Advances in Clinical Chemistry

Advances in Clinical Chemistry

1st Edition - March 10, 2022

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  • Editor: Gregory Makowski
  • Hardcover ISBN: 9780323988476
  • eBook ISBN: 9780323988483

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Description

Advances in Clinical Chemistry, Volume 107, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Advances in Quantum Dots as Diagnostic Tools, Host polymorphisms and COVID-19 infection, Biomarkers in Muscle Invasive Bladder Cancer, and more.

Key Features

  • Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science
  • Authored by world renowned clinical laboratory scientists, physicians and research scientists
  • Presents the international benchmark for novel analytical approaches in the clinical laboratory

Readership

Clinical Laboratory Professionals, Physicians and Research Scientists

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter One: Advances in quantum dots as diagnostic tools
  • Abstract
  • 1: Introduction
  • 2: Quantum dots: Synthesis, functionalization and characterization
  • 3: Quantum dots for point-of-care (POC) diagnosis
  • 4: Ultrasensitive biomarker detection based on quantum dots
  • 5: Bioconjugated quantum dots for molecular imaging
  • 6: Summary and future perspectives
  • Acknowledgments
  • References
  • Chapter Two: Host polymorphisms and COVID-19 infection
  • Abstract
  • 1: Introduction
  • 2: Genetic polymorphisms affecting the angiotensin-converting enzyme 2 expression (Table 1)
  • 3: Genetic polymorphisms affecting the immune response against COVID-19 (Table 2)
  • 4: Associated genetic polymorphisms (Table 3)
  • 5: Conclusion
  • References
  • Chapter Three: Clinical metabolomics for inborn errors of metabolism
  • Abstract
  • 1: Introduction
  • 2: Overview of metabolomics
  • 3: Overview of inborn error of metabolism laboratory diagnosis
  • 4: Analytical methodology
  • 5: Computations for reference population comparisons
  • 6: Bridging to reference populations and other analytical considerations
  • 7: Clinical utility of metabolomics for the identification of IEMs
  • 8: Future applications and challenges
  • 9: Conclusions
  • References
  • Chapter Four: Amino acids in inflammatory bowel diseases: Modern diagnostic tools and methodologies
  • Abstract
  • 1: Introduction
  • 2: Inflammatory bowel diseases
  • 3: Biomarkers of inflammatory bowel disease
  • 4: Amino acids as biomarkers and their role in inflammatory bowel disease
  • 5: Analytical strategies for analysis of amino acids in biological samples
  • 6: Current studies of amino acids in IBD
  • 7: Conclusion
  • References
  • Chapter Five: Advances in sports genomics
  • Abstract
  • 1: Introduction
  • 2: Genome-wide association (GWAS) and whole genome sequencing (WGS) studies in sport
  • 3: Gene variants for endurance athlete status
  • 4: Gene variants for power athlete status
  • 5: Gene variants for strength athlete status
  • 6: Gene variants for soft tissue injuries
  • 7: Conclusion
  • References
  • Chapter Six: Biomarkers in muscle invasive bladder cancer
  • Abstract
  • 1: Introduction
  • 2: Current treatment of MIBC
  • 3: The unmet need for robust biomarkers in MIBC
  • 4: Urinary biomarkers
  • 5: Gene expression signatures predicting lymph node metastasis
  • 6: Biomarkers of anti-tumor immunity
  • 7: Hypoxia biomarkers
  • 8: Biomarkers of DNA damage repair
  • 9: Clinical trials of poly ADP ribose polymerase (PARP) inhibitors
  • 10: Other molecular biomarkers
  • 11: Molecular taxonomy
  • 12: The fibroblast growth factor receptor (FGFR) pathway
  • 13: Liquid biopsy
  • 14: Micro-RNA
  • 15: Conclusion
  • References
  • Index

Product details

  • No. of pages: 320
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: March 10, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323988476
  • eBook ISBN: 9780323988483

About the Editor

Gregory Makowski

Gregory Makowski
Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

Affiliations and Expertise

Clinical Laboratory Partners, Newington; Hartford Hospital, Hartford; Department of Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, USA

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