviral Agents
6 Miscellaneous
7 Concluding Remarks
References
Histaminergic Agonists and Antagonists: Recent Developments