Advances in CRISPR/Cas and Related Technologies

Advances in CRISPR/Cas and Related Technologies

1st Edition - March 5, 2021

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  • Editor: Dipanjan Ghosh
  • Hardcover ISBN: 9780128215906
  • eBook ISBN: 9780128215913

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Advances in CRISPR/Cas and related technologies, Volume 179, the latest release in this ongoing series, deals with a wide variety of research topics related to recent advancement in the genome editing techniques. Associated chapters in this new release include Challenges for Therapeutic application of CRISPR Cas techniques, Mitochondrial DNA modification by CRISPR Cas System: Challenges and future direction, Trends in CRISPR Cas technology application in cancer, Modified CRISPR-Cas for next generation application, Application of CRISPR Cas in Synthetic Biology: Challenges and Scopes, History of CRISPR Cas system from bacterial Adaptive Immune System to research application, and more.

Key Features

  • Covers the Cas9 protein modification for reduced off-target effect
  • Includes discussions on Cas9 utilization for Metabolic Engineering
  • Provides information on the use of Cas9 for targeted delivery in therapeutic application


Genetic Engenderers, Synthetic Biologists, Medicine Practitioners

Table of Contents

  • 1. The evolution and history of gene editing technologies

    Shubhchintan Randhawa and Shatakshi Sengar

    2. CRISPR-Cas9: A fascinating journey from bacterial immune system to human gene editing

    Munshi Azad Hossain

    3. Modification of Cas9, gRNA and PAM: Key to further regulate genome editing and its applications

    Rahul Gupta, Darshana Gupta, Kazi Tawsif Ahmed, Dhritiman Dey, Rajveer Singh, Snehasikta Swarnakar, V. Ravichandiran, Syamal Roy and Dipanjan Ghosh

    4. CRISPR/dCas system as the modulator of gene expression

    Tawsif Ahmed Kazi and Swadesh Ranjan Biswas

    5. CRISPR-Cas system, antibiotic resistance and virulence in bacteria: Through a common lens

    Subhasree Roy, Sharmi Naha, Ankur Rao and Sulagna Basu

    6. Trends in CRISPR-Cas9 technology application in cancer

    Subhadip Mukhopadhyay and Sujit Kumar Bhutia

    7. Mitochondrial DNA modification by CRISPR/Cas system: Challenges and future direction

    Rajalakshmi Prakash and Anbarasu Kannan

    8. Immune responses to CRISPR-Cas protein

    Sobhan Roy

    9. CRISPR’s got some nerves: Application of CRISPR-Cas systems in neuroscience

    Deepro Bonnerjee and Sangram Bagh

Product details

  • No. of pages: 284
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: March 5, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128215906
  • eBook ISBN: 9780128215913

About the Editor

Dipanjan Ghosh

Dipanjan Ghosh
Dr. Dipanjan Ghosh has almost 19 years of research experience in the field of Molecular Biology, Cell Biology, Biochemistry, Immunology and genome editing. Presently Dr. Ghosh is working as Assistant Professor in the Department of Natural Products at National Institute of Pharmaceutical Education and Research (NIPER)-Kolkata. After getting MSc. in Biochemistry from University of Calcutta, Dr. Ghosh went to Indian Institute of Technology (IIT) Kharagpur where he did his MTech in Biotechnology and Bioprocess Engineering and then PhD in the field of Immunology, Cancer Biology Biochemistry. In his first postdoc at University of Texas Health Science Centre at Houston he worked in the field of catalytic enzyme. He then moved to UT MD Anderson Cancer Centre, Houston TX where he gained enough experience in field of genome editing using ZFN and CRISPR Cas systems. Dr. Ghosh received DST FAST TRACK YOUNG SCIENTIST GRANT from Department of Science and Technology, India. Presently he has initiated Synthetic Biology through metabolic bioengineering at his lab and acting as leading investigator of two major funded projects (one from DBT and another one from WBDBT) in the field of CRISPR Cas mediated genome editing. Dr. Ghosh has enough experience, skill, knowledge and publication in the field of genome editing.

Affiliations and Expertise

Assistant Professor, Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, India

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