Advances in Clinical Cytology

Advances in Clinical Cytology describes the ultrastructural dynamics of endometrial hyperplasia and neoplasia. This book contains 11 chapters that evaluate the meaning of endometrial aspiration in gynecological application and address the morphologic response of hyperplastic and neoplastic endometrium to exogenous progestogens.
Some of the topics covered in the book are the evaluation of the methods of cytological sampling; population screening for cervical cancer; advances in pulmonary cytology; and selection of high-risk cases of cancer development for screening and collection of specimens. Other chapters deal with the evaluation of cytology as a method of screening, as well as the cytological features of human polyomavirus-infected cells. An analysis of the functional connections between epithelial cells is provided. The concluding chapters are devoted to the morphology of the cell surface and the method for staining smears.
The book can provide useful information to doctors, cytologists, students, and researchers.

Preface

1 The Ultrastructural Dynamics of Endometrial Hyperplasia and Neoplasia

Introduction

Normal Cyclic Endometrium

Endometrial Hyperplasia

Endometrial Neoplasia

Morphologic Response of Hyperplastic And Neoplastic Endometrium to Exogenous Progestogens

Conclusion

2 The Value of Endometrial Aspiration in Gynaecological Practice

Introduction

Methods of Cytological Sampling

Interpretation of Endometrial Aspirates

Evaluation of Aspiration Techniques

Clinical Application

Conclusion

3 An Evaluation of Population Screening for Cervical Cancer

Introduction

The Screening Test

Natural History

Evaluation of Outcome

Acceptability

Economic Considerations

Conclusion

4 Recent Advances in Pulmonary Cytology: Early Detection and Localization of Occult Lung Cancer in Symptomless Males

Introduction

Selection of High-Risk Cases for Screening and Collection of Specimens

Cytological Classification of Sputum Samples

Localization of Radiographically Occult Bronchogenic Carcinoma

Management of Patients With Positive Sputum Cytology and Negative Chest X-Ray

Technique for the Examination of Resected Specimens in Cases of Occult Carcinoma

Illustrative Cases

Evaluation of Cytology as a Method of Screening

Conclusion

5 The Cytological Diagnosis of Human Polyomavirus Infection and Its Value in Clinical Practice

Introduction

The Human Polyomaviruses BK and JC

Methods Of Detection

Cytological Appearance of Human Polyomavirus-Infected Cells

Contribution of Cytology to the Knowledge of Infection with the Human Polyomaviruses

Prospects for Research

Conclusion

6 Cell Relationships in Epithelia

Introduction

Morphology of the Cell Surface

Functional Relationships Between Epithelial Cells

Pathological Cell Relationships

Conclusion

7 Aspiration Biopsy Cytology in Diseases of the Thyroid

Introduction

Methodology

Comparison of Fine-Needle Aspiration with Other Methods of Needle Biopsy

Cytological Diagnosis of Non-Neoplastic Thyroid Disorders

Thyroid Neoplasms

Evaluation of the Cytological Method

Conclusion

8 Cytology of Ophthalmological Diseases

Introduction

Collection of Specimens

Normal Cytology

Inflammatory Diseases

Benign Ocular Lesions

Malignant Ocular Lesions

Conclusion

9 Smear Preparations in the Diagnosis of Malignant Lesions of the Central Nervous System

Introduction

Method for Staining Smears

Findings in Various Tumor Types

10 Configurations of Surfaces of Cells in Effusions by Scanning Electron Microscopy

Introduction

Technical Methods

Material

Configuration of Surfaces of Cells in Fluids

Discussion

11 Automation In Cytology: Computerized High Resolution Scanning of Cervical Smears

Introduction

Strategy of Automation

Instrumentation

Information Derived from Computed Cell Images

Cell Image Preprocessing

Cell Image Features

Cell Classification

Objective Cytodiagnosis

The Statistical Sampling Requirements for Prescreening Devices

Conclusion

Color Plate Section Facing Page

Index